Macaca mulatta         DUB/JAMM


※ DUB/JAMM family introduction

    Members of JAMM family are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors (1). This family is also known as the MPN domain and PAD-1-like domain JABP1 domain or JAMM domain, while the JAMM motif is critical for the activity (1-2). These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are predicted to have a similar role (3).

1. http://pfam.sanger.ac.uk/family/PF01398

2. Verma, R., Aravind, L., Oania, R., McDonald, W.H., Yates, J.R., 3rd, Koonin, E.V. and Deshaies, R.J. (2002) Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science, 298, 611-615. PMID: 12183636

3. Cope, G.A., Suh, G.S., Aravind, L., Schwarz, S.E., Zipursky, S.L., Koonin, E.V. and Deshaies, R.J. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science, 298, 608-611. PMID: 12183637




There are 5 genes.  Reviewed (0 or Unreviewed (5Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Mcc-055385
ENSMMUG00000011800.3
F7A6Y3
MYSM1
IUUC-Mcc-054613
ENSMMUG00000015010.3
F6V6M4
EIF3F; EIF3S5; EGK_06499
IUUC-Mcc-054679
ENSMMUG00000013440.3
F6YPF9
COPS6
IUUC-Mcc-055279
ENSMMUG00000011906.3
F7HMX1
PSMD14
IUUC-Mcc-055667
ENSMMUG00000006281.3
F7H142
COPS5; EGK_19011