Oryza indica         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 124 genes.  Reviewed (0 or Unreviewed (124Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Oin-079680
BGIOSGA036774
IUUC-Oin-079059
BGIOSGA035636
IUUC-Oin-079782
BGIOSGA035629
IUUC-Oin-080101
BGIOSGA035627
IUUC-Oin-079964
BGIOSGA035587
IUUC-Oin-079175
BGIOSGA035582
IUUC-Oin-079410
BGIOSGA035519
IUUC-Oin-080174
BGIOSGA035203
IUUC-Oin-079316
BGIOSGA034772
IUUC-Oin-080102
BGIOSGA034767
IUUC-Oin-079552
BGIOSGA034633
IUUC-Oin-079859
BGIOSGA033639
IUUC-Oin-079417
BGIOSGA033609
IUUC-Oin-080087
BGIOSGA033003
IUUC-Oin-079281
BGIOSGA033002
IUUC-Oin-079198
BGIOSGA032987
IUUC-Oin-080187
BGIOSGA032985
IUUC-Oin-079696
BGIOSGA032984
IUUC-Oin-079825
BGIOSGA032981
IUUC-Oin-079584
BGIOSGA032976
IUUC-Oin-079731
BGIOSGA032975
IUUC-Oin-079747
BGIOSGA032974
IUUC-Oin-079608
BGIOSGA032973
IUUC-Oin-079582
BGIOSGA032972
IUUC-Oin-079523
BGIOSGA032970
IUUC-Oin-080128
BGIOSGA032963
IUUC-Oin-079492
BGIOSGA032961
IUUC-Oin-080108
BGIOSGA032960
IUUC-Oin-079664
BGIOSGA032959
IUUC-Oin-079181
BGIOSGA032957
IUUC-Oin-079924
BGIOSGA032956
IUUC-Oin-079161
BGIOSGA032955
IUUC-Oin-079831
BGIOSGA032952
IUUC-Oin-079672
BGIOSGA032950
IUUC-Oin-079618
BGIOSGA032949
IUUC-Oin-079251
BGIOSGA032948
IUUC-Oin-079208
BGIOSGA032946
IUUC-Oin-080019
BGIOSGA032945
IUUC-Oin-080027
BGIOSGA032944
IUUC-Oin-080179
BGIOSGA032943
IUUC-Oin-079108
BGIOSGA031888
IUUC-Oin-079085
BGIOSGA031883
IUUC-Oin-079860
BGIOSGA031882
IUUC-Oin-079277
BGIOSGA031880
IUUC-Oin-080093
BGIOSGA031863
IUUC-Oin-080006
BGIOSGA031862
IUUC-Oin-079053
BGIOSGA031860
IUUC-Oin-080122
BGIOSGA031857
IUUC-Oin-079591
BGIOSGA031856
IUUC-Oin-080004
BGIOSGA031855
IUUC-Oin-079472
BGIOSGA031854
IUUC-Oin-079651
BGIOSGA030541
IUUC-Oin-080015
BGIOSGA030540
IUUC-Oin-080181
BGIOSGA030343
IUUC-Oin-079299
BGIOSGA029002
IUUC-Oin-079534
BGIOSGA029001
IUUC-Oin-080205
BGIOSGA029000
IUUC-Oin-079798
BGIOSGA028227
IUUC-Oin-079531
BGIOSGA028226
IUUC-Oin-079885
BGIOSGA028224
IUUC-Oin-079512
BGIOSGA028198
IUUC-Oin-079904
BGIOSGA028195
IUUC-Oin-080168
BGIOSGA027927
IUUC-Oin-079306
BGIOSGA027926
IUUC-Oin-079913
BGIOSGA027924
IUUC-Oin-079599
BGIOSGA027808
IUUC-Oin-079870
BGIOSGA027427
IUUC-Oin-079560
BGIOSGA027425
IUUC-Oin-079421
BGIOSGA027424
IUUC-Oin-079916
BGIOSGA027423
IUUC-Oin-079466
BGIOSGA026998
IUUC-Oin-079092
BGIOSGA026997
IUUC-Oin-079570
BGIOSGA026678
IUUC-Oin-079147
BGIOSGA026651
IUUC-Oin-079828
BGIOSGA026642
IUUC-Oin-079259
BGIOSGA026641
IUUC-Oin-079052
BGIOSGA026640
IUUC-Oin-079907
BGIOSGA026636
IUUC-Oin-079197
BGIOSGA026635
IUUC-Oin-080089
BGIOSGA026633
IUUC-Oin-079577
BGIOSGA026295
IUUC-Oin-079619
BGIOSGA025477
IUUC-Oin-079401
BGIOSGA025246
IUUC-Oin-079261
BGIOSGA024760
IUUC-Oin-079803
BGIOSGA024755
IUUC-Oin-079462
BGIOSGA024160
IUUC-Oin-079506
BGIOSGA023455
IUUC-Oin-080083
BGIOSGA022792
IUUC-Oin-079650
BGIOSGA022595
IUUC-Oin-079474
BGIOSGA022594
IUUC-Oin-079353
BGIOSGA021163
IUUC-Oin-079419
BGIOSGA020714
IUUC-Oin-079260
BGIOSGA020713
IUUC-Oin-079140
BGIOSGA018255
IUUC-Oin-079880
BGIOSGA018098
IUUC-Oin-079754
BGIOSGA017287
IUUC-Oin-079156
BGIOSGA017176
IUUC-Oin-079165
BGIOSGA017175
IUUC-Oin-080182
BGIOSGA017174
IUUC-Oin-080076
BGIOSGA017169
IUUC-Oin-079637
BGIOSGA016035
IUUC-Oin-079966
BGIOSGA015787
IUUC-Oin-080090
BGIOSGA015080
IUUC-Oin-079951
BGIOSGA015077
IUUC-Oin-080051
BGIOSGA015075
IUUC-Oin-079598
BGIOSGA015074
IUUC-Oin-080140
BGIOSGA015073
IUUC-Oin-079433
BGIOSGA015070
IUUC-Oin-080190
BGIOSGA013178
IUUC-Oin-079854
BGIOSGA012410
IUUC-Oin-079812
BGIOSGA011894
IUUC-Oin-079784
BGIOSGA011425
IUUC-Oin-079440
BGIOSGA010095
IUUC-Oin-079311
BGIOSGA009092
IUUC-Oin-080148
BGIOSGA008049
IUUC-Oin-079810
BGIOSGA007919
IUUC-Oin-079498
BGIOSGA006613
IUUC-Oin-080180
BGIOSGA006612
IUUC-Oin-079542
BGIOSGA006611
IUUC-Oin-079386
BGIOSGA006218
IUUC-Oin-079187
BGIOSGA005116
IUUC-Oin-079463
BGIOSGA004522
IUUC-Oin-079668
BGIOSGA001716
IUUC-Oin-079134
BGIOSGA000112