Caenorhabditis elegans         E3 activity/RING/U-box


※ E3 activity/RING/U-box family introduction

    The U-box is a protein domain with about 70 amino acids. Although the U-box domain is similar with the RING domain, the zinc-binding sites in the RING domain are replaced by conserved charged and polar residues to maintain structure and activity (1). Previously, the U-box protein was considered as a ubiquitin chain assembly factor to catalyze the formation of a ubiquitin chain on ubiquitinated substrates, while recent studies showed that it could mediate polyubiquitylation in the absence of a HECT type or RING-finger type E3. Although the understanding of the detailed mechanisms and functions of the U-box proteins are still limited, it is proposed that they are involved in various biological processes such as the cellular stress response to the intracellular accumulation of abnormal proteins (2).

1. http://www.ebi.ac.uk/interpro/entry/IPR003613

2. Hatakeyama, S. and K. I. Nakayama (2003) U-box proteins as a new family of ubiquitin ligases. Biochem. Biophys. Res. Commun., 302(4): 635-45. PMID: 12646216




There are 10 genes.  Reviewed (2 or Unreviewed (8Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Cel-018606
WBGene00006734
Q09349
ufd-2; T05H10.5
IUUC-Cel-018356
WBGene00011365
Q03605
T02C1.1
IUUC-Cel-018336
WBGene00002175
Q9U308
jac-1; Y105C5B.21
IUUC-Cel-018271
WBGene00020423
Q10051
prp-19; T10F2.4
IUUC-Cel-018323
WBGene00000500
G5ECY6
chn-1; 1G758; CELE_T09B4.10; T09B4.10
IUUC-Cel-018637
WBGene00019898
Q21755
R05G6.4
IUUC-Cel-018328
WBGene00000880
P52012
cyn-4; cyp-4; mog-6; F59E10.2
IUUC-Cel-018370
WBGene00003917
H2L089
par-2; CELE_F58B6.3; F58B6.3
IUUC-Cel-018189
WBGene00002261
G5EEL0
ldb-1; CELE_F58A3.1; F58A3.1
IUUC-Cel-018532
WBGene00009477
O62235
rbpl-1; CELE_F36F2.3; F36F2.3