Ailuropoda melanoleuca         E3 adaptor/Cullin RING/BCR/BTB_3-box


※ E3 adaptor/Cullin RING/BCR/BTB_3-box family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_3-box family as the proteins contain both BTB domain and 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID: 16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 34 genes.  Reviewed (0 or Unreviewed (34Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Aml-002373
ENSAMEG00000020221.1
D2HIK3
KLHL25; PANDA_011043
IUUC-Aml-001434
ENSAMEG00000019026.1
D2H679
ENC1; PANDA_005457
IUUC-Aml-002412
ENSAMEG00000018934.1
G1MKV0
KBTBD7
IUUC-Aml-001587
ENSAMEG00000018925.1
D2H2S2
KBTBD6; PANDA_003946
IUUC-Aml-001509
ENSAMEG00000017418.1
D2H2B7
KLHL6; PANDA_003765
IUUC-Aml-001447
ENSAMEG00000017409.1
G1MGB7
KLHL24
IUUC-Aml-002095
ENSAMEG00000016546.1
G1MDQ5
KLHL17
IUUC-Aml-001632
ENSAMEG00000016293.1
G1MCZ5
KLHL3
IUUC-Aml-001974
ENSAMEG00000015598.1
G1MAT4
KLHL20
IUUC-Aml-002164
ENSAMEG00000014009.1
D2H7J5
GAN; PANDA_006123
IUUC-Aml-001672
ENSAMEG00000013728.1
D2HC45
IPP; PANDA_008137
IUUC-Aml-001536
ENSAMEG00000012830.1
G1M2K8
KLHL18
IUUC-Aml-001792
ENSAMEG00000012471.1
G1M1B9
KLHL40
IUUC-Aml-002307
ENSAMEG00000012318.1
G1M0X8
SPOP
IUUC-Aml-002301
ENSAMEG00000012152.1
G1M0H4
KLHL12
IUUC-Aml-002285
ENSAMEG00000011549.1
G1LYI2
KLHL42
IUUC-Aml-001377
ENSAMEG00000011445.1
G1LY84
KEAP1
IUUC-Aml-002097
ENSAMEG00000011165.1
D2HEW7
KLHL22; PANDA_009375
IUUC-Aml-002167
ENSAMEG00000010622.1
G1LVT1
KLHL41
IUUC-Aml-001639
ENSAMEG00000010557.1
G1LVJ3
KLHL23
IUUC-Aml-001782
ENSAMEG00000009634.1
G1LST4
KLHL21
IUUC-Aml-001980
ENSAMEG00000006674.1
D2HI38
KBTBD2; PANDA_010824
IUUC-Aml-002239
ENSAMEG00000005803.1
G1LGS5
KLHL11
IUUC-Aml-001576
ENSAMEG00000005782.1
D2HIS0
KLHL10; PANDA_011139
IUUC-Aml-002378
ENSAMEG00000005550.1
G1LG58
KLHL2
IUUC-Aml-001478
ENSAMEG00000005121.1
G1LET7
KLHL1
IUUC-Aml-001422
ENSAMEG00000004825.1
D2HZX0
KLHL4; PANDA_018390
IUUC-Aml-001449
ENSAMEG00000003441.1
G1L9P2
RCBTB1
IUUC-Aml-001981
ENSAMEG00000003365.1
D2HGT4
KLHL7; PANDA_010264
IUUC-Aml-001239
ENSAMEG00000003311.1
G1L9F5
KLHL5
IUUC-Aml-001443
ENSAMEG00000003314.1
D2GX65
KLHL8; PANDA_001455
IUUC-Aml-001309
ENSAMEG00000002595.1
D2HPC9
SPOPL; PANDA_013623
IUUC-Aml-001581
ENSAMEG00000002211.1
G1L601
KLHL28
IUUC-Aml-001184
ENSAMEG00000001782.1
D2H3B5
KLHL13; PANDA_004171