Chlamydomonas reinhardtii         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 27 genes.  Reviewed (0 or Unreviewed (27Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Cre-022559
CHLREDRAFT_146860
A8HN78
CHLREDRAFT_146860
IUUC-Cre-022674
CHLREDRAFT_146398
A8HPZ0
CHLREDRAFT_146398
IUUC-Cre-022779
CHLREDRAFT_188044
A8HU48
CHLREDRAFT_188044
IUUC-Cre-022654
CHLREDRAFT_166883
A8I4T4
CHLREDRAFT_166883
IUUC-Cre-022892
CHLREDRAFT_186922
A8I4S8
MRS1; CHLREDRAFT_186922
IUUC-Cre-022656
CHLREDRAFT_143897
A8IE83
CHLREDRAFT_143897
IUUC-Cre-022758
CHLREDRAFT_145759
A8ISX3
CHLREDRAFT_145759
IUUC-Cre-022976
CHLREDRAFT_189391
A8ISS0
CHLREDRAFT_189391
IUUC-Cre-022672
CHLREDRAFT_11662
A8ISR9
DNJ30; CHLREDRAFT_11662
IUUC-Cre-022843
CHLREDRAFT_170897
A8ISN9
CHLREDRAFT_170897
IUUC-Cre-023017
CHLREDRAFT_190323
A8IVT1
CHLREDRAFT_190323
IUUC-Cre-022943
CHLREDRAFT_173207
A8IY01
CHLREDRAFT_173207
IUUC-Cre-022782
CHLREDRAFT_192674
A8J618
CHLREDRAFT_192674
IUUC-Cre-022652
CHLREDRAFT_151197
A8J759
CHLREDRAFT_151197
IUUC-Cre-022591
CHLREDRAFT_151030
A8J7W8
CHLREDRAFT_151030
IUUC-Cre-022666
CHLREDRAFT_151334
A8J915
CHLREDRAFT_151334
IUUC-Cre-022832
CHLREDRAFT_193146
A8J9C7
CHLREDRAFT_193146
IUUC-Cre-022766
CHLREDRAFT_151805
A8J9W3
CHLREDRAFT_151805
IUUC-Cre-022754
CHLREDRAFT_193279
A8J9V6
CHLREDRAFT_193279
IUUC-Cre-022573
CHLREDRAFT_193262
A8J9U1
CHLREDRAFT_193262
IUUC-Cre-022750
CHLREDRAFT_151740
A8J9R0
CHLREDRAFT_151740
IUUC-Cre-022700
CHLREDRAFT_152724
A8JCI9
CHLREDRAFT_152724
IUUC-Cre-022671
CHLREDRAFT_153097
A8JD52
CHLREDRAFT_153097
IUUC-Cre-022884
CHLREDRAFT_194479
A8JEW7
CHLREDRAFT_194479
IUUC-Cre-022991
CHLREDRAFT_140706
A8JIB4
CHLREDRAFT_140706
IUUC-Cre-022734
CHLREDRAFT_195309
A8JJC5
CHLREDRAFT_195309
IUUC-Cre-022761
CHLREDRAFT_195341
A8JK33
CHLREDRAFT_195341