Danio rerio         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 107 genes.  Reviewed (0 or Unreviewed (107Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Dre-027993
ENSDARG00000063040.6
A0A0R4IM56
btbd11b
IUUC-Dre-027796
ENSDARG00000036235.6
A0A0R4IWF3
zbtb3
IUUC-Dre-028412
ENSDARG00000103802.1
E7F661
si:ch73-389b16.2
IUUC-Dre-028574
ENSDARG00000078238.3
A0A0R4IHV2
nacc1
IUUC-Dre-028629
ENSDARG00000028228.8
Q1L8W0
zbtb18; znf238; si:ch211-221n23.1
IUUC-Dre-027417
ENSDARG00000098273.1
Q7SYJ3
zbtb14; zfp161; zgc:66442
IUUC-Dre-027453
ENSDARG00000078191.5
A0A0R4IM01
zbtb46
IUUC-Dre-027866
ENSDARG00000002196.8
A0A0R4IMQ3
bach1b
IUUC-Dre-028348
ENSDARG00000102111.1
A0A0R4IKZ8
zbtb49
IUUC-Dre-027555
ENSDARG00000101942.1
A0A0R4IAE5
si:dkey-260j18.2
IUUC-Dre-027649
ENSDARG00000100607.1
A0A0R4IVZ9
zbtb38
IUUC-Dre-027794
ENSDARG00000100985.1
E7EYJ5
ZBTB7C; zbtb7c
IUUC-Dre-028050
ENSDARG00000104958.2
A0A0G2KCC7
kbtbd11
IUUC-Dre-027672
ENSDARG00000100497.1
Q90W33
hic2; hrg22
IUUC-Dre-028546
ENSDARG00000099164.1
A0A0G2L3U3
NACC1 (1 of many); LOC103910274
IUUC-Dre-028636
ENSDARG00000104653.1
A0A0G2KCJ6
BTBD2 (1 of many); btbd2
IUUC-Dre-028372
ENSDARG00000103949.1
Q1LWQ4
zbtb12.1; si:ch211-222e23.6; CH211-222E23.6-001
IUUC-Dre-027729
ENSDARG00000105050.1
E7FFI2
SHKBP1; shkbp1
IUUC-Dre-027378
ENSDARG00000102761.1
A0A0R4IL97
zbtb42
IUUC-Dre-028086
ENSDARG00000036569.6
X1WCB1
bach2a
IUUC-Dre-028776
ENSDARG00000076584.3
X1WGP9
patz1
IUUC-Dre-027783
ENSDARG00000074526.3
E7FGS1
zbtb16b
IUUC-Dre-028155
ENSDARG00000062553.7
X1WBY6
bach1a
IUUC-Dre-028100
ENSDARG00000040278.6
X1WG55
klhl38b
IUUC-Dre-027381
ENSDARG00000056050.6
U3JA92
kctd17; si:ch73-139e5.3
IUUC-Dre-028240
ENSDARG00000095912.2
F8W3L3
si:dkey-229b18.3
IUUC-Dre-027552
ENSDARG00000003069.8
Q5TZA6
btbd7
IUUC-Dre-028838
ENSDARG00000067751.5
E9QHV0
si:rp71-68n21.9
IUUC-Dre-027491
ENSDARG00000057751.7
B8JL75
zbtb47a; si:ch211-145c23.4
IUUC-Dre-027659
ENSDARG00000042383.7
Q5RIH3
zbtb25
IUUC-Dre-027520
ENSDARG00000069295.5
A5WWI3
bcl6ab
IUUC-Dre-027795
ENSDARG00000015905.9
F1R533
lztr1
IUUC-Dre-028649
ENSDARG00000043285.7
F1QC37
zbtb21; znf295
IUUC-Dre-027582
ENSDARG00000017115.9
Q6P7X5
kctd10
IUUC-Dre-027503
ENSDARG00000045983.4
A2BGW8
zbtb43; si:rp71-14i8.2
IUUC-Dre-028421
ENSDARG00000013492.7
B0V1A3
zbtb34
IUUC-Dre-028449
ENSDARG00000004074.7
Q5RIW6
bach2b; bach2
IUUC-Dre-027605
ENSDARG00000070864.7
F1R5N6
bcl6a
IUUC-Dre-027534
ENSDARG00000090687.2
F1QWN9
rcbtb2
IUUC-Dre-028661
ENSDARG00000039066.7
Q6Q7X9
klhl31; kbtbd1; klhl
IUUC-Dre-028307
ENSDARG00000087517.2
F1QF46
btbd3b; si:dkey-246k9.2
IUUC-Dre-028395
ENSDARG00000088807.4
F1Q9R3
klhl22
IUUC-Dre-028535
ENSDARG00000091762.2
E7F660
zbtb40
IUUC-Dre-028133
ENSDARG00000079468.3
E7FDG6
RHOBTB1; rhobtb1
IUUC-Dre-028304
ENSDARG00000090036.4
E7EYA0
RHOBTB3; si:dkey-6b12.5
IUUC-Dre-028000
ENSDARG00000089340.2
E7F6W1
rhobtb2b
IUUC-Dre-027626
ENSDARG00000059226.5
F1RE12
zbtb8a
IUUC-Dre-027469
ENSDARG00000074548.4
E7F500
zbtb17
IUUC-Dre-027465
ENSDARG00000074424.4
E7FD71
ibtk
IUUC-Dre-028553
ENSDARG00000076380.3
F1QSF5
hnrnpa0l
IUUC-Dre-027561
ENSDARG00000077101.4
A5PMB0
zbtb10; si:dkeyp-34f6.1
IUUC-Dre-028178
ENSDARG00000003251.10
Q1LUU5
zbtb22b; zbtb22; znf297; DKEY-264N13.3-001
IUUC-Dre-028002
ENSDARG00000017886.10
F1RAC1
zbtb11; si:dkeyp-116g9.2
IUUC-Dre-027436
ENSDARG00000063354.5
E7F920
abtb1
IUUC-Dre-027761
ENSDARG00000077425.2
E7FCD3
NACC2; LOC559520
IUUC-Dre-028277
ENSDARG00000075533.3
E7F443
zbtb24
IUUC-Dre-028102
ENSDARG00000074828.4
F1QA56
RHOBTB2 (1 of many); si:dkey-263f15.2
IUUC-Dre-028165
ENSDARG00000071467.5
A8DU70
zbtb33
IUUC-Dre-027596
ENSDARG00000070658.4
Q1LWQ5
zbtb12.2; si:ch211-222e23.7; CH211-222E23.7-001
IUUC-Dre-027367
ENSDARG00000076440.1
F1QZ02
btbd6a
IUUC-Dre-028433
ENSDARG00000035889.6
Q1LUJ6
zbtb8b; zgc:110075
IUUC-Dre-028173
ENSDARG00000069335.5
F1QFS4
bcl6b
IUUC-Dre-027414
ENSDARG00000069271.5
Q1LUF9
kbtbd4
IUUC-Dre-028362
ENSDARG00000068983.5
F1QLH3
btbd9
IUUC-Dre-028729
ENSDARG00000068400.4
F1QE43
znf131
IUUC-Dre-027966
ENSDARG00000021209.10
F1Q5M1
kctd9a
IUUC-Dre-027547
ENSDARG00000063255.7
Q1LVW0
btbd11a; si:ch211-133h2.1; si:ch211-161f1.1
IUUC-Dre-027529
ENSDARG00000054984.7
F6PFI6
zbtb41
IUUC-Dre-028156
ENSDARG00000062000.6
F1QLH2
abtb2b
IUUC-Dre-027425
ENSDARG00000039899.8
F1R664
zbtb7a
IUUC-Dre-028392
ENSDARG00000061110.7
A2BIA1
zbtb44
IUUC-Dre-028109
ENSDARG00000060854.6
F1Q6W0
kctd3
IUUC-Dre-028297
ENSDARG00000042091.6
Q1LYG7
btbd2a
IUUC-Dre-028355
ENSDARG00000060512.6
X1WEX5
kbtbd3
IUUC-Dre-028571
ENSDARG00000059751.6
E7F2F4
abtb2a
IUUC-Dre-027419
ENSDARG00000057582.3
F1RDT7
KLHL34; klhl34
IUUC-Dre-028333
ENSDARG00000028086.9
F2Z4W3
zbtb2b
IUUC-Dre-028027
ENSDARG00000055493.5
Q70ZY9
hic1
IUUC-Dre-028497
ENSDARG00000053876.5
Q5RGB8
klhl26; si:ch211-255d18.7
IUUC-Dre-027513
ENSDARG00000045660.6
A9JT69
hic1l
IUUC-Dre-027629
ENSDARG00000045275.5
E7FH32
klhl14; si:dkeyp-7a3.2
IUUC-Dre-028747
ENSDARG00000044038.5
F1QX23
zbtb2a
IUUC-Dre-028827
ENSDARG00000043095.4
Q1LVR8
kctd6a; si:dkeyp-87e7.3
IUUC-Dre-027532
ENSDARG00000042689.4
Q1LV62
zbtb37
IUUC-Dre-027945
ENSDARG00000031100.8
Q5RG82
ivns1abpa; si:dkeyp-11g8.1
IUUC-Dre-028837
ENSDARG00000041565.7
F1R5K5
tnfaip1
IUUC-Dre-028368
ENSDARG00000036645.7
B8A4R1
rcbtb1
IUUC-Dre-028345
ENSDARG00000031383.6
Q1LYM6
klhl38a; klhl38; si:dkey-5e12.1
IUUC-Dre-027801
ENSDARG00000016868.9
F1RD19
rhobtb2a
IUUC-Dre-028757
ENSDARG00000032369.10
Q5TZE1
btbd6b; btbd6; si:dkey-11b8.2
IUUC-Dre-028415
ENSDARG00000030251.8
F1QIE0
klhl36
IUUC-Dre-028635
ENSDARG00000025875.8
Q0P490
kctd2; zgc:153278
IUUC-Dre-028113
ENSDARG00000023703.5
Q6DG99
kctd6b; kctd6; zgc:91884
IUUC-Dre-028292
ENSDARG00000021891.7
F1RBL4
zbtb7b
IUUC-Dre-027599
ENSDARG00000015722.9
Q6NYY3
kctd5a; kctd5; zgc:77244
IUUC-Dre-028163
ENSDARG00000013946.7
F1QWA4
ivns1abpb
IUUC-Dre-027363
ENSDARG00000003576.6
F1QSX4
klhl32
IUUC-Dre-027882
ENSDARG00000005544.10
B8JKQ2
btbd3a; btbd3
IUUC-Dre-028517
ENSDARG00000005586.7
F1QRT7
zbtb20
IUUC-Dre-028765
ENSDARG00000020176.7
F1QFB7
CABZ01067086.1; zbtb22a
IUUC-Dre-027623
ENSDARG00000023040.6
Q5RIH1
zbtb1
IUUC-Dre-027842
ENSDARG00000007184.10
E7FDS7
zbtb16a
IUUC-Dre-028648
ENSDARG00000006011.6
Q5RGJ4
klhl42; klhdc5; si:ch211-234f20.7
IUUC-Dre-027466
ENSDARG00000019265.8
F1QNW5
ZBTB39; zbtb39
IUUC-Dre-028593
ENSDARG00000010603.8
A8DZF0
kctd9b
IUUC-Dre-028474
ENSDARG00000001930.9
F1R4M4
klhl15
IUUC-Dre-028047
ENSDARG00000007271.8
F1RES6
mynn