Callithrix jacchus         E3 adaptor/Cullin RING/BCR/BTB_3-box


※ E3 adaptor/Cullin RING/BCR/BTB_3-box family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_3-box family as the proteins contain both BTB domain and 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID: 16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 35 genes.  Reviewed (0 or Unreviewed (35Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Cja-019582
ENSCJAG00000006231.2
F7D300
KLHL12
IUUC-Cja-018938
ENSCJAG00000021216.2
F7DUL3
KLHL24
IUUC-Cja-019119
ENSCJAG00000009306.2
F7FYX2
KLHL20
IUUC-Cja-019774
ENSCJAG00000017761.2
F6YD80
KBTBD7
IUUC-Cja-018839
ENSCJAG00000021976.2
F7HBP4
KLHL25
IUUC-Cja-018888
ENSCJAG00000021212.2
F7E903
KLHL6
IUUC-Cja-019795
ENSCJAG00000037032.1
F6QF90
KLHL40
IUUC-Cja-018915
ENSCJAG00000017764.2
F7GJB7
KBTBD6
IUUC-Cja-019494
ENSCJAG00000016663.2
F7ANZ0
ENC1
IUUC-Cja-019865
ENSCJAG00000016571.2
F6YPB4
GAN
IUUC-Cja-019103
ENSCJAG00000016532.2
F7A7K5
KLHL1
IUUC-Cja-019752
ENSCJAG00000016358.2
H9KX74
KLHL22
IUUC-Cja-019878
ENSCJAG00000016063.2
F7I7N3
KLHL28
IUUC-Cja-019924
ENSCJAG00000015068.1
F7HEX1
KLHL11
IUUC-Cja-018771
ENSCJAG00000013788.2
F6YZQ4
IPP
IUUC-Cja-019227
ENSCJAG00000012133.1
F7BCH0
SPOPL
IUUC-Cja-018916
ENSCJAG00000010479.2
F6TEK5
KLHL4
IUUC-Cja-018942
ENSCJAG00000009218.3
F7HYP2
KLHL2
IUUC-Cja-019947
ENSCJAG00000009166.2
F6YK77
KBTBD2
IUUC-Cja-019520
ENSCJAG00000008772.2
F6ZPR4
RCBTB1
IUUC-Cja-019495
ENSCJAG00000007588.3
F7IIZ9
KLHL29
IUUC-Cja-019981
ENSCJAG00000007104.2
F6WLU9
SPOP
IUUC-Cja-018886
ENSCJAG00000006681.3
F7H8G6
KLHL23; PHOSPHO2-KLHL23
IUUC-Cja-018823
ENSCJAG00000006677.2
F7HDW0
KEAP1
IUUC-Cja-019348
ENSCJAG00000006532.2
F7EJJ0
KLHL41; BBS5
IUUC-Cja-019650
ENSCJAG00000006088.2
F7IQE8
KLHL8
IUUC-Cja-019183
ENSCJAG00000006075.2
F7ISP0
KLHL3
IUUC-Cja-019290
ENSCJAG00000005305.1
F7EFD1
KBTBD12
IUUC-Cja-019972
ENSCJAG00000002447.2
F6W7Y7
KLHL9; KLHL13
IUUC-Cja-019847
ENSCJAG00000002386.2
F7CKM5
KLHL18
IUUC-Cja-019038
ENSCJAG00000001422.2
F7I6U5
KLHL7
IUUC-Cja-019411
ENSCJAG00000000837.1
F6X6X0
KLHL38
IUUC-Cja-019953
ENSCJAG00000000789.2
F7BIT5
KLHL5
IUUC-Cja-019501
ENSCJAG00000000233.2
F7H8M4
KLHL21
IUUC-Cja-019472
ENSCJAG00000000001.2
H9KVI7