Macaca mulatta         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 91 genes.  Reviewed (0 or Unreviewed (91Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Mcc-055167
ENSMMUG00000039331.1
F7HLN0
KCTD11; EGK_08118
IUUC-Mcc-055229
ENSMMUG00000048239.1
A0A1D5Q0R9
IUUC-Mcc-055439
ENSMMUG00000042575.1
A0A1D5Q6Y1
ZBTB3
IUUC-Mcc-054738
ENSMMUG00000043211.1
A0A1D5QF50
IUUC-Mcc-054963
ENSMMUG00000022005.2
F6RIC1
ZBTB14; ZFP161
IUUC-Mcc-055226
ENSMMUG00000040001.1
A0A1D5Q2Q5
BTBD19
IUUC-Mcc-055796
ENSMMUG00000004748.3
G7MYA3
ZBTB1; EGK_18283
IUUC-Mcc-054891
ENSMMUG00000017688.3
A0A1D5RIY0
RCBTB2
IUUC-Mcc-054976
ENSMMUG00000037665.1
F6ZZJ5
BTBD3; EGK_02673
IUUC-Mcc-055714
ENSMMUG00000019145.3
A0A1D5QGF7
TNFAIP1
IUUC-Mcc-055544
ENSMMUG00000020797.3
A0A1D5Q4G9
SHKBP1
IUUC-Mcc-055323
ENSMMUG00000002771.3
A0A1D5RKR1
IUUC-Mcc-055681
ENSMMUG00000038340.1
A0A1D5RHW9
IUUC-Mcc-055564
ENSMMUG00000019184.3
A0A1D5QTD3
ANKFY1
IUUC-Mcc-054846
ENSMMUG00000037633.1
F6RME8
KLHL15; EGK_20331
IUUC-Mcc-054864
ENSMMUG00000038374.1
A0A1D5R0D9
KCTD13
IUUC-Mcc-054719
ENSMMUG00000043280.1
G7NEQ0
ZBTB34; EGK_07870
IUUC-Mcc-054981
ENSMMUG00000048710.1
A0A1D5QZR2
HIC1
IUUC-Mcc-054717
ENSMMUG00000019649.3
A0A1D5Q9X2
KCTD10
IUUC-Mcc-055721
ENSMMUG00000007540.3
I2CWQ8
RHOBTB2
IUUC-Mcc-055182
ENSMMUG00000038579.1
A0A1D5QCW7
IUUC-Mcc-055008
ENSMMUG00000014251.3
A0A1D5QB42
ZNF131
IUUC-Mcc-055270
ENSMMUG00000008031.3
A0A1D5QDL7
ZBTB17
IUUC-Mcc-055703
ENSMMUG00000032281.2
A0A1D5RI52
ZBTB48
IUUC-Mcc-055395
ENSMMUG00000020641.3
F7HP86
ZBTB20
IUUC-Mcc-055572
ENSMMUG00000031896.2
F7H0P7
KCTD6
IUUC-Mcc-055723
ENSMMUG00000004053.3
F6W012
ZBTB7B
IUUC-Mcc-055602
ENSMMUG00000021875.3
F6UBH1
MYNN; EGK_11922
IUUC-Mcc-055465
ENSMMUG00000031526.2
F6TJ26
ZBTB38; EGK_12045
IUUC-Mcc-055370
ENSMMUG00000031089.2
F6QHD8
HIC2
IUUC-Mcc-055844
ENSMMUG00000013911.3
F6QCF5
PATZ1
IUUC-Mcc-055510
ENSMMUG00000022944.3
F6ZRT2
ZBTB44; EGK_07099
IUUC-Mcc-055696
ENSMMUG00000018053.3
F7FJA1
ZBTB21
IUUC-Mcc-055644
ENSMMUG00000011095.3
F7ELK8
BACH1; EGK_13335
IUUC-Mcc-055741
ENSMMUG00000011648.3
F7C8S2
KCTD2
IUUC-Mcc-055867
ENSMMUG00000029765.2
G7MRQ8
ZBTB9; EGK_14790
IUUC-Mcc-055501
ENSMMUG00000001634.3
F6VQG7
BTBD9
IUUC-Mcc-054967
ENSMMUG00000029475.2
F7FTH3
ZBTB2; EGK_15251
IUUC-Mcc-055157
ENSMMUG00000008438.3
F6PYI9
ZBTB10
IUUC-Mcc-054899
ENSMMUG00000023789.2
F7HT97
KLHL31; EGK_15025
IUUC-Mcc-055380
ENSMMUG00000023616.3
G7NIF6
ZBTB4; EGK_08129
IUUC-Mcc-055715
ENSMMUG00000023394.3
F7FE79
ZBTB49
IUUC-Mcc-054999
ENSMMUG00000022868.3
H9Z7J7
CCDC69
IUUC-Mcc-054779
ENSMMUG00000022801.3
F6UWZ3
ZBTB37
IUUC-Mcc-054982
ENSMMUG00000022639.3
F7FRD8
KCTD3
IUUC-Mcc-054968
ENSMMUG00000021400.3
F7FD59
RHOBTB1; EGK_19831
IUUC-Mcc-054946
ENSMMUG00000021243.3
F7HRJ7
ZBTB47
IUUC-Mcc-055592
ENSMMUG00000021165.3
F7H8M7
RHOBTB3
IUUC-Mcc-055350
ENSMMUG00000021115.2
F7HU71
ZBTB39; EGK_03821
IUUC-Mcc-055030
ENSMMUG00000020712.2
F6PTC9
ZBTB46
IUUC-Mcc-055897
ENSMMUG00000020482.3
F6VJV3
LZTR1
IUUC-Mcc-055081
ENSMMUG00000018487.3
F6ZZY5
KLHL30
IUUC-Mcc-055818
ENSMMUG00000018618.3
F6XZL9
ZBTB40
IUUC-Mcc-055004
ENSMMUG00000017971.2
H9H3Z0
NACC1
IUUC-Mcc-055058
ENSMMUG00000017894.3
F7F1G9
ZBTB5
IUUC-Mcc-054851
ENSMMUG00000017874.3
F7DPI9
ZBTB45
IUUC-Mcc-055446
ENSMMUG00000017473.3
F7HK74
KCTD21; EGK_06717
IUUC-Mcc-055806
ENSMMUG00000015540.3
F6VPF1
BTBD11
IUUC-Mcc-054929
ENSMMUG00000016268.2
F7GAW9
BCL6B; EGK_08099
IUUC-Mcc-054706
ENSMMUG00000016030.3
F7FRM8
KLHL29; EGK_05101
IUUC-Mcc-055489
ENSMMUG00000015942.3
F7AJD2
KCTD5
IUUC-Mcc-055511
ENSMMUG00000015664.3
F6RDC9
ZBTB18
IUUC-Mcc-055018
ENSMMUG00000015060.3
F6TKM4
ZBTB11
IUUC-Mcc-055598
ENSMMUG00000013884.3
F6R585
IVNS1ABP; EGK_01851
IUUC-Mcc-055221
ENSMMUG00000013828.3
F6SZF7
BTBD6
IUUC-Mcc-055468
ENSMMUG00000013640.3
F7GL45
ZBTB43
IUUC-Mcc-055755
ENSMMUG00000011243.3
F6WWV1
KLHL36
IUUC-Mcc-054996
ENSMMUG00000011076.3
F7FX83
ZBTB33
IUUC-Mcc-054786
ENSMMUG00000010989.3
F7GS68
KBTBD3; EGK_06848
IUUC-Mcc-055614
ENSMMUG00000010749.3
F7FYD2
IBTK
IUUC-Mcc-055129
ENSMMUG00000010214.3
F7HIY6
CCIN
IUUC-Mcc-054965
ENSMMUG00000010151.3
F6QPZ2
KCTD9
IUUC-Mcc-055251
ENSMMUG00000009736.3
F6ZW90
BACH2; EGK_15169
IUUC-Mcc-055290
ENSMMUG00000009198.3
F7HM62
BCL6; EGK_12203
IUUC-Mcc-055147
ENSMMUG00000008440.2
F6V3Z6
LOC702183; EGK_17209
IUUC-Mcc-055080
ENSMMUG00000008190.3
F7GYL4
IUUC-Mcc-054621
ENSMMUG00000008067.3
F7H162
IUUC-Mcc-055396
ENSMMUG00000007501.3
F6QK71
KLHL34
IUUC-Mcc-054941
ENSMMUG00000007085.3
F7ES08
ZBTB16; EGK_06914
IUUC-Mcc-054659
ENSMMUG00000022387.3
F7H3Y8
GZF1
IUUC-Mcc-055675
ENSMMUG00000005093.3
F7C3U2
KLHL32
IUUC-Mcc-055704
ENSMMUG00000004747.2
F6SU21
ZBTB25
IUUC-Mcc-055792
ENSMMUG00000004289.3
F6ZLW7
KBTBD4
IUUC-Mcc-055194
ENSMMUG00000004028.3
F6XG13
KBTBD13
IUUC-Mcc-055838
ENSMMUG00000004027.3
H9FX03
BTBD7
IUUC-Mcc-054995
ENSMMUG00000003876.3
F7H7T2
ZBTB22; EGK_14784
IUUC-Mcc-055866
ENSMMUG00000003678.3
F6SP12
ZBTB24
IUUC-Mcc-055433
ENSMMUG00000001047.3
F6QNH1
ZBTB42
IUUC-Mcc-055428
ENSMMUG00000000496.2
F6YI93
ZBTB6; EGK_07340
IUUC-Mcc-055242
ENSMMUG00000000166.3
F7HLU6
ABTB1
IUUC-Mcc-055528
ENSMMUG00000000149.3
F7HM03
KCTD17