Brachypodium distachyon         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 66 genes.  Reviewed (0 or Unreviewed (66Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Bdi-014473
BRADI5G24790
I1J2W2
IUUC-Bdi-014147
BRADI5G22400
I1J215
BRADI_5g22400
IUUC-Bdi-014412
BRADI5G22375
I1J212
LOC100832913
IUUC-Bdi-014711
BRADI5G22370
I1J211
IUUC-Bdi-014684
BRADI5G22362
I1J210
LOC100832289; BRADI_5g22362
IUUC-Bdi-014558
BRADI5G22356
I1J209
LOC100831998
IUUC-Bdi-014191
BRADI5G22350
I1J208
LOC100830784
IUUC-Bdi-014556
BRADI5G13663
I1IYY3
LOC100823533; BRADI_5g13663
IUUC-Bdi-014510
BRADI5G09870
I1IXN4
LOC100833657
IUUC-Bdi-014661
BRADI4G43150
I1IUK0
LOC100832708; BRADI_4g43150
IUUC-Bdi-014779
BRADI4G38300
I1ISY6
IUUC-Bdi-014457
BRADI4G33580
I1IR77
LOC100828628; BRADI_4g33580
IUUC-Bdi-014812
BRADI4G30480
I1IQ70
LOC100842389; BRADI_4g30480
IUUC-Bdi-014297
BRADI4G25540
I1INH3
LOC100844808; BRADI_4g25540
IUUC-Bdi-014853
BRADI4G23840
I1IMZ1
LOC100830561
IUUC-Bdi-014822
BRADI4G23830
I1IMZ0
LOC100831668; BRADI_4g23830
IUUC-Bdi-014380
BRADI4G23820
I1IMY9
BRADI_4g23820
IUUC-Bdi-014885
BRADI4G23737
I1IMY0
LOC100829223; BRADI_4g23737
IUUC-Bdi-014909
BRADI4G23730
I1IMX9
LOC100829952; BRADI_4g23730
IUUC-Bdi-014434
BRADI4G15130
I1IKT6
LOC100827716; BRADI_4g15130
IUUC-Bdi-014060
BRADI4G12915
I1IK61
LOC100834128
IUUC-Bdi-014278
BRADI4G12910
I1IK60
LOC100825145; BRADI_4g12910
IUUC-Bdi-014173
BRADI4G12820
I1IK51
BRADI_4g12820
IUUC-Bdi-014133
BRADI3G54372
I1IDJ9
LOC100829921
IUUC-Bdi-014840
BRADI3G46480
I1IAS1
LOC100831661; BRADI_3g46480
IUUC-Bdi-014148
BRADI3G41290
I1I8X6
BRADI_3g41290
IUUC-Bdi-014045
BRADI3G40777
I1I8R7
LOC100828405; BRADI_3g40777
IUUC-Bdi-014919
BRADI3G40767
I1I8R6
LOC100827490
IUUC-Bdi-014524
BRADI3G40760
I1I8R5
LOC100827176
IUUC-Bdi-014136
BRADI3G40745
I1I8R3
BRADI_3g40745
IUUC-Bdi-015003
BRADI3G40730
I1I8R1
LOC100825623
IUUC-Bdi-014873
BRADI3G40720
I1I8R0
IUUC-Bdi-015026
BRADI3G40527
I1I8N4
LOC100831968; BRADI_3g40527
IUUC-Bdi-014878
BRADI3G27081
I1I447
IUUC-Bdi-014284
BRADI3G27074
I1I446
LOC100841545; BRADI_3g27074
IUUC-Bdi-014693
BRADI3G27067
I1I445
LOC100830648; BRADI_3g27067
IUUC-Bdi-014287
BRADI3G18640
I1I265
LOC100845302
IUUC-Bdi-014576
BRADI3G18410
I1I236
LOC100837087; BRADI_3g18410
IUUC-Bdi-014748
BRADI3G18370
I1I232
LOC100836160; BRADI_3g18370
IUUC-Bdi-014743
BRADI3G18357
I1I231
LOC100843891; BRADI_3g18357
IUUC-Bdi-014246
BRADI3G13110
I1I0A6
LOC100825528; BRADI_3g13110
IUUC-Bdi-014285
BRADI3G12700
I1I052
LOC100832777
IUUC-Bdi-014948
BRADI3G09770
I1HZC7
LOC100826874; BRADI_3g09770
IUUC-Bdi-014288
BRADI2G61167
I1HVB9
BRADI_2g61167
IUUC-Bdi-014484
BRADI2G60710
I1HV69
LOC100831525; BRADI_2g60710
IUUC-Bdi-014500
BRADI2G59770
I1HUW3
LOC100840904; BRADI_2g59770
IUUC-Bdi-014820
BRADI2G51030
I1HS07
LOC100836959; BRADI_2g51030
IUUC-Bdi-014972
BRADI2G26076
I1HJN6
IUUC-Bdi-014610
BRADI2G05870
I1HCY0
LOC100820989; BRADI_2g05870
IUUC-Bdi-014943
BRADI1G77537
I1HAJ3
LOC100822714; BRADI_1g77537
IUUC-Bdi-014047
BRADI1G65350
I1H6I1
LOC100826585; BRADI_1g65350
IUUC-Bdi-014327
BRADI1G59760
I1H4I9
LOC100828421; BRADI_1g59760
IUUC-Bdi-014094
BRADI1G56600
I1H3F5
LOC100828625; BRADI_1g56600
IUUC-Bdi-014081
BRADI1G56500
I1H3E2
LOC100826375; BRADI_1g56500
IUUC-Bdi-014360
BRADI1G55640
I1H356
LOC100837814; BRADI_1g55640
IUUC-Bdi-014358
BRADI1G53140
I1H2C6
LOC100837201; BRADI_1g53140
IUUC-Bdi-014963
BRADI1G52450
I1H251
LOC100844739; BRADI_1g52450
IUUC-Bdi-014977
BRADI1G42730
I1GYR7
LOC100839470; BRADI_1g42730
IUUC-Bdi-014155
BRADI1G39260
I1GYC5
LOC100838070; BRADI_1g39260
IUUC-Bdi-014792
BRADI1G32690
I1GW60
IUUC-Bdi-014230
BRADI1G19390
I1GRP2
LOC100834579; BRADI_1g19390
IUUC-Bdi-014611
BRADI1G12870
I1GPQ3
LOC100832726; BRADI_1g12870
IUUC-Bdi-014482
BRADI1G06070
I1GME5
LOC100840246; BRADI_1g06070
IUUC-Bdi-014856
BRADI1G05397
I1GM66
LOC100836197; BRADI_1g05397
IUUC-Bdi-014667
BRADI1G02840
I1GL90
IUUC-Bdi-014835
BRADI1G02830
I1GL89