Equus caballus         E3 adaptor/Cullin RING/BCR/BTB_3-box


※ E3 adaptor/Cullin RING/BCR/BTB_3-box family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_3-box family as the proteins contain both BTB domain and 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID: 16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 35 genes.  Reviewed (0 or Unreviewed (35Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Eca-034191
ENSECAG00000021494.2
F6ZV22
KLHL11
IUUC-Eca-033570
ENSECAG00000026890.1
F6T144
KLHL21
IUUC-Eca-033507
ENSECAG00000024577.1
F6QQP1
KLHL18
IUUC-Eca-033435
ENSECAG00000024001.1
F6Z5R0
KBTBD2
IUUC-Eca-033856
ENSECAG00000023217.1
F6TRD6
KLHL17
IUUC-Eca-033887
ENSECAG00000022073.1
F6WHB6
KLHL3
IUUC-Eca-033498
ENSECAG00000021791.1
F6Y9Z7
RCBTB1
IUUC-Eca-034237
ENSECAG00000021523.1
F6XWF4
KLHL10
IUUC-Eca-034390
ENSECAG00000021066.1
F6URN2
KLHL24
IUUC-Eca-034381
ENSECAG00000020533.1
F6VZG9
KEAP1
IUUC-Eca-033525
ENSECAG00000018938.1
F7A2I9
KLHL1
IUUC-Eca-034393
ENSECAG00000018580.1
F7BPW3
KLHL40
IUUC-Eca-033238
ENSECAG00000018287.1
F7A1J9
SPOP
IUUC-Eca-033213
ENSECAG00000018323.1
F7CI74
KLHL23
IUUC-Eca-034162
ENSECAG00000017829.1
F6QCL2
KLHL8
IUUC-Eca-033651
ENSECAG00000016706.1
F6X122
ENC1
IUUC-Eca-033608
ENSECAG00000016531.1
F6X6S1
KLHL6
IUUC-Eca-033282
ENSECAG00000015828.1
F6TWL2
KLHL12
IUUC-Eca-033203
ENSECAG00000015694.1
F6VRK2
IPP
IUUC-Eca-033714
ENSECAG00000015659.1
F6W4S0
KLHL41
IUUC-Eca-033388
ENSECAG00000015363.1
F6UYJ8
KLHL22
IUUC-Eca-033751
ENSECAG00000014000.1
F6ZQT2
KLHL20
IUUC-Eca-033858
ENSECAG00000013631.1
F6ZY93
SPOPL
IUUC-Eca-033326
ENSECAG00000013455.1
F7BD32
KLHL42
IUUC-Eca-034092
ENSECAG00000012155.1
F6T7B9
GAN
IUUC-Eca-033798
ENSECAG00000010727.1
F7BX08
KLHL2
IUUC-Eca-034041
ENSECAG00000010574.1
F7DQ07
KLHL7
IUUC-Eca-034002
ENSECAG00000008627.1
F6XX39
KLHL5
IUUC-Eca-034150
ENSECAG00000008626.1
F6UIQ7
KLHL28
IUUC-Eca-033771
ENSECAG00000008237.1
F6U5J5
KLHL13
IUUC-Eca-033974
ENSECAG00000007032.1
F7D983
KLHL29
IUUC-Eca-033542
ENSECAG00000002157.1
F6SJZ3
KLHL4
IUUC-Eca-034407
ENSECAG00000003990.1
F6XYH4
IUUC-Eca-034344
ENSECAG00000001410.1
F7CVX2
KBTBD6
IUUC-Eca-034128
ENSECAG00000001308.1
F7D6Y0
KBTBD7