Pongo abelii         E3 adaptor/Cullin RING/Cullin


※ E3 adaptor/Cullin RING/Cullin family introduction

    Cullin family are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases. Cullin consists of several domains, including cullin repeat domain, a 4-helical bundle domain, an alpha+beta domain, and a winged helix-like domain. Members of Cullin family are found throughout eukaryotes. Humans express seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), each forming part of a multi-subunit ubiquitin complex. Cullin RING ubiquitin ligases (CRLs), such as Cul1 (SCF), play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology domain binds the RING protein. The RING protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin-homology domain, such as the APC2 subunit of the anaphase-promoting complex/cyclosome and the p53 cytoplasmic anchor PARC; both APC2 and PARC have ubiquitin ligase activity. The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins (1).

1. http://www.ebi.ac.uk/interpro/entry/IPR001373




There are 9 genes.  Reviewed (0 or Unreviewed (9Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Pab-097816
ENSPPYG00000020686.2
H2PWN2
CUL4B
IUUC-Pab-097544
ENSPPYG00000019905.2
Q5RCF3
CUL2
IUUC-Pab-097600
ENSPPYG00000019812.2
H2PU30
ANAPC2
IUUC-Pab-097578
ENSPPYG00000018146.2
Q5R4G6
CUL1
IUUC-Pab-098635
ENSPPYG00000016634.2
H2PJ48
CUL9
IUUC-Pab-098383
ENSPPYG00000016629.2
H2PJ39
CUL7
IUUC-Pab-098164
ENSPPYG00000013231.2
H2P8S3
CUL3
IUUC-Pab-097622
ENSPPYG00000005523.2
H2NKD8
CUL4A
IUUC-Pab-098248
ENSPPYG00000003842.2
H2NF69
CUL5