Sarcophilus harrisii         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 77 genes.  Reviewed (0 or Unreviewed (77Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Sha-107047
ENSSHAG00000018698.1
G3X338
KCTD2
IUUC-Sha-107580
ENSSHAG00000018501.1
G3X2E6
KCTD21
IUUC-Sha-107367
ENSSHAG00000018016.1
G3X0Q1
KBTBD11
IUUC-Sha-107421
ENSSHAG00000017693.1
G3WZK7
ZBTB38
IUUC-Sha-107445
ENSSHAG00000017616.1
G3WZB4
ZBTB46
IUUC-Sha-106994
ENSSHAG00000017310.1
G3WYA3
KLHL31
IUUC-Sha-107644
ENSSHAG00000016863.1
G3WWR2
RHOBTB1
IUUC-Sha-107158
ENSSHAG00000016625.1
G3WVX5
KLHL32
IUUC-Sha-107020
ENSSHAG00000016594.1
G3WVT5
ZBTB10
IUUC-Sha-107171
ENSSHAG00000016295.1
G3WUT6
BACH2
IUUC-Sha-107241
ENSSHAG00000015981.1
G3WTS5
ZBTB5
IUUC-Sha-106671
ENSSHAG00000015851.1
G3WTB7
BTBD18
IUUC-Sha-107271
ENSSHAG00000015679.1
G3WSR2
BTBD11
IUUC-Sha-106799
ENSSHAG00000014880.1
G3WQ09
ZBTB40
IUUC-Sha-106826
ENSSHAG00000014427.1
G3WNG3
GMCL1
IUUC-Sha-107275
ENSSHAG00000014296.1
G3WN00
NACC1
IUUC-Sha-107259
ENSSHAG00000013935.1
G3WLS1
BCL6
IUUC-Sha-107012
ENSSHAG00000013931.1
G3WLR5
ZBTB7C
IUUC-Sha-107076
ENSSHAG00000013842.1
G3WLG0
RCBTB2
IUUC-Sha-107545
ENSSHAG00000013600.1
G3WKL9
NACC2
IUUC-Sha-107452
ENSSHAG00000013098.1
G3WIW3
KBTBD12
IUUC-Sha-106775
ENSSHAG00000013043.1
G3WIP3
ZBTB2
IUUC-Sha-107242
ENSSHAG00000012986.1
G3WIH4
KLHL34
IUUC-Sha-106996
ENSSHAG00000012552.1
G3WH00
TNFAIP1
IUUC-Sha-107516
ENSSHAG00000012399.1
G3WGG8
ZBTB34
IUUC-Sha-107095
ENSSHAG00000011642.1
G3WDW9
ABTB1
IUUC-Sha-107212
ENSSHAG00000011534.1
G3WDI9
ZNF131
IUUC-Sha-106797
ENSSHAG00000011492.1
G3WDD8
IBTK
IUUC-Sha-107257
ENSSHAG00000011410.1
G3WD39
KCTD10
IUUC-Sha-107053
ENSSHAG00000011233.1
G3WCI6
BTBD19
IUUC-Sha-106488
ENSSHAG00000011152.1
G3WC83
KIAA1107
IUUC-Sha-106719
ENSSHAG00000010962.1
G3WBK7
KLHL35
IUUC-Sha-106830
ENSSHAG00000010644.1
G3WAH4
RHOBTB3
IUUC-Sha-107306
ENSSHAG00000010423.1
G3W9R0
ZBTB8A
IUUC-Sha-107436
ENSSHAG00000010210.1
G3W8Z3
IVNS1ABP
IUUC-Sha-106613
ENSSHAG00000010188.1
G3W8W4
ZBTB1
IUUC-Sha-107042
ENSSHAG00000010038.1
G3W8D3
KCTD13
IUUC-Sha-107295
ENSSHAG00000009882.1
G3W7U0
ZBTB16
IUUC-Sha-107219
ENSSHAG00000009872.1
G3W7S9
ZBTB25
IUUC-Sha-107147
ENSSHAG00000009770.1
G3W7F4
ZBTB33
IUUC-Sha-106646
ENSSHAG00000009719.1
G3W796
ZBTB20
IUUC-Sha-107347
ENSSHAG00000009614.1
G3W6W6
ZBTB44
IUUC-Sha-106957
ENSSHAG00000009367.1
G3W611
GZF1
IUUC-Sha-106743
ENSSHAG00000009045.1
G3W4X3
KCTD6
IUUC-Sha-107596
ENSSHAG00000008804.1
G3W434
ZBTB7A
IUUC-Sha-106850
ENSSHAG00000008659.1
G3W3K4
ZBTB18
IUUC-Sha-107345
ENSSHAG00000008534.1
G3W349
ZBTB42
IUUC-Sha-107166
ENSSHAG00000008414.1
G3W2R8
ZBTB49
IUUC-Sha-106757
ENSSHAG00000008340.1
G3W2I5
ZBTB11
IUUC-Sha-107619
ENSSHAG00000008083.1
G3W1P0
KLHL26
IUUC-Sha-106521
ENSSHAG00000007725.1
G3W0G5
KLHL15
IUUC-Sha-106960
ENSSHAG00000007698.1
G3W0D6
ZBTB47
IUUC-Sha-106657
ENSSHAG00000007426.1
G3VZG8
ZBTB22
IUUC-Sha-106477
ENSSHAG00000007242.1
G3VYV4
BTBD2
IUUC-Sha-107605
ENSSHAG00000007236.1
G3VYU8
ZBTB48
IUUC-Sha-106813
ENSSHAG00000007165.1
G3VYL6
CCIN
IUUC-Sha-107477
ENSSHAG00000006755.1
G3VX77
ZBTB37
IUUC-Sha-107059
ENSSHAG00000006419.1
G3VW29
BACH1
IUUC-Sha-107503
ENSSHAG00000006203.1
G3VVD5
ZBTB14
IUUC-Sha-107322
ENSSHAG00000005855.1
G3VU78
KLHL4
IUUC-Sha-106785
ENSSHAG00000005853.1
G3VU74
BTBD9
IUUC-Sha-107232
ENSSHAG00000005160.1
G3VRW2
ZBTB7B
IUUC-Sha-107381
ENSSHAG00000005024.1
G3VRE7
KLHL36
IUUC-Sha-106718
ENSSHAG00000005014.1
G3VRD7
ZBTB41
IUUC-Sha-107460
ENSSHAG00000004679.1
G3VQ99
ZBTB17
IUUC-Sha-106737
ENSSHAG00000004674.1
G3VQ94
BTBD7
IUUC-Sha-107135
ENSSHAG00000004614.1
G3VQ20
ZBTB39
IUUC-Sha-107182
ENSSHAG00000004592.1
G3VPZ4
BTBD6
IUUC-Sha-107037
ENSSHAG00000004178.1
G3VNK3
IUUC-Sha-106756
ENSSHAG00000003998.1
G3VMY9
ZBTB4
IUUC-Sha-107110
ENSSHAG00000003625.1
G3VLQ6
ZBTB24
IUUC-Sha-107317
ENSSHAG00000003399.1
G3VL05
RHOBTB2
IUUC-Sha-106817
ENSSHAG00000003001.1
G3VJQ7
KLHL22
IUUC-Sha-107002
ENSSHAG00000002217.1
G3VH50
ZBTB21
IUUC-Sha-107462
ENSSHAG00000002126.1
G3VGU4
IUUC-Sha-106685
ENSSHAG00000000607.1
G3VBX4
IUUC-Sha-107591
ENSSHAG00000000166.1
G3VAJ4
BCL6B