Gaeumannomyces graminis         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 16 genes.  Reviewed (0 or Unreviewed (16Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Ggr-039817
GGTG_14455
J3PLH8
GGTG_14455
IUUC-Ggr-039934
GGTG_13369
J3PIP0
GGTG_13369
IUUC-Ggr-039827
GGTG_12298
J3PFM3
GGTG_12298
IUUC-Ggr-039811
GGTG_12297
J3PFM2
GGTG_12297
IUUC-Ggr-040079
GGTG_10989
J3PBW5
GGTG_10989
IUUC-Ggr-039933
GGTG_10346
J3PA23
GGTG_10346
IUUC-Ggr-040000
GGTG_08514
J3P4S8
GGTG_08514
IUUC-Ggr-039848
GGTG_08291
J3P455
GGTG_08291
IUUC-Ggr-039802
GGTG_06814
J3NZW7
GGTG_06814
IUUC-Ggr-040046
GGTG_06479
J3NYX8
GGTG_06479
IUUC-Ggr-039747
GGTG_05423
J3NVW1
GGTG_05423
IUUC-Ggr-039918
GGTG_04232
J3NSI0
GGTG_04232
IUUC-Ggr-039868
GGTG_03964
J3NRR4
GGTG_03964
IUUC-Ggr-039784
GGTG_03828
J3NRC4
GGTG_03828
IUUC-Ggr-040083
GGTG_02097
J3NLE8
GGTG_02097
IUUC-Ggr-040105
GGTG_01212
J3NIX8
GGTG_01212