Yarrowia lipolytica         E3 adaptor/Cullin RING/BCR/BTB_Other


※ E3 adaptor/Cullin RING/BCR/BTB_Other family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_Other family as the proteins contain only BTB domain but not 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID:16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 10 genes.  Reviewed (0 or Unreviewed (10Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Yli-134678
YALI0_A11759g
Q6CH72
YALI0_A11759g
IUUC-Yli-134409
YALI0_A09537g
Q6CHF4
YALI0_A09537g
IUUC-Yli-134483
YALI0_A03201g
Q6CHZ1
YALI0_A03201g
IUUC-Yli-134612
YALI0_A01650g
Q6CI51
YALI0_A01650g
IUUC-Yli-134351
YALI0_B19228g
Q6CE21
YALI0_B19228g
IUUC-Yli-134494
YALI0_C22506g
Q6CB22
YALI0_C22506g
IUUC-Yli-134535
YALI0_C01925g
Q6CDB7
YALI0_C01925g
IUUC-Yli-134458
YALI0_D21406g
Q6C8A2
YALI0_D21406g
IUUC-Yli-134395
YALI0_D10087g
Q6C9L8
YALI0_D10087g
IUUC-Yli-134597
YALI0_E07293g
Q6C6Q3
YALI0_E07293g