Dasypus novemcinctus         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 91 genes.  Reviewed (0 or Unreviewed (91Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Dno-029607
ENSDNOG00000034053.1
BACH1
IUUC-Dno-029185
ENSDNOG00000046541.1
KLHL14
IUUC-Dno-029912
ENSDNOG00000033922.1
KLHL34
IUUC-Dno-030079
ENSDNOG00000039497.1
KBTBD13
IUUC-Dno-030069
ENSDNOG00000043011.1
IUUC-Dno-029837
ENSDNOG00000042047.1
ABTB1
IUUC-Dno-029780
ENSDNOG00000042939.1
BACH2
IUUC-Dno-029000
ENSDNOG00000045505.1
ZBTB7C
IUUC-Dno-028945
ENSDNOG00000041274.1
IUUC-Dno-029529
ENSDNOG00000042308.1
RHOBTB2
IUUC-Dno-029144
ENSDNOG00000042650.1
KCTD6
IUUC-Dno-029542
ENSDNOG00000034687.1
IUUC-Dno-028939
ENSDNOG00000045311.1
ZBTB41
IUUC-Dno-029271
ENSDNOG00000043735.1
NACC2
IUUC-Dno-029275
ENSDNOG00000047729.1
ZBTB2
IUUC-Dno-029163
ENSDNOG00000033700.1
TNFAIP1
IUUC-Dno-029451
ENSDNOG00000006568.2
RHOBTB3
IUUC-Dno-029503
ENSDNOG00000039528.1
IUUC-Dno-028903
ENSDNOG00000032194.1
ZBTB43
IUUC-Dno-029405
ENSDNOG00000032854.1
ZNF131
IUUC-Dno-029865
ENSDNOG00000037413.1
BTBD11
IUUC-Dno-029132
ENSDNOG00000035663.1
KLHL29
IUUC-Dno-029305
ENSDNOG00000049400.1
IUUC-Dno-029781
ENSDNOG00000036411.1
KBTBD3
IUUC-Dno-029883
ENSDNOG00000034620.1
KLHL30
IUUC-Dno-029614
ENSDNOG00000031877.1
IUUC-Dno-029849
ENSDNOG00000049612.1
ZBTB45
IUUC-Dno-029270
ENSDNOG00000038885.1
IUUC-Dno-029013
ENSDNOG00000035586.1
BCL6B
IUUC-Dno-028864
ENSDNOG00000043591.1
ZBTB7B
IUUC-Dno-029540
ENSDNOG00000037693.1
RCBTB2
IUUC-Dno-029444
ENSDNOG00000038726.1
ZBTB24
IUUC-Dno-029324
ENSDNOG00000023741.2
PDPK1
IUUC-Dno-029721
ENSDNOG00000034417.1
ZBTB4
IUUC-Dno-029394
ENSDNOG00000032353.1
IUUC-Dno-028900
ENSDNOG00000049226.1
HIC1
IUUC-Dno-029711
ENSDNOG00000047356.1
ZBTB16
IUUC-Dno-030021
ENSDNOG00000032935.1
ZBTB8A
IUUC-Dno-029387
ENSDNOG00000037832.1
ZBTB38
IUUC-Dno-029035
ENSDNOG00000043679.1
BTBD3
IUUC-Dno-029375
ENSDNOG00000045164.1
ZBTB46
IUUC-Dno-029909
ENSDNOG00000039247.1
ZBTB33
IUUC-Dno-029452
ENSDNOG00000036619.1
ZBTB7A
IUUC-Dno-029051
ENSDNOG00000035669.1
ZBTB11
IUUC-Dno-029014
ENSDNOG00000045092.1
IUUC-Dno-029059
ENSDNOG00000040899.1
BTBD19
IUUC-Dno-029805
ENSDNOG00000037012.1
ZBTB10
IUUC-Dno-028941
ENSDNOG00000036029.1
BTBD18
IUUC-Dno-029085
ENSDNOG00000042525.1
ZBTB20
IUUC-Dno-029908
ENSDNOG00000037834.1
ZBTB9
IUUC-Dno-028944
ENSDNOG00000024321.1
KCTD13
IUUC-Dno-029600
ENSDNOG00000023966.2
BTBD6
IUUC-Dno-029076
ENSDNOG00000020031.3
KLHL31
IUUC-Dno-029455
ENSDNOG00000019848.3
TEP1
IUUC-Dno-028982
ENSDNOG00000019775.3
KLHL35
IUUC-Dno-029691
ENSDNOG00000018626.3
ABTB2
IUUC-Dno-028848
ENSDNOG00000018524.3
ZBTB34
IUUC-Dno-029339
ENSDNOG00000016261.3
ZBTB49
IUUC-Dno-029224
ENSDNOG00000015051.2
ZBTB1
IUUC-Dno-029716
ENSDNOG00000014591.3
ZBTB6
IUUC-Dno-030090
ENSDNOG00000013186.2
RHOBTB1
IUUC-Dno-028927
ENSDNOG00000011795.3
BTBD7
IUUC-Dno-029959
ENSDNOG00000011583.3
LZTR1
IUUC-Dno-029789
ENSDNOG00000011215.3
ZBTB39
IUUC-Dno-029153
ENSDNOG00000011063.2
KCTD21
IUUC-Dno-029110
ENSDNOG00000010475.3
KLHL36
IUUC-Dno-029411
ENSDNOG00000010294.2
KLHL15
IUUC-Dno-029184
ENSDNOG00000010253.2
ZBTB5
IUUC-Dno-029471
ENSDNOG00000009543.3
KBTBD4
IUUC-Dno-029978
ENSDNOG00000009334.3
ZBTB18
IUUC-Dno-029861
ENSDNOG00000009311.2
ZBTB25
IUUC-Dno-029850
ENSDNOG00000009093.3
NACC1
IUUC-Dno-029107
ENSDNOG00000008957.3
CCIN
IUUC-Dno-029910
ENSDNOG00000007621.3
KCTD10
IUUC-Dno-029376
ENSDNOG00000007085.2
ZBTB37
IUUC-Dno-029049
ENSDNOG00000006546.3
IUUC-Dno-029544
ENSDNOG00000006200.3
ZBTB40
IUUC-Dno-029188
ENSDNOG00000006094.3
IUUC-Dno-029152
ENSDNOG00000005250.3
ZBTB21
IUUC-Dno-029885
ENSDNOG00000004968.3
IBTK
IUUC-Dno-029965
ENSDNOG00000004827.3
KLHL11
IUUC-Dno-029841
ENSDNOG00000004681.3
MYNN
IUUC-Dno-029476
ENSDNOG00000004306.3
BCL6
IUUC-Dno-029919
ENSDNOG00000004094.3
ZBTB48
IUUC-Dno-028988
ENSDNOG00000003183.3
PATZ1
IUUC-Dno-029125
ENSDNOG00000003162.3
HIC2
IUUC-Dno-029798
ENSDNOG00000002406.3
KCTD3
IUUC-Dno-030078
ENSDNOG00000002252.3
IUUC-Dno-029237
ENSDNOG00000001983.3
ZBTB17
IUUC-Dno-028942
ENSDNOG00000001053.3
IUUC-Dno-029879
ENSDNOG00000000298.3
ZBTB44