Phaeosphaeria nodorum         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 17 genes.  Reviewed (0 or Unreviewed (17Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Pno-095029
SNOG_15794
Q0TXP0
SNOG_15794
IUUC-Pno-094860
SNOG_15476
Q0TYD5
SNOG_15476
IUUC-Pno-094888
SNOG_14849
Q0TZZ6
SNOG_14849
IUUC-Pno-095092
SNOG_14203
Q0U233
SNOG_14203
IUUC-Pno-095011
SNOG_12681
Q0U6D3
SNOG_12681
IUUC-Pno-094921
SNOG_12378
Q0U786
SNOG_12378
IUUC-Pno-094901
SNOG_12159
Q0U7V5
SNOG_12159
IUUC-Pno-095007
SNOG_11607
Q0U9F7
SNOG_11607
IUUC-Pno-094976
SNOG_10366
Q0UCZ8
SNOG_10366
IUUC-Pno-094928
SNOG_08302
Q0UIW2
SNOG_08302
IUUC-Pno-094959
SNOG_07430
Q0ULD4
SNOG_07430
IUUC-Pno-094989
SNOG_06199
Q0UPW5
SNOG_06199
IUUC-Pno-095006
SNOG_05231
Q0USN3
SNOG_05231
IUUC-Pno-095090
SNOG_05128
Q0USY6
SNOG_05128
IUUC-Pno-094910
SNOG_04956
Q0UTF8
SNOG_04956
IUUC-Pno-094945
SNOG_02942
Q0UZ72
SNOG_02942
IUUC-Pno-094863
SNOG_01999
Q0V1W5
SNOG_01999