Fusarium oxysporum         E3 activity/RING/U-box


※ E3 activity/RING/U-box family introduction

    The U-box is a protein domain with about 70 amino acids. Although the U-box domain is similar with the RING domain, the zinc-binding sites in the RING domain are replaced by conserved charged and polar residues to maintain structure and activity (1). Previously, the U-box protein was considered as a ubiquitin chain assembly factor to catalyze the formation of a ubiquitin chain on ubiquitinated substrates, while recent studies showed that it could mediate polyubiquitylation in the absence of a HECT type or RING-finger type E3. Although the understanding of the detailed mechanisms and functions of the U-box proteins are still limited, it is proposed that they are involved in various biological processes such as the cellular stress response to the intracellular accumulation of abnormal proteins (2).

1. http://www.ebi.ac.uk/interpro/entry/IPR003613

2. Hatakeyama, S. and K. I. Nakayama (2003) U-box proteins as a new family of ubiquitin ligases. Biochem. Biophys. Res. Commun., 302(4): 635-45. PMID: 12646216




There are 9 genes.  Reviewed (0 or Unreviewed (9Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Fox-037909
FOXG_11140
A0A0D2Y4D7
IUUC-Fox-037922
FOXG_10343
A0A0D2Y249
FOXG_10343
IUUC-Fox-037703
FOXG_09511
A0A0D2XZS9
FOXG_09511
IUUC-Fox-037795
FOXG_09501
A0A0D2XZR9
FOXG_09501
IUUC-Fox-037811
FOXG_09067
A0A0D2XYJ5
FOXG_09067
IUUC-Fox-037866
FOXG_08629
A0A0D2XXB3
FOXG_08629
IUUC-Fox-038028
FOXG_08397
A0A0D2XWN1
FOXG_08397
IUUC-Fox-037751
FOXG_08225
A0A0D2XW61
IUUC-Fox-037843
FOXG_03253
A0A0D2XH55
FOXG_03253