Macropus eugenii         E3 adaptor/Cullin RING/BCR/BTB_3-box


※ E3 adaptor/Cullin RING/BCR/BTB_3-box family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_3-box family as the proteins contain both BTB domain and 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID: 16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 29 genes.  Reviewed (0 or Unreviewed (29Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Meu-056011
ENSMEUG00000016751.1
KLHL2
IUUC-Meu-056012
ENSMEUG00000014271.1
IUUC-Meu-056158
ENSMEUG00000014259.1
KLHL10
IUUC-Meu-056605
ENSMEUG00000013872.1
KLHL20
IUUC-Meu-055972
ENSMEUG00000013574.1
KLHL40
IUUC-Meu-056028
ENSMEUG00000013225.1
KLHL28
IUUC-Meu-056835
ENSMEUG00000011909.1
KLHL38
IUUC-Meu-056095
ENSMEUG00000011485.1
IUUC-Meu-056859
ENSMEUG00000011225.1
KLHL4
IUUC-Meu-056288
ENSMEUG00000011169.1
KEAP1
IUUC-Meu-056871
ENSMEUG00000010614.1
KLHL18
IUUC-Meu-056657
ENSMEUG00000010522.1
KLHL41
IUUC-Meu-056272
ENSMEUG00000010185.1
KBTBD3
IUUC-Meu-056893
ENSMEUG00000009408.1
KLHL25
IUUC-Meu-056801
ENSMEUG00000008845.1
KLHL29
IUUC-Meu-056770
ENSMEUG00000008683.1
IUUC-Meu-056661
ENSMEUG00000008187.1
IUUC-Meu-056330
ENSMEUG00000007185.1
SPOP
IUUC-Meu-056812
ENSMEUG00000005663.1
KLHL17
IUUC-Meu-056851
ENSMEUG00000004752.1
IUUC-Meu-056500
ENSMEUG00000003903.1
IUUC-Meu-056474
ENSMEUG00000003547.1
IUUC-Meu-056763
ENSMEUG00000002285.1
ENC1
IUUC-Meu-056779
ENSMEUG00000002203.1
KLHL8
IUUC-Meu-056366
ENSMEUG00000002073.1
KLHL24
IUUC-Meu-056183
ENSMEUG00000001840.1
IUUC-Meu-055982
ENSMEUG00000001648.1
KLHL23
IUUC-Meu-056415
ENSMEUG00000001328.1
GAN
IUUC-Meu-056358
ENSMEUG00000000215.1
KLHL30