Oryza barthii         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 68 genes.  Reviewed (0 or Unreviewed (68Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Oba-075862
OBART12G00520
A0A0D3HQK2
IUUC-Oba-075671
OBART11G22830
A0A0D3HPY8
IUUC-Oba-075117
OBART11G20330
A0A0D3HP52
IUUC-Oba-075561
OBART11G20120
A0A0D3HP31
IUUC-Oba-075062
OBART11G19970
A0A0D3HP15
IUUC-Oba-075657
OBART11G18270
A0A0D3HNG2
IUUC-Oba-074999
OBART11G11730
A0A0D3HL98
IUUC-Oba-075319
OBART11G02590
A0A0D3HI21
IUUC-Oba-075822
OBART11G00780
A0A0D3HHC9
IUUC-Oba-075389
OBART10G11320
A0A0D3HE30
IUUC-Oba-075307
OBART10G11310
A0A0D3HE29
IUUC-Oba-075123
OBART10G11110
A0A0D3HE09
IUUC-Oba-075650
OBART10G11090
A0A0D3HE07
IUUC-Oba-075054
OBART10G11030
A0A0D3HE02
IUUC-Oba-075547
OBART10G11020
A0A0D3HE01
IUUC-Oba-075473
OBART10G11010
A0A0D3HE00
IUUC-Oba-075545
OBART10G10990
A0A0D3HDZ8
IUUC-Oba-075481
OBART10G10960
A0A0D3HDZ6
IUUC-Oba-075335
OBART10G10950
A0A0D3HDZ5
IUUC-Oba-075387
OBART10G10750
A0A0D3HDX2
IUUC-Oba-074975
OBART10G10710
A0A0D3HDW9
IUUC-Oba-075518
OBART10G10700
A0A0D3HDW8
IUUC-Oba-075808
OBART10G10660
A0A0D3HDW4
IUUC-Oba-075846
OBART10G10610
A0A0D3HDV5
IUUC-Oba-075798
OBART09G06220
A0A0D3H5I2
IUUC-Oba-076003
OBART09G06210
A0A0D3H5I1
IUUC-Oba-075655
OBART09G01830
A0A0D3H406
IUUC-Oba-075478
OBART08G20990
A0A0D3H2B0
IUUC-Oba-075662
OBART08G20980
A0A0D3H2A9
IUUC-Oba-075430
OBART08G20960
A0A0D3H2A7
IUUC-Oba-075313
OBART08G20420
A0A0D3H249
IUUC-Oba-075885
OBART08G20410
A0A0D3H248
IUUC-Oba-075187
OBART08G20400
A0A0D3H247
IUUC-Oba-075369
OBART08G14170
A0A0D3H038
IUUC-Oba-075475
OBART08G14150
A0A0D3H036
IUUC-Oba-075830
OBART08G14140
A0A0D3H035
IUUC-Oba-075217
OBART08G06620
A0A0D3GXM2
IUUC-Oba-075513
OBART08G06530
A0A0D3GXL3
IUUC-Oba-075166
OBART08G00280
A0A0D3GVH4
IUUC-Oba-075938
OBART07G24830
A0A0D3GUF2
IUUC-Oba-075494
OBART07G09350
A0A0D3GPB8
IUUC-Oba-075622
OBART07G04340
A0A0D3GMQ3
IUUC-Oba-075204
OBART07G04180
A0A0D3GMN4
IUUC-Oba-075291
OBART06G24520
A0A0D3GJU4
IUUC-Oba-075373
OBART06G24210
A0A0D3GJQ9
IUUC-Oba-075413
OBART06G24190
A0A0D3GJQ7
IUUC-Oba-075345
OBART06G24160
A0A0D3GJQ4
IUUC-Oba-075684
OBART06G16510
A0A0D3GH75
IUUC-Oba-075254
OBART06G12640
A0A0D3GFX1
IUUC-Oba-075689
OBART05G23070
A0A0D3G9W2
IUUC-Oba-075767
OBART05G23060
A0A0D3G9W1
IUUC-Oba-075861
OBART05G15590
A0A0D3G7C9
IUUC-Oba-075249
OBART05G12530
A0A0D3G6C1
IUUC-Oba-075013
OBART04G28210
A0A0D3G167
IUUC-Oba-075965
OBART03G35410
A0A0D3FPI2
IUUC-Oba-075539
OBART03G30010
A0A0D3FMK0
IUUC-Oba-076002
OBART03G28720
A0A0D3FM62
IUUC-Oba-075522
OBART03G13730
A0A0D3FHA0
IUUC-Oba-075675
OBART03G04570
A0A0D3FE40
IUUC-Oba-075138
OBART03G04560
A0A0D3FE39
IUUC-Oba-075534
OBART03G04280
A0A0D3FE07
IUUC-Oba-075302
OBART02G21130
A0A0D3F6L5
IUUC-Oba-075273
OBART02G13870
A0A0D3F462
IUUC-Oba-075421
OBART02G13850
A0A0D3F460
IUUC-Oba-075908
OBART02G13810
A0A0D3F456
IUUC-Oba-075608
OBART02G11320
A0A0D3F3B0
IUUC-Oba-075300
OBART01G42940
A0A0D3EYA3
IUUC-Oba-075074
OBART01G32300
A0A0D3EUG3