Oryza meridionalis         E3 adaptor/Cullin RING/BCR/BTB_3-box


※ E3 adaptor/Cullin RING/BCR/BTB_3-box family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_3-box family as the proteins contain both BTB domain and 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID: 16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 17 genes.  Reviewed (0 or Unreviewed (17Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Ome-081317
OMERI11G16940
A0A0E0F7V5
IUUC-Ome-081220
OMERI10G08030
A0A0E0EY49
IUUC-Ome-081364
OMERI10G07950
A0A0E0EY43
IUUC-Ome-081429
OMERI10G07930
A0A0E0EY41
IUUC-Ome-081182
OMERI08G15210
A0A0E0EMR3
IUUC-Ome-081628
OMERI08G06570
A0A0E0EJB5
IUUC-Ome-081118
OMERI08G06460
A0A0E0EJA5
IUUC-Ome-081523
OMERI08G06400
A0A0E0EJ99
IUUC-Ome-081102
OMERI08G01910
A0A0E0EHF4
IUUC-Ome-081542
OMERI08G01900
A0A0E0EHF3
IUUC-Ome-081620
OMERI06G24460
A0A0E0E562
IUUC-Ome-081547
OMERI06G24450
A0A0E0E561
IUUC-Ome-081374
OMERI06G11080
A0A0E0DZX0
IUUC-Ome-081486
OMERI05G20840
A0A0E0DU18
IUUC-Ome-081729
OMERI04G23990
A0A0E0DJM1
IUUC-Ome-081936
OMERI04G21600
A0A0E0DIM7
IUUC-Ome-081883
OMERI02G01730
A0A0E0CED5