Amborella trichopoda         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 25 genes.  Reviewed (0 or Unreviewed (25Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Atr-002929
AMTR_s00055p00188830
U5CYB0
AMTR_s00055p00188830
IUUC-Atr-003072
AMTR_s00055p00188480
U5DD40
AMTR_s00055p00188480
IUUC-Atr-002638
AMTR_s00036p00114630
U5CQ74
AMTR_s00036p00114630
IUUC-Atr-003091
AMTR_s00032p00112510
U5CXX0
AMTR_s00032p00112510
IUUC-Atr-002568
AMTR_s00025p00244620
W1PYT5
AMTR_s00025p00244620
IUUC-Atr-002922
AMTR_s00025p00114450
W1PWV4
AMTR_s00025p00114450
IUUC-Atr-002763
AMTR_s00164p00032900
W1PS87
AMTR_s00164p00032900
IUUC-Atr-002949
AMTR_s00012p00240790
W1PDB8
AMTR_s00012p00240790
IUUC-Atr-003064
AMTR_s00012p00240550
W1PJT5
AMTR_s00012p00240550
IUUC-Atr-002690
AMTR_s00155p00037840
W1PIY3
AMTR_s00155p00037840
IUUC-Atr-002962
AMTR_s00053p00115370
W1PAU5
AMTR_s00053p00115370
IUUC-Atr-002779
AMTR_s00077p00161250
W1PB67
AMTR_s00077p00161250
IUUC-Atr-002935
AMTR_s00077p00028380
W1P924
AMTR_s00077p00028380
IUUC-Atr-002736
AMTR_s00077p00025220
W1P8V5
AMTR_s00077p00025220
IUUC-Atr-002555
AMTR_s00078p00129860
W1P1W2
AMTR_s00078p00129860
IUUC-Atr-002432
AMTR_s00135p00069650
W1NZ74
AMTR_s00135p00069650
IUUC-Atr-002689
AMTR_s00045p00208580
W1P2S8
AMTR_s00045p00208580
IUUC-Atr-002713
AMTR_s00002p00270710
W1P1J5
AMTR_s00002p00270710
IUUC-Atr-002845
AMTR_s00252p00018000
W1NR05
AMTR_s00252p00018000
IUUC-Atr-002746
AMTR_s00202p00021010
W1NMK5
AMTR_s00202p00021010
IUUC-Atr-003016
AMTR_s00001p00041750
W1NLN2
AMTR_s00001p00041750
IUUC-Atr-002436
AMTR_s00137p00096710
W1NFF3
AMTR_s00137p00096710
IUUC-Atr-003012
AMTR_s00004p00125790
W1NDI7
AMTR_s00004p00125790
IUUC-Atr-002670
AMTR_s00004p00113780
W1NDZ3
AMTR_s00004p00113780
IUUC-Atr-002762
AMTR_s00004p00105320
W1NDY5
AMTR_s00004p00105320