Monodelphis domestica         E3 adaptor/Cullin RING/BCR/BTB_3-box


※ E3 adaptor/Cullin RING/BCR/BTB_3-box family introduction

    BTB (also known as POZ) was first identified as a conserved motif presented in the Drosophila melanogaster Bric-a-Brac, Tramtrack, Broad complex transcription regulators (1). BTB, Cul3 and RBX1 form a Cul3-based ligase (BCR), which targets substrates for ubiquitin-dependent degradation by the 26S proteasome. As a substrate recognition subunit of Cul3-based ligase, the member of BTB family can bridge the Cul3 to the substrate in a single polypeptide (2,3). Recently, it was observed that a 3-box is responsible for the Cul3-interacting in a variety of BTB proteins including almost all of BTB-Kelch and MATH-BTB proteins (4). Here we defined the BTB_3-box family as the proteins contain both BTB domain and 3-box domain. BTB-containing proteins are highly conserved and participate in diverse biological processes, including transcriptional regulation, ion channel assembly and gating, cytoskeleton dynamics, and targeting proteins for ubiquitination (1).

1. Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K. and Prive, G.G. (2005). Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, R82. PMID: 16207353

2. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J. and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature, 425, 316-321. PMID: 13679922

3. Pintard, L., Willems, A. and Peter, M. (2004). Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J., 23, 1681-1687. PMID: 15071497

4. Zhuang, M., Calabrese, M.F., Liu, J., Waddell, M.B., Nourse, A., Hammel, M., Miller, D.J., Walden, H., Duda, D.M., Seyedin, S.N., Hoggard, T., Harper, J. W., White, K. P. and Schulman, B. A.. (2009). Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell, 36(1): 39-50. PMID: 19818708




There are 37 genes.  Reviewed (0 or Unreviewed (37Download the gene list
StatusiUUCD IDEnsemble Gene IDUniProt AccessionGene Name
IUUC-Mdo-061869
ENSMODG00000011266.3
K7E5D7
KLHL13
IUUC-Mdo-061995
ENSMODG00000025244.1
F7F5Y4
ENC1
IUUC-Mdo-062472
ENSMODG00000001195.3
F6X9F5
SPOPL
IUUC-Mdo-062667
ENSMODG00000024689.1
F7FDD3
KLHL25
IUUC-Mdo-062291
ENSMODG00000024594.2
F6PUR2
KBTBD13
IUUC-Mdo-062205
ENSMODG00000023874.1
F7G9P4
LOC100027335
IUUC-Mdo-063033
ENSMODG00000013426.3
F7EDI1
KLHL6
IUUC-Mdo-062664
ENSMODG00000021551.4
F7DEY8
KBTBD2
IUUC-Mdo-062785
ENSMODG00000021177.3
H9H7W1
KLHL4
IUUC-Mdo-062527
ENSMODG00000020741.3
F7A032
KLHL8
IUUC-Mdo-062687
ENSMODG00000020538.3
F7EN90
KLHL5
IUUC-Mdo-061803
ENSMODG00000015931.3
F6ZQK9
KLHL30
IUUC-Mdo-062539
ENSMODG00000015214.3
F6V4G7
GAN
IUUC-Mdo-062923
ENSMODG00000014989.3
F7BXS6
KLHL3
IUUC-Mdo-062879
ENSMODG00000014748.3
F7GGS9
IUUC-Mdo-062546
ENSMODG00000014731.4
F6ZCQ5
KBTBD3
IUUC-Mdo-062082
ENSMODG00000014725.2
F6ZD39
KLHL11
IUUC-Mdo-062138
ENSMODG00000014695.3
F7DN26
KLHL10
IUUC-Mdo-062068
ENSMODG00000014421.3
F7BH48
KLHL42
IUUC-Mdo-062285
ENSMODG00000014078.3
F6R519
KLHL18
IUUC-Mdo-062563
ENSMODG00000013585.3
F7AVX2
KLHL40
IUUC-Mdo-062542
ENSMODG00000013472.2
F7FML9
LOC100027066
IUUC-Mdo-062179
ENSMODG00000013469.2
F7FMX4
LOC100027105
IUUC-Mdo-063082
ENSMODG00000013433.3
F7GIN1
KLHL24
IUUC-Mdo-062637
ENSMODG00000010861.3
F7FW94
RCBTB1
IUUC-Mdo-062419
ENSMODG00000008183.3
F7E4D6
KLHL23
IUUC-Mdo-062776
ENSMODG00000007505.3
F7GK24
KLHL28
IUUC-Mdo-062072
ENSMODG00000005745.3
F6QE74
KEAP1
IUUC-Mdo-062242
ENSMODG00000004130.3
F6UVL8
KLHL20
IUUC-Mdo-063061
ENSMODG00000003276.3
F7EYU1
KBTBD8
IUUC-Mdo-062977
ENSMODG00000002334.3
F7GLX9
KLHL2
IUUC-Mdo-062064
ENSMODG00000002208.3
F7G3K2
IPP
IUUC-Mdo-062142
ENSMODG00000001944.3
F6VJV6
KLHL38
IUUC-Mdo-062729
ENSMODG00000001075.3
F7GI05
KLHL7
IUUC-Mdo-061990
ENSMODG00000000855.3
F7BHT0
KLHL12
IUUC-Mdo-062095
ENSMODG00000000252.3
H9H5V2
KLHL21
IUUC-Mdo-062369
ENSMODG00000000124.3
F6YBQ3
KLHL1