Aspergillus clavatus         DUB/JAMM


※ DUB/JAMM family introduction

    Members of JAMM family are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors (1). This family is also known as the MPN domain and PAD-1-like domain JABP1 domain or JAMM domain, while the JAMM motif is critical for the activity (1-2). These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are predicted to have a similar role (3).

1. http://pfam.sanger.ac.uk/family/PF01398

2. Verma, R., Aravind, L., Oania, R., McDonald, W.H., Yates, J.R., 3rd, Koonin, E.V. and Deshaies, R.J. (2002) Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science, 298, 611-615. PMID: 12183636

3. Cope, G.A., Suh, G.S., Aravind, L., Schwarz, S.E., Zipursky, S.L., Koonin, E.V. and Deshaies, R.J. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science, 298, 608-611. PMID: 12183637




There are 4 genes.  Reviewed (0 or Unreviewed (4Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Acl-008338
CADACLAG00008317
A1CEW5
ACLA_091120
IUUC-Acl-008155
CADACLAG00006801
A1C7W2
ACLA_075210
IUUC-Acl-008365
CADACLAG00002911
A1CQH7
ACLA_026150
IUUC-Acl-008087
CADACLAG00001314
A1CA57
ACLA_010510