Oryza glaberrima         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 76 genes.  Reviewed (0 or Unreviewed (76Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Ogl-077832
ORGLA12G0021800
I1R3W2
IUUC-Ogl-077369
ORGLA12G0004700
I1R3E1
IUUC-Ogl-077039
ORGLA11G0183500
I1R243
IUUC-Ogl-077694
ORGLA11G0167500
I1R1N3
IUUC-Ogl-077465
ORGLA11G0164600
I1R1K4
IUUC-Ogl-077511
ORGLA11G0163800
I1R1J6
IUUC-Ogl-077578
ORGLA11G0153200
I1R190
IUUC-Ogl-077186
ORGLA11G0100900
I1QZR7
IUUC-Ogl-077107
ORGLA11G0023700
I1QXJ5
IUUC-Ogl-077091
ORGLA11G0009500
I1QX53
IUUC-Ogl-077180
ORGLA10G0165000
I1QWR7
IUUC-Ogl-077707
ORGLA10G0164900
I1QWR6
IUUC-Ogl-077884
ORGLA10G0164600
I1QWR3
IUUC-Ogl-076972
ORGLA10G0098800
I1QUV5
IUUC-Ogl-077173
ORGLA10G0097800
I1QUU5
IUUC-Ogl-077423
ORGLA10G0097600
I1QUU3
IUUC-Ogl-077023
ORGLA10G0097400
I1QUU1
IUUC-Ogl-077869
ORGLA10G0096900
I1QUT6
IUUC-Ogl-077078
ORGLA10G0096800
I1QUT5
IUUC-Ogl-077333
ORGLA10G0096500
I1QUT2
IUUC-Ogl-077812
ORGLA10G0096300
I1QUT0
IUUC-Ogl-077943
ORGLA10G0094200
I1QUQ9
IUUC-Ogl-077365
ORGLA10G0093900
I1QUQ6
IUUC-Ogl-077335
ORGLA10G0093600
I1QUQ3
IUUC-Ogl-077856
ORGLA10G0092700
I1QUP4
IUUC-Ogl-077402
ORGLA10G0092300
I1QUP0
IUUC-Ogl-077546
ORGLA10G0092200
I1QUN9
IUUC-Ogl-077796
ORGLA10G0092000
I1QUN7
IUUC-Ogl-077041
ORGLA10G0091900
I1QUN6
IUUC-Ogl-077137
ORGLA10G0091800
I1QUN5
IUUC-Ogl-076967
ORGLA10G0091600
I1QUN3
IUUC-Ogl-077478
ORGLA10G0091400
I1QUN1
IUUC-Ogl-077151
ORGLA10G0091300
I1QUN0
IUUC-Ogl-076979
ORGLA10G0091100
I1QUM8
IUUC-Ogl-076936
ORGLA10G0091000
I1QUM7
IUUC-Ogl-077462
ORGLA09G0045300
I1QN24
IUUC-Ogl-076985
ORGLA09G0045200
I1QN23
IUUC-Ogl-077854
ORGLA08G0185600
I1QKA5
IUUC-Ogl-077218
ORGLA08G0180900
I1QK58
IUUC-Ogl-077160
ORGLA08G0124600
I1QIJ5
IUUC-Ogl-077867
ORGLA08G0124400
I1QIJ3
IUUC-Ogl-077570
ORGLA08G0124300
I1QIJ2
IUUC-Ogl-077476
ORGLA08G0058400
I1QGN3
IUUC-Ogl-077426
ORGLA08G0057900
I1QGM8
IUUC-Ogl-077235
ORGLA08G0057500
I1QGM4
IUUC-Ogl-077674
ORGLA08G0049900
I1QGE8
IUUC-Ogl-077278
ORGLA08G0012200
I1QFC1
IUUC-Ogl-077262
ORGLA08G0012000
I1QFB9
IUUC-Ogl-077704
ORGLA08G0011800
I1QFB7
IUUC-Ogl-077842
ORGLA08G0011700
I1QFB6
IUUC-Ogl-077098
ORGLA07G0220100
I1QGN2
IUUC-Ogl-077297
ORGLA07G0219900
I1QDK7
IUUC-Ogl-077123
ORGLA07G0191500
I1QCS3
IUUC-Ogl-077498
ORGLA07G0079100
G8JBB5
5
IUUC-Ogl-077619
ORGLA07G0035600
I1Q8B4
IUUC-Ogl-077222
ORGLA06G0203200
I1Q4G9
IUUC-Ogl-077273
ORGLA06G0136800
I1Q2K5
IUUC-Ogl-077745
ORGLA06G0012100
I1PZ09
IUUC-Ogl-077807
ORGLA05G0203400
I1PXD6
IUUC-Ogl-077844
ORGLA05G0203300
I1PXD5
IUUC-Ogl-077778
ORGLA05G0134700
I1PVE9
IUUC-Ogl-077234
ORGLA05G0107200
I1PUM4
IUUC-Ogl-077714
ORGLA04G0244800
I1PQH9
IUUC-Ogl-077788
ORGLA04G0230000
I1PQ31
IUUC-Ogl-077536
ORGLA04G0229900
I1PQ30
IUUC-Ogl-077948
ORGLA04G0101400
I1PLE5
IUUC-Ogl-077101
ORGLA04G0101300
I1PLE4
IUUC-Ogl-077703
ORGLA03G0324700
I1PFV1
IUUC-Ogl-077017
ORGLA03G0132500
I1PAC9
IUUC-Ogl-077256
ORGLA02G0182400
I1P1G8
IUUC-Ogl-076964
ORGLA02G0122300
I1NZR7
IUUC-Ogl-077639
ORGLA02G0122000
I1NZR4
IUUC-Ogl-077069
ORGLA02G0101800
I1NZ62
IUUC-Ogl-077085
ORGLA01G0377200
I1NV82
IUUC-Ogl-077188
ORGLA01G0366800
I1NUX8
IUUC-Ogl-077930
ORGLA01G0263100
I1NRZ1