Xiphophorus maculatus         E1


※ E1 family introduction

    E1, also known as an ubiquitin-activating enzyme, catalyzes the first step in the ubiquitination reaction. In addition to E1s of ubiquitination, E1s also represents E1s of ubiquitin-like modification (1). At the start of the conjugation cascade, the E1 enzyme binds ATP-Mg2+ and ubiquitin or ubiquitin-like, and catalyses ubiquitin or ubiquitin-like C-terminal acyl adenylation. In the next step a catalytic cysteine on the E1 enzyme attacks the ubiquitin-AMP or ubiquitin-like-AMP complex through acyl substitution, simultaneously creating a thioester bond and an AMP leaving group. Finally, the E1~ubiquitin or E1~ubiquitin-like complex transfers ubiquitin or ubiquitin-like to an E2 enzyme, respectively. This pathway repeats itself until the target protein has a full chain of ubiquitin or ubiquitin-like attached to itself (2).

1. http://en.wikipedia.org/wiki/Ubiquitin-activating_enzyme

2. Schulman, B.A. and Harper, J.W. (2009) Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat. Rev. Mol. Cell Biol., 10, 319-331. PMID: 19352404




There are 10 genes.  Reviewed (0 or Unreviewed (10Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Xma-133930
ENSXMAG00000018987.1
M4AX66
nae1
IUUC-Xma-133015
ENSXMAG00000017429.1
M4ASN6
atg7
IUUC-Xma-133000
ENSXMAG00000016439.1
M4APV8
uba7
IUUC-Xma-133356
ENSXMAG00000016399.1
M4APQ4
UBA3 (1 of many)
IUUC-Xma-133552
ENSXMAG00000016073.1
M4ANU4
uba2
IUUC-Xma-133494
ENSXMAG00000012548.1
M4ADR7
si:dkey-82j4.2
IUUC-Xma-134209
ENSXMAG00000010468.1
M4A7S1
uba3
IUUC-Xma-133805
ENSXMAG00000008274.1
M4A1H0
uba1
IUUC-Xma-133482
ENSXMAG00000003960.1
M3ZP32
sae1
IUUC-Xma-133110
ENSXMAG00000002572.1
M3ZK46
uba5