Caenorhabditis elegans         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 82 genes.  Reviewed (7 or Unreviewed (75Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Cel-018222
WBGene00022573
P91563
ZC239.15; CELE_ZC239.15
IUUC-Cel-018556
WBGene00010193
O45593
btb-20; CELE_F57C2.1; F57C2.1
IUUC-Cel-018444
WBGene00008425
Q18986
D2045.8; CELE_D2045.8
IUUC-Cel-018133
WBGene00016871
Q18776
inso-1; C52B11.2; CELE_C52B11.2
IUUC-Cel-018427
WBGene00015914
Q965M5
C17F4.8; CELE_C17F4.8
IUUC-Cel-018279
WBGene00015590
P34324
bath-15; C08C3.2
IUUC-Cel-018391
WBGene00015112
O16612
B0281.5; CELE_B0281.5
IUUC-Cel-018666
WBGene00022569
P91556
ZC239.6; CELE_ZC239.6
IUUC-Cel-018185
WBGene00022568
P91557
ZC239.5; CELE_ZC239.5
IUUC-Cel-018559
WBGene00022567
P91558
ZC239.4; CELE_ZC239.4
IUUC-Cel-018386
WBGene00022566
P91559
ZC239.3; CELE_ZC239.3
IUUC-Cel-018381
WBGene00022574
P91564
ZC239.16; CELE_ZC239.16
IUUC-Cel-018586
WBGene00022572
P91561
ZC239.14; CELE_ZC239.14
IUUC-Cel-018139
WBGene00022571
C8JQQ4
ZC239.13; CELE_ZC239.13
IUUC-Cel-018696
WBGene00022570
P91555
sdz-35; CELE_ZC239.12; ZC239.12
IUUC-Cel-018174
WBGene00013569
Q9XWB9
bath-36; Y75B12B.4
IUUC-Cel-018520
WBGene00013382
Q9U1W5
gcl-1; CELE_Y62E10A.16; Y62E10A.16
IUUC-Cel-018516
WBGene00044346
Q4W5R6
Y59E9AL.8; CELE_Y59E9AL.8
IUUC-Cel-018288
WBGene00021853
Q9BKZ7
Y54F10AM.11; CELE_Y54F10AM.11
IUUC-Cel-018380
WBGene00021727
Q9TYJ2
bath-23; CELE_Y49F6C.5; Y49F6C.5
IUUC-Cel-018492
WBGene00021726
Q9TYJ1
bath-10; CELE_Y49F6C.4; Y49F6C.4
IUUC-Cel-018337
WBGene00021725
Q9TYJ0
bath-9; CELE_Y49F6C.3; Y49F6C.3
IUUC-Cel-018488
WBGene00012825
Q9XWN3
Y43F8C.3; CELE_Y43F8C.3
IUUC-Cel-018120
WBGene00012322
G5EEX6
W07A12.4; CELE_W07A12.4
IUUC-Cel-018679
WBGene00021042
O44905
btb-5; CELE_W05G11.5; W05G11.5
IUUC-Cel-018543
WBGene00012196
Q9XUM9
bath-35; CELE_W02A11.8; W02A11.8
IUUC-Cel-018622
WBGene00002185
Q8WQC4
kel-3; CELE_T27E9.4; T27E9.4
IUUC-Cel-018127
WBGene00020859
Q9TZM5
bath-25; CELE_T27C10.4; T27C10.4
IUUC-Cel-018507
WBGene00020802
Q8IFY9
btb-2; CELE_T25D10.5; T25D10.5
IUUC-Cel-018212
WBGene00020721
O17001
T23B12.6; CELE_T23B12.6
IUUC-Cel-018671
WBGene00011815
P34568
bath-43; T16H12.5
IUUC-Cel-018597
WBGene00011621
Q7YWU7
T08G3.13; CELE_T08G3.13
IUUC-Cel-018608
WBGene00020325
O76610
bath-46; CELE_T07H3.2; T07H3.2
IUUC-Cel-018373
WBGene00006464
O76612
bath-47; T07H3.1
IUUC-Cel-018538
WBGene00011486
Q9XUR6
T05E12.3; CELE_T05E12.3
IUUC-Cel-018611
WBGene00020073
O17297
sdz-28; CELE_R52.1; R52.1
IUUC-Cel-018576
WBGene00011198
Q21899
R10E4.1; CELE_R10E4.1
IUUC-Cel-018672
WBGene00006493
Q21854
tag-147; CELE_R09A8.3; R09A8.3
IUUC-Cel-018654
WBGene00019972
A0A0K3AS98
R09A1.2; CELE_R09A1.2
IUUC-Cel-018284
WBGene00019700
O17223
btb-11; CELE_M01D1.3; M01D1.3
IUUC-Cel-018574
WBGene00045036
Q067Y2
K08E4.7; CELE_K08E4.7
IUUC-Cel-018298
WBGene00019342
O16630
K02F6.8; CELE_K02F6.8
IUUC-Cel-018113
WBGene00019339
O16631
K02F6.5; CELE_K02F6.5
IUUC-Cel-018548
WBGene00019313
O17253
btb-10; CELE_K02E7.9; K02E7.9
IUUC-Cel-018607
WBGene00019139
Q9N5Q0
bath-1; CELE_F59H6.9; F59H6.9
IUUC-Cel-018110
WBGene00019138
Q9N5Q1
bath-21; CELE_F59H6.8; F59H6.8
IUUC-Cel-018401
WBGene00019141
Q9N5P8
bath-5; CELE_F59H6.11; F59H6.11
IUUC-Cel-018282
WBGene00019140
Q9N5P9
bath-3; CELE_F59H6.10; F59H6.10
IUUC-Cel-018554
WBGene00010194
O45594
btb-19; CELE_F57C2.2; F57C2.2
IUUC-Cel-018557
WBGene00009945
Q20681
bath-38; F52H3.3
IUUC-Cel-018601
WBGene00018665
O44815
bath-4; CELE_F52C6.8; F52C6.8
IUUC-Cel-018358
WBGene00018668
O44818
bath-2; CELE_F52C6.11; F52C6.11
IUUC-Cel-018270
WBGene00018667
O44817
bath-7; CELE_F52C6.10; F52C6.10
IUUC-Cel-018351
WBGene00018443
O16740
btb-7; CELE_F45C12.12; F45C12.12
IUUC-Cel-018372
WBGene00018442
A0A131MBE3
sdz-18; CELE_F45C12.11; F45C12.11
IUUC-Cel-018149
WBGene00018441
H2L038
math-29; CELE_F45C12.10; F45C12.10
IUUC-Cel-018233
WBGene00001963
btb-1
IUUC-Cel-018339
WBGene00018223
O76568
bath-13; CELE_F40B1.1; F40B1.1
IUUC-Cel-018477
WBGene00018195
O17112
btb-16; CELE_F39E9.2; F39E9.2
IUUC-Cel-018138
WBGene00018201
Q8ITZ1
btb-18; CELE_F39E9.12; F39E9.12
IUUC-Cel-018184
WBGene00018200
Q8ITZ2
btb-17; CELE_F39E9.11; F39E9.11
IUUC-Cel-018446
WBGene00006415
Q20183
tag-30; CELE_F38H4.7; F38H4.7
IUUC-Cel-018304
WBGene00009247
Q9XV51
bath-45; F29C12.5
IUUC-Cel-018263
WBGene00009064
O45398
F22G12.4; CELE_F22G12.4
IUUC-Cel-018365
WBGene00017707
O16706
F22E5.8; CELE_F22E5.8
IUUC-Cel-018534
WBGene00017705
O16711
F22E5.6; CELE_F22E5.6
IUUC-Cel-018458
WBGene00017710
O16709
F22E5.12; CELE_F22E5.12
IUUC-Cel-018252
WBGene00017452
O44805
bath-29; CELE_F14D2.4; F14D2.4
IUUC-Cel-018289
WBGene00017460
Q8MXH8
bath-30; CELE_F14D2.12; F14D2.12
IUUC-Cel-018259
WBGene00017405
Q9BLC3
bath-31; CELE_F12E12.4; F12E12.4
IUUC-Cel-018196
WBGene00016550
Q9TZA6
C40A11.7; CELE_C40A11.7
IUUC-Cel-018338
WBGene00016549
Q9TZA8
C40A11.6; CELE_C40A11.6
IUUC-Cel-018531
WBGene00016547
Q9TZB0
C40A11.4; CELE_C40A11.4
IUUC-Cel-018383
WBGene00016546
Q9TZA9
C40A11.3; CELE_C40A11.3
IUUC-Cel-018359
WBGene00016545
Q9TZA7
C40A11.2; CELE_C40A11.2
IUUC-Cel-018319
WBGene00015798
Q18030
C15H9.2; CELE_C15H9.2
IUUC-Cel-018501
WBGene00015595
O17193
bath-33; C08E3.3; CELE_C08E3.3
IUUC-Cel-018384
WBGene00015594
A0A131MD04
btb-15; btb-22; CELE_F39E9.27; F39E9.27
IUUC-Cel-018453
WBGene00015463
O16313
hpo-9; C05C8.6; CELE_C05C8.6
IUUC-Cel-018126
WBGene00015113
O16613
B0281.6; CELE_B0281.6
IUUC-Cel-018497
WBGene00015014
O16566
bath-24; B0047.3; CELE_B0047.3
IUUC-Cel-018583
WBGene00015012
Q3V5H9
bath-20; B0047.1; CELE_B0047.1