Oryza brachyantha         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 39 genes.  Reviewed (0 or Unreviewed (39Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Obr-076314
OB11G23730
J3N987
IUUC-Obr-076803
OB11G19240
J3N7Y8
IUUC-Obr-076688
OB11G10420
J3N5F6
IUUC-Obr-076473
OB10G18520
J3N2V4
IUUC-Obr-076893
OB10G18350
J3N2T7
IUUC-Obr-076407
OB10G18310
J3N2T3
IUUC-Obr-076754
OB10G18300
J3N2T2
IUUC-Obr-076043
OB10G12800
J3N182
IUUC-Obr-076482
OB09G14080
J3MWM9
IUUC-Obr-076368
OB08G27760
J3MUJ5
IUUC-Obr-076426
OB08G21920
J3MSW2
IUUC-Obr-076247
OB08G21910
J3MSW1
IUUC-Obr-076008
OB08G16590
J3MRD0
IUUC-Obr-076461
OB08G16550
J3MRC6
IUUC-Obr-076310
OB08G16500
J3MRC1
IUUC-Obr-076421
OB08G15680
J3MR39
IUUC-Obr-076091
OB08G12030
J3MQ24
IUUC-Obr-076250
OB07G30000
J3MNL8
IUUC-Obr-076148
OB07G16790
J3MJU7
IUUC-Obr-076031
OB07G13290
J3MIU7
IUUC-Obr-076797
OB07G13170
J3MIT5
IUUC-Obr-076380
OB06G32240
J3MGT0
IUUC-Obr-076361
OB06G31940
J3MGQ0
IUUC-Obr-076420
OB06G24370
J3MEJ3
IUUC-Obr-076877
OB06G21110
J3MDL7
IUUC-Obr-076792
OB05G23500
J3M6X6
IUUC-Obr-076637
OB04G35200
J3M295
IUUC-Obr-076299
OB04G32850
J3M1L0
IUUC-Obr-076222
OB04G23680
J3LYZ3
IUUC-Obr-076778
OB04G20320
J3LY07
IUUC-Obr-076682
OB04G20310
J3LY06
IUUC-Obr-076800
OB04G20300
J3LY05
IUUC-Obr-076750
OB04G20290
J3LY04
IUUC-Obr-076673
OB03G43880
J3LTL2
IUUC-Obr-076036
OB03G23690
J3LMU3
IUUC-Obr-076587
OB02G29880
J3LEC1
IUUC-Obr-076570
OB02G20080
J3LBJ1
IUUC-Obr-076529
OB0077G10030
J3KUS5
IUUC-Obr-076596
OB0047G10090
J3KUC7