Sorex araneus         E3 adaptor/Cullin RING/Cullin


※ E3 adaptor/Cullin RING/Cullin family introduction

    Cullin family are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases. Cullin consists of several domains, including cullin repeat domain, a 4-helical bundle domain, an alpha+beta domain, and a winged helix-like domain. Members of Cullin family are found throughout eukaryotes. Humans express seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), each forming part of a multi-subunit ubiquitin complex. Cullin RING ubiquitin ligases (CRLs), such as Cul1 (SCF), play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology domain binds the RING protein. The RING protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin-homology domain, such as the APC2 subunit of the anaphase-promoting complex/cyclosome and the p53 cytoplasmic anchor PARC; both APC2 and PARC have ubiquitin ligase activity. The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins (1).

1. http://www.ebi.ac.uk/interpro/entry/IPR001373




There are 7 genes.  Reviewed (0 or Unreviewed (7Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Sar-113138
ENSSARG00000012982.1
CUL2
IUUC-Sar-113144
ENSSARG00000009999.1
CUL3
IUUC-Sar-112956
ENSSARG00000007838.1
B3EX44
CUL4A
IUUC-Sar-113132
ENSSARG00000003443.1
CUL9
IUUC-Sar-113581
ENSSARG00000001760.1
CUL4B
IUUC-Sar-113750
ENSSARG00000000883.1
CUL7
IUUC-Sar-113558
ENSSARG00000000456.1
CUL5