Dasypus novemcinctus         E3 activity/RING/U-box


※ E3 activity/RING/U-box family introduction

    The U-box is a protein domain with about 70 amino acids. Although the U-box domain is similar with the RING domain, the zinc-binding sites in the RING domain are replaced by conserved charged and polar residues to maintain structure and activity (1). Previously, the U-box protein was considered as a ubiquitin chain assembly factor to catalyze the formation of a ubiquitin chain on ubiquitinated substrates, while recent studies showed that it could mediate polyubiquitylation in the absence of a HECT type or RING-finger type E3. Although the understanding of the detailed mechanisms and functions of the U-box proteins are still limited, it is proposed that they are involved in various biological processes such as the cellular stress response to the intracellular accumulation of abnormal proteins (2).

1. http://www.ebi.ac.uk/interpro/entry/IPR003613

2. Hatakeyama, S. and K. I. Nakayama (2003) U-box proteins as a new family of ubiquitin ligases. Biochem. Biophys. Res. Commun., 302(4): 635-45. PMID: 12646216




There are 44 genes.  Reviewed (0 or Unreviewed (44Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Dno-029065
ENSDNOG00000031618.1
TRIM35
IUUC-Dno-029233
ENSDNOG00000036990.1
TRIM7
IUUC-Dno-029918
ENSDNOG00000032439.1
LDB1
IUUC-Dno-030032
ENSDNOG00000031700.1
Q6X873
RAG1
IUUC-Dno-029580
ENSDNOG00000046467.1
TRIM11
IUUC-Dno-030087
ENSDNOG00000034488.1
STUB1
IUUC-Dno-030085
ENSDNOG00000038672.1
RNF125
IUUC-Dno-029175
ENSDNOG00000034643.1
IUUC-Dno-029255
ENSDNOG00000036877.1
TRAF3IP2
IUUC-Dno-030061
ENSDNOG00000048992.1
TRIM21
IUUC-Dno-029511
ENSDNOG00000035444.1
IUUC-Dno-029492
ENSDNOG00000038027.1
C1FY33
TRIM6
IUUC-Dno-029430
ENSDNOG00000048802.1
RBBP6
IUUC-Dno-029501
ENSDNOG00000045723.1
NOSIP
IUUC-Dno-029378
ENSDNOG00000030998.1
IUUC-Dno-029760
ENSDNOG00000044915.1
IUUC-Dno-029134
ENSDNOG00000049234.1
UBOX5
IUUC-Dno-029518
ENSDNOG00000018405.3
LONRF3
IUUC-Dno-029361
ENSDNOG00000033322.1
TRIM68
IUUC-Dno-028912
ENSDNOG00000037509.1
IUUC-Dno-029265
ENSDNOG00000041020.1
IUUC-Dno-029481
ENSDNOG00000048132.1
IUUC-Dno-029551
ENSDNOG00000039907.1
IUUC-Dno-029197
ENSDNOG00000034498.1
IUUC-Dno-029090
ENSDNOG00000033261.1
IUUC-Dno-028862
ENSDNOG00000045638.1
TRIM61
IUUC-Dno-029210
ENSDNOG00000041949.1
RNF151
IUUC-Dno-028914
ENSDNOG00000034842.1
IUUC-Dno-029180
ENSDNOG00000025757.1
TRIM59
IUUC-Dno-029029
ENSDNOG00000024314.2
PPIL2
IUUC-Dno-028917
ENSDNOG00000024159.2
TRAF4
IUUC-Dno-029741
ENSDNOG00000024352.2
TRIM38
IUUC-Dno-029284
ENSDNOG00000018334.3
LONRF1
IUUC-Dno-029735
ENSDNOG00000014260.2
NSMCE2
IUUC-Dno-029530
ENSDNOG00000013974.3
TRIM58
IUUC-Dno-029785
ENSDNOG00000010644.2
UBE4A
IUUC-Dno-029437
ENSDNOG00000009113.2
RNF114
IUUC-Dno-029282
ENSDNOG00000008820.3
UBE4B
IUUC-Dno-028894
ENSDNOG00000008833.3
IUUC-Dno-029845
ENSDNOG00000006133.3
IUUC-Dno-029453
ENSDNOG00000005797.2
PRPF19
IUUC-Dno-028919
ENSDNOG00000005481.2
WDSUB1
IUUC-Dno-029974
ENSDNOG00000002458.3
IUUC-Dno-029337
ENSDNOG00000001170.2
TRIM17