Trichoderma virens         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 12 genes.  Reviewed (0 or Unreviewed (12Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Tvi-122612
TRIVIDRAFT_175713
G9MEX8
TRIVIDRAFT_175713
IUUC-Tvi-122274
TRIVIDRAFT_62054
G9MIP8
TRIVIDRAFT_62054
IUUC-Tvi-122498
TRIVIDRAFT_54366
G9MLQ3
TRIVIDRAFT_54366
IUUC-Tvi-122551
TRIVIDRAFT_30335
G9MLP7
TRIVIDRAFT_30335
IUUC-Tvi-122399
TRIVIDRAFT_229793
G9MLN2
TRIVIDRAFT_229793
IUUC-Tvi-122439
TRIVIDRAFT_63891
G9MP89
TRIVIDRAFT_63891
IUUC-Tvi-122536
TRIVIDRAFT_191105
G9MT25
TRIVIDRAFT_191105
IUUC-Tvi-122406
TRIVIDRAFT_137223
G9N2B3
TRIVIDRAFT_137223
IUUC-Tvi-122419
TRIVIDRAFT_225068
G9N284
TRIVIDRAFT_225068
IUUC-Tvi-122627
TRIVIDRAFT_44225
G9N3R2
TRIVIDRAFT_44225
IUUC-Tvi-122444
TRIVIDRAFT_39063
G9NDK5
TRIVIDRAFT_39063
IUUC-Tvi-122427
TRIVIDRAFT_37976
G9NCS2
TRIVIDRAFT_37976