Magnaporthe poae         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 9 genes.  Reviewed (0 or Unreviewed (9Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Mpo-057377
MAPG_09966
A0A0C4EBB8
MAPG_09966
IUUC-Mpo-057626
MAPG_09592
A0A0C4EAC6
MAPG_09592
IUUC-Mpo-057526
MAPG_09591
A0A0C4EAC5
MAPG_09591
IUUC-Mpo-057627
MAPG_08233
A0A0C4E6T7
MAPG_08233
IUUC-Mpo-057382
MAPG_07131
A0A0C4E3V6
MAPG_07131
IUUC-Mpo-057379
MAPG_04685
A0A0C4DXE0
MAPG_04685
IUUC-Mpo-057466
MAPG_03764
A0A0C4DUW9
MAPG_03764
IUUC-Mpo-057397
MAPG_02507
A0A0C4DRJ7
MAPG_02507
IUUC-Mpo-057374
MAPG_00187
A0A0C4DKB9
MAPG_00187