Bos taurus         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 97 genes.  Reviewed (0 or Unreviewed (97Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Bta-013155
ENSBTAG00000047968.1
G3MZE1
BTBD18
IUUC-Bta-013337
ENSBTAG00000046044.1
G3MXM9
IUUC-Bta-013057
ENSBTAG00000018199.4
G3N351
ZBTB8A
IUUC-Bta-013005
ENSBTAG00000018167.3
G3N1Y0
KLHL31
IUUC-Bta-013020
ENSBTAG00000014249.5
G3MYD5
IVNS1ABP
IUUC-Bta-013015
ENSBTAG00000010113.5
G3N2T5
ZBTB24
IUUC-Bta-012739
ENSBTAG00000046185.1
G3X8E7
BTBD7
IUUC-Bta-012897
ENSBTAG00000045601.1
G3MYS7
KCTD21
IUUC-Bta-012358
ENSBTAG00000027064.5
E1BJI4
BTBD11
IUUC-Bta-012819
ENSBTAG00000016186.5
G5E663
IUUC-Bta-012423
ENSBTAG00000038498.2
F1MRS4
ZBTB39
IUUC-Bta-012398
ENSBTAG00000038630.2
G3N1V7
KLHL34
IUUC-Bta-012801
ENSBTAG00000006563.5
A6H7I0
KLHL40; KBTBD5
IUUC-Bta-013567
ENSBTAG00000025130.4
F1ML16
HIC1
IUUC-Bta-013390
ENSBTAG00000038888.2
F1N7I1
ZBTB9
IUUC-Bta-012973
ENSBTAG00000038970.2
F1MB88
ZBTB14
IUUC-Bta-013295
ENSBTAG00000013306.5
E1BJM6
ZBTB7C
IUUC-Bta-012697
ENSBTAG00000039343.2
F1MIV1
ZBTB34
IUUC-Bta-013494
ENSBTAG00000040061.2
F1ME21
ZBTB38
IUUC-Bta-013323
ENSBTAG00000040551.2
F1MAZ0
ZBTB1
IUUC-Bta-012435
ENSBTAG00000035958.3
F1MZJ4
IUUC-Bta-012410
ENSBTAG00000005392.5
E1BDG8
KBTBD3
IUUC-Bta-013307
ENSBTAG00000008908.5
E1BIC9
GZF1
IUUC-Bta-013073
ENSBTAG00000030646.3
F1MWW3
KCTD17
IUUC-Bta-012867
ENSBTAG00000031916.3
G3X7T6
RHOBTB2; LOC785867
IUUC-Bta-012756
ENSBTAG00000013142.5
Q3B7N9
MYNN
IUUC-Bta-012571
ENSBTAG00000018730.5
E1BDX4
ZBTB17
IUUC-Bta-012405
ENSBTAG00000005038.5
G3X7S0
ZBTB42
IUUC-Bta-013075
ENSBTAG00000002291.5
F1MLT2
ZBTB41
IUUC-Bta-013195
ENSBTAG00000021969.5
F1MN31
KLHL29
IUUC-Bta-012441
ENSBTAG00000039815.1
Q0V8G8
ZBTB6; ZNF482
IUUC-Bta-013384
ENSBTAG00000016108.5
F1N4P1
BTBD2
IUUC-Bta-012519
ENSBTAG00000021231.5
F1MR39
KCTD2
IUUC-Bta-013029
ENSBTAG00000006167.5
F1MRM6
KIAA1107
IUUC-Bta-012754
ENSBTAG00000015087.4
E1BK47
KLHL35
IUUC-Bta-012348
ENSBTAG00000004361.3
F1N518
ZBTB37
IUUC-Bta-012491
ENSBTAG00000026716.4
F1MMV0
IBTK
IUUC-Bta-012885
ENSBTAG00000020117.5
E1BIJ8
ZBTB7A
IUUC-Bta-013500
ENSBTAG00000014680.5
E1BHF9
ZBTB49
IUUC-Bta-012893
ENSBTAG00000022656.3
A6QLT0
KCTD6
IUUC-Bta-012900
ENSBTAG00000009210.5
F1MYU9
ZBTB44
IUUC-Bta-012647
ENSBTAG00000005478.5
E1BII2
PATZ1
IUUC-Bta-012811
ENSBTAG00000021696.5
Q28068
CCIN
IUUC-Bta-013174
ENSBTAG00000021512.4
E1BGW3
ZBTB7B
IUUC-Bta-012943
ENSBTAG00000021341.5
F1MZA8
BTBD1
IUUC-Bta-012507
ENSBTAG00000021329.5
F1MXA9
ZBTB3
IUUC-Bta-012930
ENSBTAG00000030836.2
A2VDQ3
ZBTB21; ZNF295
IUUC-Bta-013175
ENSBTAG00000020854.5
E1BGD3
BCL6B
IUUC-Bta-013001
ENSBTAG00000020713.5
E1BIQ6
BACH2
IUUC-Bta-012443
ENSBTAG00000020561.5
F1N776
KLHL15
IUUC-Bta-012908
ENSBTAG00000020490.4
E1BMR0
NACC2
IUUC-Bta-012869
ENSBTAG00000020003.4
E1BPK1
KLHL14
IUUC-Bta-012570
ENSBTAG00000019304.4
F1MQ38
BTBD3
IUUC-Bta-013141
ENSBTAG00000019164.5
F1MIH7
RHOBTB1
IUUC-Bta-012565
ENSBTAG00000018482.5
F1MRW4
KBTBD4
IUUC-Bta-012747
ENSBTAG00000018284.4
E1BF13
KBTBD11
IUUC-Bta-012987
ENSBTAG00000018238.4
A4FV83
ABTB1
IUUC-Bta-012380
ENSBTAG00000017471.3
F1MXY6
KBTBD13
IUUC-Bta-013501
ENSBTAG00000017184.3
A5D7M1
ZBTB33; MGC155143
IUUC-Bta-013111
ENSBTAG00000016829.5
F1MLP0
ZBTB22
IUUC-Bta-013356
ENSBTAG00000016754.4
E1BPK4
KLHL38
IUUC-Bta-012521
ENSBTAG00000016735.5
E1BPM6
ZBTB48
IUUC-Bta-012773
ENSBTAG00000016667.3
E1BM43
ZBTB46
IUUC-Bta-012624
ENSBTAG00000016448.5
F1N193
ZBTB40
IUUC-Bta-012628
ENSBTAG00000016350.4
E1BQ03
NACC1
IUUC-Bta-012415
ENSBTAG00000015982.2
F1N648
KCTD13
IUUC-Bta-012488
ENSBTAG00000014790.4
E1BNH4
ZBTB2
IUUC-Bta-012402
ENSBTAG00000014114.4
F1MNJ8
KLHL26
IUUC-Bta-013355
ENSBTAG00000013460.3
E1BBI5
ZBTB11
IUUC-Bta-013321
ENSBTAG00000012751.5
A1A4N2
BTBD6
IUUC-Bta-012346
ENSBTAG00000011928.4
F1MDT4
ZBTB20
IUUC-Bta-012889
ENSBTAG00000011292.5
E1BLW3
LZTR1
IUUC-Bta-012807
ENSBTAG00000011266.5
Q32PJ4
ZBTB16; BOS_14369
IUUC-Bta-012910
ENSBTAG00000011081.5
F1N465
KBTBD8
IUUC-Bta-013452
ENSBTAG00000010532.4
F2Z4C0
KCTD11
IUUC-Bta-012769
ENSBTAG00000009643.2
E1BFH3
ZBTB25
IUUC-Bta-013146
ENSBTAG00000008385.4
E1BDD0
KLHL36
IUUC-Bta-012689
ENSBTAG00000008289.5
F1MFQ4
ZBTB4
IUUC-Bta-013551
ENSBTAG00000008115.5
E1BLB2
TNFAIP1
IUUC-Bta-012316
ENSBTAG00000007761.3
A0JN94
ZBTB5
IUUC-Bta-012685
ENSBTAG00000006647.5
F1MCW5
RCBTB2
IUUC-Bta-013484
ENSBTAG00000006186.5
E1BNC2
KCTD3
IUUC-Bta-013162
ENSBTAG00000005951.5
E1BDC0
HIC2
IUUC-Bta-013089
ENSBTAG00000005923.5
E1BMN7
ABTB2
IUUC-Bta-012690
ENSBTAG00000004755.5
A3KMV1
SHKBP1
IUUC-Bta-013472
ENSBTAG00000004509.5
F1N7Q0
SLX4; BTBD12; BOS_22567
IUUC-Bta-013209
ENSBTAG00000004413.5
F1MSG8
RHOBTB3
IUUC-Bta-012599
ENSBTAG00000004139.2
E1BJL3
BACH1
IUUC-Bta-013409
ENSBTAG00000003438.2
Q58DD1
ZBTB43; ZNF297B
IUUC-Bta-012861
ENSBTAG00000003339.5
F1MZB7
ZBTB10
IUUC-Bta-013372
ENSBTAG00000002697.5
A6QLV6
KCTD10
IUUC-Bta-012576
ENSBTAG00000001511.4
E1B8E6
BCL6
IUUC-Bta-012653
ENSBTAG00000001183.5
F1MIH3
KLHL33
IUUC-Bta-012777
ENSBTAG00000001108.5
F1MJQ9
GMCL1
IUUC-Bta-013238
ENSBTAG00000040575.1
A5PKG7
KCTD5
IUUC-Bta-012635
ENSBTAG00000000529.5
F1MS09
IUUC-Bta-013254
ENSBTAG00000000385.5
A0A140T829
ZBTB18