Papio anubis         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 90 genes.  Reviewed (0 or Unreviewed (90Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Pan-092327
ENSPANG00000018211.2
A0A096NJU9
KCTD17
IUUC-Pan-092592
ENSPANG00000016037.1
A0A096NJG6
BTBD7
IUUC-Pan-092388
ENSPANG00000026123.1
A0A096NRT7
NACC2
IUUC-Pan-092612
ENSPANG00000026401.1
A0A096NU71
KCTD6
IUUC-Pan-092572
ENSPANG00000008922.1
A0A096N3K8
ZBTB47
IUUC-Pan-092106
ENSPANG00000020199.1
A0A096NST3
KCTD2
IUUC-Pan-091850
ENSPANG00000015251.1
A0A096N759
ZBTB33
IUUC-Pan-091696
ENSPANG00000007019.1
A0A096NHI1
ZBTB22
IUUC-Pan-092047
ENSPANG00000012861.1
A0A096N752
KCTD21
IUUC-Pan-092536
ENSPANG00000000728.1
A0A096NIV8
ZBTB21
IUUC-Pan-091982
ENSPANG00000017504.1
A0A096NS75
LZTR1
IUUC-Pan-091916
ENSPANG00000024819.1
A0A096P214
ZBTB34
IUUC-Pan-092574
ENSPANG00000026081.1
A0A096N2E1
MYNN
IUUC-Pan-092110
ENSPANG00000024354.1
A0A096P2F4
ANKFY1
IUUC-Pan-092044
ENSPANG00000003128.1
A0A096NUA3
ZBTB14
IUUC-Pan-092429
ENSPANG00000016510.2
A0A096MW42
IUUC-Pan-092607
ENSPANG00000016356.1
A0A096NMK1
KCTD13
IUUC-Pan-092651
ENSPANG00000024201.1
A0A096P2M1
BCL6B
IUUC-Pan-092409
ENSPANG00000024098.1
A0A096P2Q4
ZBTB4
IUUC-Pan-092323
ENSPANG00000020643.2
A0A096NN05
BTBD1
IUUC-Pan-092567
ENSPANG00000015665.1
A0A096NZE5
ZBTB49
IUUC-Pan-092359
ENSPANG00000023921.2
A0A0A0MVQ7
KLHL26
IUUC-Pan-092880
ENSPANG00000023530.1
A0A096P384
TNFAIP1
IUUC-Pan-091888
ENSPANG00000015972.1
A0A096N2Z6
ZBTB17
IUUC-Pan-092425
ENSPANG00000008469.1
A0A096MPD9
ZBTB3
IUUC-Pan-092185
ENSPANG00000017177.1
A0A096NF64
RCBTB2
IUUC-Pan-092337
ENSPANG00000010574.1
A0A0A0MXB9
ZBTB7A
IUUC-Pan-092530
ENSPANG00000021173.2
A0A096NQF9
ZBTB48
IUUC-Pan-092647
ENSPANG00000001078.1
A0A096NPH1
KLHL36
IUUC-Pan-092041
ENSPANG00000005906.1
A0A096NN35
KLHL25
IUUC-Pan-091889
ENSPANG00000018749.1
A0A096MTP3
ZBTB40
IUUC-Pan-092553
ENSPANG00000011709.1
A0A096N3H8
ZBTB7B
IUUC-Pan-092829
ENSPANG00000000863.1
A0A096NL70
KCTD5
IUUC-Pan-092824
ENSPANG00000006968.1
A0A096NHW7
BTBD9
IUUC-Pan-092903
ENSPANG00000016323.1
A0A096MNZ0
ZBTB6
IUUC-Pan-092557
ENSPANG00000016793.1
A0A096N160
IBTK
IUUC-Pan-092489
ENSPANG00000020434.1
A0A096MXP8
RHOBTB2
IUUC-Pan-092642
ENSPANG00000014883.1
A0A096ML61
KBTBD3
IUUC-Pan-091805
ENSPANG00000005758.1
A0A096NJA2
KLHL31
IUUC-Pan-092921
ENSPANG00000022340.1
A0A096NE31
KLHL29
IUUC-Pan-091848
ENSPANG00000021934.1
A0A096MXN0
ZBTB18
IUUC-Pan-092780
ENSPANG00000017419.1
A0A096NVS5
GZF1
IUUC-Pan-091830
ENSPANG00000011134.1
A0A096MMF5
ZNF131
IUUC-Pan-092149
ENSPANG00000004047.1
A0A096MXR8
KCTD10
IUUC-Pan-092916
ENSPANG00000009340.1
A0A096NCY1
IUUC-Pan-092721
ENSPANG00000024108.1
A0A096NK33
ZBTB42
IUUC-Pan-092556
ENSPANG00000012823.1
A0A096N5X6
ZBTB9
IUUC-Pan-092912
ENSPANG00000010839.1
A0A0A0MU74
ZBTB45
IUUC-Pan-092700
ENSPANG00000012545.1
A0A096N3S7
ZBTB41
IUUC-Pan-091730
ENSPANG00000008097.1
A0A0A0MWL5
SHKBP1
IUUC-Pan-092718
ENSPANG00000013400.1
A0A096MW19
KLHL14
IUUC-Pan-092324
ENSPANG00000017677.2
A0A096NNY3
BCL6
IUUC-Pan-092161
ENSPANG00000006918.1
A0A096NZ01
ZBTB24
IUUC-Pan-091977
ENSPANG00000010573.1
A0A096MSC1
KLHL15
IUUC-Pan-092655
ENSPANG00000004447.1
A0A0A0MUH9
NACC1
IUUC-Pan-091890
ENSPANG00000015046.1
A0A096N4G4
ABTB2
IUUC-Pan-092508
ENSPANG00000012378.1
A0A096MR10
BTBD18
IUUC-Pan-092040
ENSPANG00000017205.1
A0A096MP04
KBTBD4
IUUC-Pan-092894
ENSPANG00000021760.1
A0A096NK55
BTBD6
IUUC-Pan-092028
ENSPANG00000019096.1
A0A096MYX6
ZBTB8A
IUUC-Pan-091894
ENSPANG00000005795.1
A0A096NPJ9
BTBD11
IUUC-Pan-092637
ENSPANG00000020967.1
A0A096NVJ0
BTBD3
IUUC-Pan-092131
ENSPANG00000013569.1
A0A096MMS2
RHOBTB3
IUUC-Pan-091711
ENSPANG00000017978.1
A0A096N4B1
ZBTB44
IUUC-Pan-092136
ENSPANG00000019916.1
A0A096NVK9
ZBTB25
IUUC-Pan-092450
ENSPANG00000026190.1
A0A096NN45
ZBTB46
IUUC-Pan-091864
ENSPANG00000007995.1
A0A096NQH3
GMCL1
IUUC-Pan-092109
ENSPANG00000000295.1
A0A096MZA6
ZBTB43
IUUC-Pan-092818
ENSPANG00000006007.1
A0A096MM29
BTBD19
IUUC-Pan-091803
ENSPANG00000007661.2
A0A096P0B5
BACH1
IUUC-Pan-091713
ENSPANG00000024439.1
A0A096NDA8
KBTBD8
IUUC-Pan-092670
ENSPANG00000024676.1
A0A0A0MWD2
BTBD2
IUUC-Pan-092304
ENSPANG00000024390.1
A0A096MNR5
KLHL32
IUUC-Pan-092811
ENSPANG00000002385.1
A0A096N9M3
ZBTB37
IUUC-Pan-092901
ENSPANG00000024301.1
A0A096NS86
HIC2
IUUC-Pan-092775
ENSPANG00000021636.1
A0A096MQ31
ZBTB11
IUUC-Pan-091983
ENSPANG00000022029.1
A0A096P560
RHOBTB1
IUUC-Pan-092610
ENSPANG00000012353.1
A0A096NB55
KLHL34
IUUC-Pan-092878
ENSPANG00000013363.1
A0A096MT46
BTBD8
IUUC-Pan-092414
ENSPANG00000016718.1
A0A096MRS0
KCTD3
IUUC-Pan-092309
ENSPANG00000016942.1
A0A096NDG9
ZBTB7C
IUUC-Pan-092159
ENSPANG00000006817.1
A0A096NRN0
BACH2
IUUC-Pan-091854
ENSPANG00000012176.1
A0A096NAF5
ZBTB39
IUUC-Pan-091689
ENSPANG00000018989.1
A0A096MMQ9
ZBTB38
IUUC-Pan-092729
ENSPANG00000008194.1
A0A096N0N4
KLHL30
IUUC-Pan-092563
ENSPANG00000005924.1
A0A096NC14
ZBTB16
IUUC-Pan-092221
ENSPANG00000015935.1
A0A096N592
ZBTB20
IUUC-Pan-092522
ENSPANG00000007309.1
A0A096N366
KBTBD13
IUUC-Pan-092758
ENSPANG00000020391.1
A0A096MUA1
ABTB1
IUUC-Pan-092753
ENSPANG00000016770.1
A0A096N133
IVNS1ABP