Colletotrichum gloeosporioides         E3 adaptor/Cullin RING/Cullin


※ E3 adaptor/Cullin RING/Cullin family introduction

    Cullin family are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases. Cullin consists of several domains, including cullin repeat domain, a 4-helical bundle domain, an alpha+beta domain, and a winged helix-like domain. Members of Cullin family are found throughout eukaryotes. Humans express seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), each forming part of a multi-subunit ubiquitin complex. Cullin RING ubiquitin ligases (CRLs), such as Cul1 (SCF), play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology domain binds the RING protein. The RING protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin-homology domain, such as the APC2 subunit of the anaphase-promoting complex/cyclosome and the p53 cytoplasmic anchor PARC; both APC2 and PARC have ubiquitin ligase activity. The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins (1).

1. http://www.ebi.ac.uk/interpro/entry/IPR001373




There are 4 genes.  Reviewed (0 or Unreviewed (4Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Cgl-026630
CGGC5_4620
L2GC00
CGGC5_4620
IUUC-Cgl-026442
CGGC5_6424
L2G5K9
CGGC5_6424
IUUC-Cgl-026761
CGGC5_7833
L2G034
CGGC5_7833
IUUC-Cgl-026452
CGGC5_2081
L2FF55
CGGC5_2081