CDC20 represents a family of substrate-specific activators of APC-dependent ubiquitination, which can promote the degradation of the APC substrate (1). Members of CDC20 family share the C-terminal WD40 domain that recognize and bind substrate (2). In human, there are two members, CDC20 and FZR1, while in yeast there exist three, CDC20, CDH1 and AMA1.

1. Visintin, R., Prinz, S. and Amon, A. (1997). CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science, 278, 460-463. PMID: 9334304

2. Kimata, Y., Baxter, J.E., Fry, A.M. and Yamano, H. (2008). A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment. Mol. Cell, 32, 576-583. PMID: 19026787