Ochotona princeps         E3 adaptor/Cullin RING/BCR/BTB_3-box


※ E3 adaptor/Cullin RING/BCR/BTB_3-box family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_3-box family as the proteins contain both BTB domain and 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID: 16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 29 genes.  Reviewed (0 or Unreviewed (29Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Opr-070599
ENSOPRG00000017162.1
KLHL8
IUUC-Opr-071121
ENSOPRG00000016833.1
KLHL29
IUUC-Opr-070269
ENSOPRG00000013937.1
KLHL7
IUUC-Opr-070287
ENSOPRG00000013389.1
KLHL3
IUUC-Opr-070403
ENSOPRG00000013132.1
KLHL1
IUUC-Opr-070696
ENSOPRG00000012297.1
RCBTB1
IUUC-Opr-070658
ENSOPRG00000012186.1
KLHL21
IUUC-Opr-070942
ENSOPRG00000011062.2
IUUC-Opr-071143
ENSOPRG00000010201.1
KLHL12
IUUC-Opr-070823
ENSOPRG00000009973.1
KLHL23
IUUC-Opr-070762
ENSOPRG00000008022.1
KLHL11
IUUC-Opr-071203
ENSOPRG00000008014.1
KLHL10
IUUC-Opr-070332
ENSOPRG00000007930.1
KLHL42
IUUC-Opr-071059
ENSOPRG00000007629.1
KLHL22
IUUC-Opr-070432
ENSOPRG00000007559.1
KEAP1
IUUC-Opr-070367
ENSOPRG00000006305.1
KLHL17
IUUC-Opr-070825
ENSOPRG00000006155.1
KLHL9
IUUC-Opr-070569
ENSOPRG00000005987.2
BTBD9
IUUC-Opr-070638
ENSOPRG00000005921.2
KLHL6
IUUC-Opr-070703
ENSOPRG00000005389.1
KLHL41
IUUC-Opr-070368
ENSOPRG00000005372.1
KLHL24
IUUC-Opr-071109
ENSOPRG00000005142.1
IUUC-Opr-070941
ENSOPRG00000003458.1
GAN
IUUC-Opr-070281
ENSOPRG00000003176.1
SPOPL
IUUC-Opr-070814
ENSOPRG00000003011.1
KLHL5
IUUC-Opr-070899
ENSOPRG00000002499.1
KBTBD2
IUUC-Opr-070238
ENSOPRG00000001818.1
ENC1
IUUC-Opr-070490
ENSOPRG00000000886.1
SPOP
IUUC-Opr-070240
ENSOPRG00000000098.1
KLHL38