Setaria italica         E3 activity/RING/U-box


※ E3 activity/RING/U-box family introduction

    The U-box is a protein domain with about 70 amino acids. Although the U-box domain is similar with the RING domain, the zinc-binding sites in the RING domain are replaced by conserved charged and polar residues to maintain structure and activity (1). Previously, the U-box protein was considered as a ubiquitin chain assembly factor to catalyze the formation of a ubiquitin chain on ubiquitinated substrates, while recent studies showed that it could mediate polyubiquitylation in the absence of a HECT type or RING-finger type E3. Although the understanding of the detailed mechanisms and functions of the U-box proteins are still limited, it is proposed that they are involved in various biological processes such as the cellular stress response to the intracellular accumulation of abnormal proteins (2).

1. http://www.ebi.ac.uk/interpro/entry/IPR003613

2. Hatakeyama, S. and K. I. Nakayama (2003) U-box proteins as a new family of ubiquitin ligases. Biochem. Biophys. Res. Commun., 302(4): 635-45. PMID: 12646216




There are 86 genes.  Reviewed (0 or Unreviewed (86Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Sit-109939
Si039907m.g
K4ALX2
SETIT_039907mg
IUUC-Sit-110107
Si039355m.g
K4AKD2
SETIT_039355mg
IUUC-Sit-110295
Si039111m.g
K4AJP0
SETIT_039111mg
IUUC-Sit-109979
Si038719m.g
K4AIK7
SETIT_038719mg
IUUC-Sit-110200
Si035837m.g
K4AAD0
LOC101760835; SETIT_035837mg
IUUC-Sit-110620
Si035720m.g
K4AA14
LOC101783103; SETIT_035720mg
IUUC-Sit-109976
Si035714m.g
K4AA08
LOC101783635; SETIT_035714mg
IUUC-Sit-109761
Si035597m.g
K4A9P1
LOC101779597; SETIT_035597mg
IUUC-Sit-110369
Si034883m.g
K4A7M7
LOC101762703; SETIT_034883mg
IUUC-Sit-110821
Si034816m.g
K4A7G0
LOC101781744; SETIT_034816mg
IUUC-Sit-109891
Si034810m.g
K4A7F4
LOC101758114; SETIT_034810mg
IUUC-Sit-110495
Si034530m.g
K4A6M5
LOC101771736; SETIT_034530mg
IUUC-Sit-110725
Si034488m.g
K4A6I4
LOC101752569; SETIT_034488mg
IUUC-Sit-109873
Si034460m.g
K4A6F6
LOC101784568; SETIT_034460mg
IUUC-Sit-109929
Si034286m.g
K4A5Y2
LOC101758536; SETIT_034286mg
IUUC-Sit-109920
Si034147m.g
K4A5J3
LOC101767182; SETIT_034147mg
IUUC-Sit-109949
Si034048m.g
K4A594
LOC101777433; SETIT_034048mg
IUUC-Sit-109984
Si032533m.g
K4A0Z2
LOC101753760; SETIT_032533mg
IUUC-Sit-109928
Si031175m.g
K3ZX43
LOC101765482; SETIT_031175mg
IUUC-Sit-110079
Si029391m.g
K3ZS11
LOC101780058; SETIT_029391mg
IUUC-Sit-110113
Si029090m.g
K3ZR60
LOC101772081; SETIT_029090mg
IUUC-Sit-110219
Si029006m.g
K3ZQX6
LOC101768608; SETIT_029006mg
IUUC-Sit-109770
Si028933m.g
K3ZQQ3
LOC101760243; SETIT_028933mg
IUUC-Sit-109712
Si028897m.g
K3ZQL7
LOC101767654; SETIT_028897mg
IUUC-Sit-110366
Si024634m.g
K3ZDJ6
LOC101773335; SETIT_024634mg
IUUC-Sit-110788
Si024545m.g
K3ZDB1
LOC101777679; SETIT_024545mg
IUUC-Sit-109934
Si023017m.g
K3Z8Z7
LOC101782523; SETIT_023017mg
IUUC-Sit-110665
Si022917m.g
K3Z8P7
LOC101762127; SETIT_022917mg
IUUC-Sit-110571
Si022170m.g
K3Z6K1
LOC101772242; SETIT_022170mg
IUUC-Sit-110215
Si022018m.g
K3Z650
LOC101754698; SETIT_022018mg
IUUC-Sit-109763
Si021905m.g
K3Z5T7
LOC101758491; SETIT_021905mg
IUUC-Sit-110715
Si021655m.g
K3Z537
LOC101757151; SETIT_021655mg
IUUC-Sit-110392
Si021390m.g
K3Z4C2
LOC101777005; SETIT_021390mg
IUUC-Sit-110588
Si021319m.g
K3Z451
LOC101777010; SETIT_021319mg
IUUC-Sit-110490
Si021242m.g
K3Z3X4
LOC101754052; SETIT_021242mg
IUUC-Sit-109870
Si020151m.g
K3Z0T4
LOC101781790; SETIT_020151mg
IUUC-Sit-109753
Si019301m.g
K3YYF1
LOC101759787; SETIT_019301mg
IUUC-Sit-110186
Si017372m.g
K3YSX7
LOC101770991; SETIT_017372mg
IUUC-Sit-110734
Si017274m.g
K3YSM9
LOC101760042; SETIT_017274mg
IUUC-Sit-110134
Si017223m.g
K3YSH9
LOC101762740; SETIT_017223mg
IUUC-Sit-109812
Si017172m.g
K3YSC8
LOC101778838; SETIT_017172mg
IUUC-Sit-110812
Si017157m.g
K3YSB3
LOC101784755; SETIT_017157mg
IUUC-Sit-110832
Si017060m.g
K3YS16
SETIT_017060mg
IUUC-Sit-110422
Si016624m.g
K3YQT0
LOC101765060; SETIT_016624mg
IUUC-Sit-110213
Si016587m.g
K3YQP3
LOC101756006; SETIT_016587mg
IUUC-Sit-110248
Si016507m.g
K3YQG4
LOC101754779; SETIT_016507mg
IUUC-Sit-110432
Si016484m.g
K3YQE1
LOC101755867; SETIT_016484mg
IUUC-Sit-110022
Si016453m.g
K3YQB0
LOC101763692; SETIT_016453mg
IUUC-Sit-110451
Si016441m.g
K3YQ99
LOC101761389; SETIT_016441mg
IUUC-Sit-110197
Si016314m.g
K3YPX2
LOC101766002; SETIT_016314mg
IUUC-Sit-110413
Si016305m.g
K3YPW3
LOC101767639; SETIT_016305mg
IUUC-Sit-110498
Si016226m.g
K3YPN4
LOC101780036; SETIT_016226mg
IUUC-Sit-110482
Si016212m.g
K3YPM0
SETIT_016212mg
IUUC-Sit-110463
Si015737m.g
K3YN97
LOC101757093; SETIT_015737mg
IUUC-Sit-110072
Si014243m.g
K3YJ24
LOC101760049; SETIT_014243mg
IUUC-Sit-110168
Si013997m.g
K3YIC8
LOC101766684; SETIT_013997mg
IUUC-Sit-110542
Si013440m.g
K3YGS2
LOC101778843; SETIT_013440mg
IUUC-Sit-110127
Si013335m.g
K3YGG7
LOC101767769; SETIT_013335mg
IUUC-Sit-110349
Si013258m.g
K3YG90
LOC101769516; SETIT_013258mg
IUUC-Sit-110030
Si012788m.g
K3YEX1
LOC101784926; SETIT_012788mg
IUUC-Sit-110187
Si012592m.g
A0A0Q3V174
SETIT_012592mg
IUUC-Sit-110255
Si012408m.g
K3YDV0
LOC101774532; SETIT_012408mg
IUUC-Sit-110225
Si012332m.g
A0A0Q3SGT3
SETIT_012332mg
IUUC-Sit-109991
Si012240m.g
K3YDD5
LOC101779410; SETIT_012240mg
IUUC-Sit-110010
Si011652m.g
K3YBQ8
SETIT_011652mg
IUUC-Sit-110543
Si010872m.g
K3Y9I1
LOC101754403; SETIT_010872mg
IUUC-Sit-110629
Si010229m.g
K3Y7N8
LOC101784922; SETIT_010229mg
IUUC-Sit-110583
Si010124m.g
K3Y7D3
LOC101779413; SETIT_010124mg
IUUC-Sit-109759
Si009444m.g
K3Y5F6
SETIT_009444mg
IUUC-Sit-110478
Si009362m.g
K3Y574
LOC101775607; SETIT_009362mg
IUUC-Sit-110533
Si008014m.g
K3Y1E9
LOC101754209; SETIT_008014mg
IUUC-Sit-109975
Si006416m.g
K3XWV8
LOC101765542; SETIT_006416mg
IUUC-Sit-109782
Si006345m.g
K3XWN7
LOC101786578; SETIT_006345mg
IUUC-Sit-110461
Si006159m.g
K3XW51
SETIT_006159mg
IUUC-Sit-109692
Si005963m.g
K3XVK5
LOC101770419; SETIT_005963mg
IUUC-Sit-110444
Si005916m.g
K3XVF9
SETIT_005916mg
IUUC-Sit-110182
Si005898m.g
K3XVE1
LOC101764596; SETIT_005898mg
IUUC-Sit-109809
Si005894m.g
K3XVD7
LOC101754189; SETIT_005894mg
IUUC-Sit-110427
Si005883m.g
K3XVC6
LOC101784022; SETIT_005883mg
IUUC-Sit-110322
Si005763m.g
K3XV06
LOC101771084; SETIT_005763mg
IUUC-Sit-110376
Si002682m.g
K3XLA9
LOC101755974; SETIT_002682mg
IUUC-Sit-110520
Si001665m.g
K3XIE3
LOC101786872; SETIT_001665mg
IUUC-Sit-110652
Si000518m.g
K3XF51
LOC101775303; SETIT_000518mg
IUUC-Sit-109865
Si000355m.g
K3XEN8
LOC101779505; SETIT_000355mg
IUUC-Sit-110210
Si000346m.g
K3XEM9
LOC101767481; SETIT_000346mg
IUUC-Sit-110152
Si000162m.g
K3XE45
LOC101752728; SETIT_000162mg