PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q38942 Q84JU6 affinity chromatography technology 21189294 physical association X 2 Q84JU6 Q9LSE2 pull down 23010172 direct interaction X 2 Q84JU6 O22607 two hybrid 22960247 direct interaction X 2 Q84JU6 Q9LSE2 two hybrid 22960247 direct interaction X 2 Q84JU6 O22607 affinity chromatography technology 22960247 physical association X 2 Q84JU6 O22607 affinity chromatography technology 22960247 physical association X 2 Q84JU6 Q39057-2 two hybrid 23135282 direct interaction X 2 Q84JU6 Q39057-2 pull down 23135282 direct interaction X 2 Q84JU6 Q39057-2 protein complementation assay 23135282 direct interaction X 2 Q84JU6 O22607 two hybrid 24220632 direct interaction X 2 Q84JU6 O22607 pull down 24220632 direct interaction X 2 Q84JU6 O22607 affinity chromatography technology 24220632 physical association X 2 Q84JU6 O22607 protein complementation assay 24220632 direct interaction X 2 Q84JU6 Q8GXJ1 pull down 24220632 direct interaction X 2 Q84JU6 Q8GXJ1 protein complementation assay 24220632 direct interaction X 2 Q84JU6 Q8H0W2 two hybrid 24220632 direct interaction X 2 Q84JU6 Q8GXJ1 two hybrid 24220632 direct interaction X 2 Q84JU6 Q9LSE2 two hybrid 16702557 direct interaction X 2 Q84JU6 Q9LSE2 enzymatic study 16702557 direct interaction X 2 Q84JU6 Q9LSE2 pull down 16702557 direct interaction X 2 Q84JU6 Q9LSE2 protein complementation assay 16702557 direct interaction X 2 Q84JU6 affinity chromatography technology 21189294 physical association X 2 Q84JU6 Q9FWS3-2 affinity chromatography technology 21189294 physical association X 2 Q84JU6 Q39057-2 pull down 22408073 direct interaction X 2 Q84JU6 Q39057-2 protein complementation assay 22408073 direct interaction X 2 Q84JU6 Q39057-2 affinity chromatography technology 22408073 physical association X 2 Q84JU6 two hybrid 22960247 direct interaction X 2 Q84JU6 affinity chromatography technology 22960247 physical association X 2 Q84JU6 affinity chromatography technology 22960247 physical association X 2 Q84JU6 Q9FML2 two hybrid 24220632 direct interaction X 2 Q84JU6 Q9FML2 pull down 24220632 direct interaction X 2 Q84JU6 Q9FML2 affinity chromatography technology 24220632 physical association X 2 Q84JU6 Q9FML2 protein complementation assay 24220632 direct interaction X 2 Q84JU6 Q8RX28 two hybrid 24220632 direct interaction X 2 Q84JU6 Q9LSE2 two hybrid 16702557 direct interaction X 2 Q84JU6 Q9LSE2 bimolecular fluorescence complementation 16702557 direct interaction X 2 Q84JU6 Q9LSE2 pull down 16702557 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CO HOS1 MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 22408073,23135282 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_15470|BIOGRID_16897|BIOGRID_15468|BIOGRID_16896|BIOGRID_15469|BIOGRID_16895 prey|bait|prey|bait|prey|prey bait|prey|bait|prey|bait|bait At4g30840 HOS1 MI:0004(affinity chromatography technology) 21189294 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_6158 bait prey At1g80670 HOS1 MI:0004(affinity chromatography technology) 21189294 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_5919 bait prey HOS1 SCRM MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16702557,22960247,23010172 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_5879|BIOGRID_16785|BIOGRID_16756|BIOGRID_3362|BIOGRID_5880|BIOGRID_3364 bait|prey|bait|bait|bait|bait prey|bait|prey|prey|prey|prey HOS1 HDA6 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 24220632 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_20318|BIOGRID_20320|BIOGRID_20312|BIOGRID_20313 bait|bait|bait|bait prey|prey|prey|prey HOS1 HDA15 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 24220632 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_20329|BIOGRID_20314|BIOGRID_20322 bait|bait|bait prey|prey|prey HOS1 HDA5 MI:0018(two hybrid) 24220632 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_20330 bait prey HOS1 HDA9 MI:0018(two hybrid) 24220632 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_20328 bait prey HOS1 F7O18.9 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 22960247 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_16784|BIOGRID_16787|BIOGRID_16789 prey|prey|bait bait|bait|prey HOS1 At1g75340 MI:0004(affinity chromatography technology) 21189294 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (biogrid) BIOGRID_6431 prey bait

PPI - HINT Gene A Gene B PMID Method Quality MSI4 HOS1 24220632,22960247,22960247,24220632,24220632,24220632 0004,0018,0004,0096,0090,0018 LC CO HOS1 22408073,22408073,23135282,23135282,23135282,22408073 0090,0096,0090,0018,0096,0004 LC HOS1 HDA15 24220632,24220632,24220632 0096,0090,0018 LC HOS1 HDA9 24220632 0018 LC HOS1 HDA5 24220632 0018 LC HOS1 SRK2E 25669882,25669882 0004,0018 LC HOS1 HDA6 24220632,24220632,24220632,24220632 0096,0018,0004,0090 LC HOS1 SCRM2 26311645,26311645,26311645,26311645 0018,0055,0415,0096 LC HOS1 SCRM 16702557,16702557,16702557,22960247,16702557,17416732,16702557 0415,0018,0809,0018,0090,0415,0096 LC HOS1 FLK 22960247,22960247 0018,0004 LC MSI4 HOS1 24220632,22960247,22960247,24220632,24220632,24220632 0004,0018,0004,0096,0090,0018 LC NUP43 HOS1 21189294 0004 HT RAE1 HOS1 21189294 0004 HT CO HOS1 22408073,22408073,23135282,23135282,23135282,22408073 0090,0096,0090,0018,0096,0004 LC HOS1 HDA15 24220632,24220632,24220632 0096,0090,0018 LC HOS1 SRK2E 25669882,25669882 0004,0018 LC HOS1 HDA6 24220632,24220632,24220632,24220632 0096,0018,0004,0090 LC HOS1 CG1 21189294 0004 HT HOS1 SCRM2 26311645,26311645,26311645,26311645 0018,0055,0415,0096 LC HOS1 SCRM 16702557,16702557,16702557,25669882,16702557,16702557,23010172 0415,0018,0809,0096,0090,0096,0096 LC HOS1 FLK 22960247,22960247 0018,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9FWS3 Q84JU6 Q9FWS3 HOS1 0.126 21189294 Q9LSE2 Q84JU6 SCRM HOS1 0.948 16702557,22960247,25669882,17416732,23010172 Q8H0W2 Q84JU6 HDA9 HOS1 0.309 24220632 Q8RX28 Q84JU6 HDA5 HOS1 0.309 24220632 Q9SR13 Q84JU6 FLK {ECO:0000303|PUBMED:14593172} HOS1 0.569 22960247 Q84JU6 Q39057 HOS1 CO 0.876 23135282,22408073 Q84JU6 O22607 HOS1 MSI4 0.888 24220632,22960247 Q8GXJ1 Q84JU6 HDA15 HOS1 0.671 24220632 Q9LPW3 Q84JU6 SCRM2 HOS1 0.772 26311645 Q9FML2 Q84JU6 HDA6 HOS1 0.74 24220632 Q940H6 Q84JU6 SRK2E HOS1 0.454 25669882 Q84JU6 Q24JJ9 HOS1 NUP43 {ECO:0000303|PUBMED:21189294} 0.126 21189294 Q84JU6 Q38942 HOS1 Q38942 0.126 21189294