Tursiops truncatus         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 82 genes.  Reviewed (0 or Unreviewed (82Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Ttr-129204
ENSTTRG00000017230.1
BCL6
IUUC-Ttr-128844
ENSTTRG00000017109.1
ABTB1
IUUC-Ttr-128317
ENSTTRG00000016987.1
SLX4
IUUC-Ttr-128586
ENSTTRG00000016956.1
ZBTB6
IUUC-Ttr-129052
ENSTTRG00000016282.1
CCIN
IUUC-Ttr-128334
ENSTTRG00000015738.1
RHOBTB3
IUUC-Ttr-128620
ENSTTRG00000015707.1
ZBTB17
IUUC-Ttr-129129
ENSTTRG00000014967.1
ZBTB8A
IUUC-Ttr-128516
ENSTTRG00000014409.1
BTBD8
IUUC-Ttr-129080
ENSTTRG00000014262.1
ZBTB4
IUUC-Ttr-128395
ENSTTRG00000014190.1
ZBTB2
IUUC-Ttr-128803
ENSTTRG00000014159.1
KBTBD4
IUUC-Ttr-129245
ENSTTRG00000013750.1
KCTD6
IUUC-Ttr-128485
ENSTTRG00000013046.1
ZBTB39
IUUC-Ttr-128785
ENSTTRG00000012820.1
ZBTB49
IUUC-Ttr-128382
ENSTTRG00000012756.1
RHOBTB2
IUUC-Ttr-128865
ENSTTRG00000012644.1
ZBTB21
IUUC-Ttr-129214
ENSTTRG00000012468.1
KLHL15
IUUC-Ttr-128681
ENSTTRG00000012229.1
ZBTB46
IUUC-Ttr-128460
ENSTTRG00000012208.1
IPP
IUUC-Ttr-128377
ENSTTRG00000012016.1
KBTBD8
IUUC-Ttr-128572
ENSTTRG00000012000.1
KLHL36
IUUC-Ttr-128944
ENSTTRG00000011636.1
ZBTB7C
IUUC-Ttr-128912
ENSTTRG00000011600.1
BTBD7
IUUC-Ttr-128408
ENSTTRG00000011546.1
IUUC-Ttr-128900
ENSTTRG00000011404.1
KBTBD11
IUUC-Ttr-129220
ENSTTRG00000011354.1
KLHL4
IUUC-Ttr-128440
ENSTTRG00000011345.1
GZF1
IUUC-Ttr-128412
ENSTTRG00000010920.1
KLHL32
IUUC-Ttr-128222
ENSTTRG00000010497.1
KLHL26
IUUC-Ttr-128322
ENSTTRG00000010441.1
ZBTB44
IUUC-Ttr-128276
ENSTTRG00000010279.1
PATZ1
IUUC-Ttr-129110
ENSTTRG00000010141.1
TNFAIP1
IUUC-Ttr-129202
ENSTTRG00000010087.1
F4YE69
KLHL30; KBTBD3
IUUC-Ttr-128183
ENSTTRG00000009789.1
KCTD11
IUUC-Ttr-129151
ENSTTRG00000009725.1
ZBTB47
IUUC-Ttr-128199
ENSTTRG00000009644.1
ZNF131
IUUC-Ttr-129088
ENSTTRG00000009614.1
ZBTB43
IUUC-Ttr-128627
ENSTTRG00000009610.1
ZBTB34
IUUC-Ttr-128603
ENSTTRG00000009336.1
KCTD3
IUUC-Ttr-128653
ENSTTRG00000009176.1
LZTR1
IUUC-Ttr-128971
ENSTTRG00000008689.1
ZBTB41
IUUC-Ttr-128668
ENSTTRG00000008564.1
ZBTB37
IUUC-Ttr-128206
ENSTTRG00000008293.1
ZBTB5
IUUC-Ttr-129255
ENSTTRG00000008237.1
KCTD5
IUUC-Ttr-129275
ENSTTRG00000007839.1
KLHL33
IUUC-Ttr-128513
ENSTTRG00000007764.1
ABTB2
IUUC-Ttr-128618
ENSTTRG00000007494.1
KLHL14
IUUC-Ttr-128197
ENSTTRG00000007493.1
GMCL1
IUUC-Ttr-128369
ENSTTRG00000007427.1
NACC2
IUUC-Ttr-129180
ENSTTRG00000007161.1
SHKBP1
IUUC-Ttr-129023
ENSTTRG00000006932.1
ZBTB9
IUUC-Ttr-128563
ENSTTRG00000006780.1
ZBTB7A
IUUC-Ttr-128417
ENSTTRG00000006598.1
F2VR87
BTBD6; BTBD3
IUUC-Ttr-128342
ENSTTRG00000006384.1
NACC1
IUUC-Ttr-129274
ENSTTRG00000006342.1
ZBTB48
IUUC-Ttr-128168
ENSTTRG00000006126.1
KCTD21
IUUC-Ttr-128664
ENSTTRG00000006088.1
IBTK
IUUC-Ttr-128624
ENSTTRG00000005929.1
IVNS1ABP
IUUC-Ttr-128588
ENSTTRG00000005501.1
KCTD13
IUUC-Ttr-128538
ENSTTRG00000005023.1
ZBTB33
IUUC-Ttr-129203
ENSTTRG00000004311.1
ZBTB22
IUUC-Ttr-128575
ENSTTRG00000004261.1
RCBTB2
IUUC-Ttr-129257
ENSTTRG00000004185.1
ZBTB24
IUUC-Ttr-128316
ENSTTRG00000003982.1
BCL6B
IUUC-Ttr-128874
ENSTTRG00000003941.1
BACH2
IUUC-Ttr-128733
ENSTTRG00000003694.1
IUUC-Ttr-128430
ENSTTRG00000003376.1
KBTBD3
IUUC-Ttr-129007
ENSTTRG00000002849.1
ZBTB11
IUUC-Ttr-128872
ENSTTRG00000002495.1
ZBTB40
IUUC-Ttr-128321
ENSTTRG00000002477.1
ZBTB3
IUUC-Ttr-129302
ENSTTRG00000001884.1
MYNN
IUUC-Ttr-128285
ENSTTRG00000001510.1
ZBTB16
IUUC-Ttr-128632
ENSTTRG00000001092.1
KCTD17
IUUC-Ttr-129079
ENSTTRG00000001086.1
RHOBTB1
IUUC-Ttr-128343
ENSTTRG00000000904.1
KLHL18
IUUC-Ttr-128994
ENSTTRG00000000741.1
KLHL31
IUUC-Ttr-128805
ENSTTRG00000000721.1
BACH1
IUUC-Ttr-128943
ENSTTRG00000000615.1
IUUC-Ttr-128357
ENSTTRG00000000531.1
ZBTB1
IUUC-Ttr-128226
ENSTTRG00000000529.1
ZBTB25
IUUC-Ttr-129304
ENSTTRG00000000396.2
BTBD9