Ciona savignyi         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 39 genes.  Reviewed (0 or Unreviewed (39Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Csv-026204
ENSCSAVG00000011339.1
H2ZP04
IUUC-Csv-026349
ENSCSAVG00000010769.1
H2ZL69
IUUC-Csv-026281
ENSCSAVG00000010257.1
H2ZIJ9
IUUC-Csv-026378
ENSCSAVG00000010229.1
H2ZIF3
IUUC-Csv-026166
ENSCSAVG00000009825.1
H2ZGJ1
IUUC-Csv-026004
ENSCSAVG00000009742.1
H2ZG50
IUUC-Csv-026025
ENSCSAVG00000008896.1
H2ZC54
IUUC-Csv-026159
ENSCSAVG00000008661.1
H2ZB43
IUUC-Csv-025840
ENSCSAVG00000007915.1
H2Z7E1
IUUC-Csv-026323
ENSCSAVG00000007743.1
H2Z6H8
IUUC-Csv-026142
ENSCSAVG00000007242.1
H2Z3Z8
IUUC-Csv-025860
ENSCSAVG00000006275.1
H2YZB4
IUUC-Csv-026254
ENSCSAVG00000006228.1
H2YZ27
IUUC-Csv-026178
ENSCSAVG00000006130.1
H2YYI8
IUUC-Csv-026147
ENSCSAVG00000005947.1
H2YXM1
IUUC-Csv-026343
ENSCSAVG00000005761.1
H2YWV3
IUUC-Csv-025878
ENSCSAVG00000005657.1
H2YWC7
IUUC-Csv-026375
ENSCSAVG00000005445.1
H2YV76
IUUC-Csv-025881
ENSCSAVG00000005295.1
H2YUE3
IUUC-Csv-025912
ENSCSAVG00000005292.1
H2YUE0
IUUC-Csv-026076
ENSCSAVG00000004626.1
H2YQY1
IUUC-Csv-026325
ENSCSAVG00000003576.1
H2YKZ3
IUUC-Csv-026126
ENSCSAVG00000003552.1
H2YKV9
IUUC-Csv-025928
ENSCSAVG00000003072.1
H2YIJ6
IUUC-Csv-026272
ENSCSAVG00000002460.1
H2YFT0
IUUC-Csv-026277
ENSCSAVG00000002457.1
H2YFS7
IUUC-Csv-026217
ENSCSAVG00000002374.1
H2YFB9
IUUC-Csv-026044
ENSCSAVG00000001978.1
H2YDC2
IUUC-Csv-026351
ENSCSAVG00000001885.1
H2YCX2
IUUC-Csv-026261
ENSCSAVG00000001544.1
H2YBB2
IUUC-Csv-026041
ENSCSAVG00000001540.1
H2YBA8
IUUC-Csv-025948
ENSCSAVG00000001533.1
H2YB95
IUUC-Csv-026106
ENSCSAVG00000001481.1
H2YB14
IUUC-Csv-026062
ENSCSAVG00000001246.1
H2Y9X1
IUUC-Csv-026077
ENSCSAVG00000001019.1
H2Y8U9
IUUC-Csv-026056
ENSCSAVG00000000964.1
H2Y8L8
IUUC-Csv-026045
ENSCSAVG00000000737.1
H2Y7N4
IUUC-Csv-025932
ENSCSAVG00000000460.1
H2Y664
IUUC-Csv-025875
ENSCSAVG00000000044.1
H2Y452