DWD represents "DDB1-binding WD40 protein", a 16-residue motif as the subdomain of WD40 repeats (1). Members of DWD family can directly bind to the DDB1 and serve as the substrate recognition subunits of the DCX (DDB1-CUL4-X-box) E3 ligase complex, which display important functions in eukaryotic biology and in human diseases (2).

1. Jackson, S. and Xiong, Y. (2009). CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem. Sci., 34, 562-570. PMID: 19818632

2. Angers, S., Li, T., Yi, X., MacCoss, M.J., Moon, R.T. and Zheng, N. (2006). Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature, 443, 590-593. PMID: 16964240