Trichoderma reesei         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 10 genes.  Reviewed (0 or Unreviewed (10Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Tre-122227
TRIREDRAFT_102952
G0R8R3
TRIREDRAFT_102952
IUUC-Tre-122160
TRIREDRAFT_102947
G0R8Q8
TRIREDRAFT_102947
IUUC-Tre-122091
TRIREDRAFT_54511
G0R8S6
TRIREDRAFT_54511
IUUC-Tre-121919
TRIREDRAFT_61967
G0RJK3
TRIREDRAFT_61967
IUUC-Tre-121903
TRIREDRAFT_122069
G0RKD2
TRIREDRAFT_122069
IUUC-Tre-122129
TRIREDRAFT_107780
G0RKA6
TRIREDRAFT_107780
IUUC-Tre-122094
TRIREDRAFT_65214
G0RPE9
TRIREDRAFT_65214
IUUC-Tre-122111
TRIREDRAFT_67647
G0RSW7
TRIREDRAFT_67647
IUUC-Tre-121929
TRIREDRAFT_51558
G0RTJ7
TRIREDRAFT_51558
IUUC-Tre-122202
TRIREDRAFT_124104
G0RWF4
TRIREDRAFT_124104