Oryza rufipogon         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 69 genes.  Reviewed (0 or Unreviewed (69Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Oru-085062
ORUFI12G00820
A0A0E0RCT7
IUUC-Oru-085027
ORUFI11G24540
A0A0E0RC14
IUUC-Oru-084984
ORUFI11G22120
A0A0E0RB68
IUUC-Oru-084325
ORUFI11G21760
A0A0E0RB23
IUUC-Oru-084961
ORUFI11G21740
A0A0E0RB21
IUUC-Oru-084856
ORUFI11G21310
A0A0E0RAX7
IUUC-Oru-084315
ORUFI11G19430
A0A0E0RA80
IUUC-Oru-085089
ORUFI11G12230
A0A0E0R7N4
IUUC-Oru-084497
ORUFI11G02560
A0A0E0R417
IUUC-Oru-084240
ORUFI11G00700
A0A0E0R3A9
IUUC-Oru-084687
ORUFI10G11820
A0A0E0QZL4
IUUC-Oru-084468
ORUFI10G11570
A0A0E0QZI2
IUUC-Oru-084643
ORUFI10G11510
A0A0E0QZH6
IUUC-Oru-084373
ORUFI10G11500
A0A0E0QZH5
IUUC-Oru-085256
ORUFI10G11470
A0A0E0QZH2
IUUC-Oru-084551
ORUFI10G11450
A0A0E0QZH0
IUUC-Oru-084230
ORUFI10G11420
A0A0E0QZG5
IUUC-Oru-084998
ORUFI10G11410
A0A0E0QZG4
IUUC-Oru-084224
ORUFI10G11200
A0A0E0QZD3
IUUC-Oru-084968
ORUFI10G11190
A0A0E0QZD2
IUUC-Oru-084503
ORUFI10G11090
A0A0E0QZB8
IUUC-Oru-084614
ORUFI10G11040
A0A0E0QZB0
IUUC-Oru-084383
ORUFI09G06920
A0A0E0QQ09
IUUC-Oru-084218
ORUFI09G06910
A0A0E0QQ08
IUUC-Oru-085282
ORUFI09G02090
A0A0E0QNE7
IUUC-Oru-084732
ORUFI08G23450
A0A0E0QLE1
IUUC-Oru-084995
ORUFI08G23440
A0A0E0QLE0
IUUC-Oru-084374
ORUFI08G22930
A0A0E0QL77
IUUC-Oru-084823
ORUFI08G22920
A0A0E0QL76
IUUC-Oru-084187
ORUFI08G22910
A0A0E0QL75
IUUC-Oru-084693
ORUFI08G22900
A0A0E0QL74
IUUC-Oru-084636
ORUFI08G16050
A0A0E0QIT8
IUUC-Oru-084668
ORUFI08G16020
A0A0E0QIT5
IUUC-Oru-084927
ORUFI08G16010
A0A0E0QIT4
IUUC-Oru-084970
ORUFI08G12680
A0A0E0QHM9
IUUC-Oru-085271
ORUFI08G07650
A0A0E0QFW5
IUUC-Oru-084286
ORUFI08G07560
A0A0E0QFV7
IUUC-Oru-084526
ORUFI08G07550
A0A0E0QFV6
IUUC-Oru-084484
ORUFI08G07460
A0A0E0QFU6
IUUC-Oru-084321
ORUFI08G06330
A0A0E0QFG3
IUUC-Oru-085273
ORUFI08G00320
A0A0E0QDA9
IUUC-Oru-084762
ORUFI07G25720
A0A0E0QC43
IUUC-Oru-084466
ORUFI07G09430
G8JBH2
5
IUUC-Oru-084909
ORUFI07G04760
A0A0E0Q4S1
IUUC-Oru-084278
ORUFI07G04060
A0A0E0Q4I8
IUUC-Oru-084765
ORUFI07G03870
A0A0E0Q4G3
IUUC-Oru-085118
ORUFI06G26390
A0A0E0Q1J2
IUUC-Oru-084188
ORUFI06G25950
A0A0E0Q1E0
IUUC-Oru-084399
ORUFI06G17340
A0A0E0PYF4
IUUC-Oru-085228
ORUFI06G13380
A0A0E0PX20
IUUC-Oru-084746
ORUFI05G24550
A0A0E0PQ32
IUUC-Oru-084457
ORUFI05G24530
A0A0E0PQ30
IUUC-Oru-084260
ORUFI05G16760
A0A0E0PM67
IUUC-Oru-085081
ORUFI05G13500
A0A0E0PL14
IUUC-Oru-084209
ORUFI04G29880
A0A0E0PF59
IUUC-Oru-084331
ORUFI04G02660
A0A0E0P560
IUUC-Oru-085217
ORUFI03G31230
A0A0E0NZQ4
IUUC-Oru-084408
ORUFI03G29880
A0A0E0NZ91
IUUC-Oru-084626
ORUFI03G14390
A0A0E0NTR5
IUUC-Oru-085017
ORUFI03G03970
A0A0E0NPW5
IUUC-Oru-084262
ORUFI02G34930
A0A0E0NL91
IUUC-Oru-084799
ORUFI02G22190
A0A0E0NGL7
IUUC-Oru-084227
ORUFI02G14020
A0A0E0NDM9
IUUC-Oru-084261
ORUFI02G14000
A0A0E0NDM7
IUUC-Oru-084802
ORUFI02G13980
A0A0E0NDM5
IUUC-Oru-084384
ORUFI02G11310
A0A0E0NCN6
IUUC-Oru-084680
ORUFI01G47340
A0A0E0N7M3
IUUC-Oru-084212
ORUFI01G46370
A0A0E0N787
IUUC-Oru-084496
ORUFI01G35500
A0A0E0N2Z0