Hordeum vulgare         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 43 genes.  Reviewed (0 or Unreviewed (43Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Hvu-047320
MLOC_8741
M0ZEA7
IUUC-Hvu-047658
MLOC_77821
M0Z6E4
IUUC-Hvu-047199
MLOC_77591
M0Z5T7
IUUC-Hvu-047766
MLOC_71683
M0YQB9
IUUC-Hvu-047460
MLOC_68949
M0YG16
IUUC-Hvu-047438
MLOC_67382
M0YAV2
IUUC-Hvu-047550
MLOC_66873
M0Y912
IUUC-Hvu-047771
MLOC_65501
M0Y3Z6
IUUC-Hvu-047844
MLOC_65358
M0Y3G6
IUUC-Hvu-047611
MLOC_64045
F2E8S0
IUUC-Hvu-047168
MLOC_63674
M0XWD3
IUUC-Hvu-047528
MLOC_63557
F2DGM7
IUUC-Hvu-047725
MLOC_61451
M0XMU1
IUUC-Hvu-047235
MLOC_61364
M0XMK1
IUUC-Hvu-047615
MLOC_61184
M0XLT6
IUUC-Hvu-047388
MLOC_58890
M0XCL8
IUUC-Hvu-047785
MLOC_58170
M0X9N9
IUUC-Hvu-047598
MLOC_5782
M0X895
IUUC-Hvu-047540
MLOC_56605
M0X2Z5
IUUC-Hvu-047081
MLOC_53856
M0WQJ8
IUUC-Hvu-047385
MLOC_51992
M0WJ12
IUUC-Hvu-047716
MLOC_51988
F2D5A1
IUUC-Hvu-047780
MLOC_49413
M0WD84
IUUC-Hvu-047220
MLOC_44910
M0W8I6
IUUC-Hvu-047289
MLOC_39569
F2EC35
IUUC-Hvu-047569
MLOC_39173
M0W011
IUUC-Hvu-047622
MLOC_38270
M0VXR0
IUUC-Hvu-047674
MLOC_37205
M0VTW1
IUUC-Hvu-047477
MLOC_34652
M0VN51
IUUC-Hvu-047840
MLOC_33499
M0VL85
IUUC-Hvu-047242
MLOC_3077
F2CYB6
IUUC-Hvu-047129
MLOC_28409
M0VHC2
IUUC-Hvu-047282
MLOC_26957
M0VG75
IUUC-Hvu-047126
MLOC_2193
M0VBP3
IUUC-Hvu-047234
MLOC_20901
F2E156
IUUC-Hvu-047048
MLOC_18493
M0V545
IUUC-Hvu-047230
MLOC_16761
F2E0D1
IUUC-Hvu-047720
MLOC_15887
M0UZ57
IUUC-Hvu-047552
MLOC_15784
M0UYU8
IUUC-Hvu-047439
MLOC_10753
M0UGH6
IUUC-Hvu-047207
MLOC_10500
F2EI57
IUUC-Hvu-047740
MLOC_10223
M0UEK8
IUUC-Hvu-047852
MLOC_10067
M0UDU8