PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GNB2 RASD2 19255495 biogrid exp P G GP G G GP G P P P G P GP GP G G G G GP P P G GSK3B RASD2 19888210 i2d exp G GP G G GP G G GP G G P G G G G G SMAD2 RASD2 15761153 hprd,i2d exp P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G LRP5 RASD2 26186194 biogrid exp P P G G GP P P P G P P GP G P GP G GP GP P P G NKD2 RASD2 19888210 i2d exp P G GP G G GP G P P G P GP GP P GP G GP GP P G RASD2 SMURF2 15761153 hprd,i2d exp G G G G G G G G G G G G G G G GNB3 RASD2 19255495 biogrid exp P G GP G G GP G P P P G P GP GP G G G G GP P P G RASD2 SLC4A7 26186194 biogrid exp G G G G G G G P G G G G G GP G RASD2 AXIN2 19888210 i2d exp P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G SMAD3 RASD2 15761153 hprd,i2d exp P G GP G G G G P G GP GP G P G G G G G LRP6 RASD2 26186194 biogrid exp P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G BMPR1B RASD2 15761153 hprd,i2d exp P G GP G G GP G P P P P GP GP G P GP GP GP P P G DVL2 RASD2 19888210 i2d exp P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G SMAD4 RASD2 15761153 hprd,i2d exp P G GP G G GP G P P P G P GP GP G P GP G G GP P P G CSNK1A1 RASD2 19888210 i2d exp G G G G G G G G GP G G G G G G TGFBR1 RASD2 15761153 hprd,i2d exp G GP G G GP G P P P G P GP G G G G G GP P G ACVR1 RASD2 15761153 hprd,i2d exp P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G SMAD1 RASD2 15761153 hprd,i2d exp G G G G GP G G G G G G G G G P G RASD2 SMURF1 15761153 hprd,i2d exp P G GP G G GP G P P G GP G G P G G G G P G RAP1GDS1 RASD2 26186194 biogrid exp P G GP G G GP G P P G P GP GP G P G G GP GP P P G PIK3CA RASD2 14724584 hprd,biogrid exp P G GP G G GP G P P P G P GP GP G P GP G GP GP P P CSNK1E RASD2 19888210 i2d exp P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RABAC1 19060904, 25402006 biogrid,intact exp, pred G GP G G GP G P P P G P GP GP G P GP G GP GP P P G GNB1 RASD2 19255495, 23023127 biogrid exp, pred P G GP G G GP G P P P G P GP GP G G G G GP P P G RAF1 RASD2 14724584, 23023127 biogrid exp, pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 NIF3L1 25402006 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G FGD1 RASD2 23023127 pred P G GP G G G G P G GP G G P GP G G G P P G MIEF2 RASD2 25402006 pred P G GP G G GP G P P G P GP GP G GP G G GP P P G DIRAS3 RASD2 23023127 pred P G GP G P G P P P GP GP G P GP P GP P P RASD2 IFT27 23023127 pred G GP G G GP G P P P G P GP G G G G G GP P G MAP2K1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RABL2A 23023127 pred P P P P P P P P P P P P P MCF2L2 RASD2 23023127 pred P P P P P P P P P P P P P P P RAB11FIP2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 FARP1 23023127 pred G G G G G G P P G P G GP G G G G GP P G FEZF2 RASD2 23023127 pred G G G RGL4 RASD2 23023127 pred P P P P P P P P P APBA1 RASD2 23023127 pred P G GP G G P G P P P G P GP P G P P G GP GP P P G VAV1 RASD2 23023127 pred P GP G P G P P P G P GP GP G P G G P P P P G RAC2 RASD2 23023127 pred P G GP G G G G P G GP G G GP G GP G P G MLK4 RASD2 23023127 pred P G GP G GP G P P P G P GP GP G P G G GP P P G RAB6A RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G GEM RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P G G GP GP P P G RHEBL1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P P GP P P P G RASD2 GNB4 21836163 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAPGEF1 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G ARFIP2 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G G GP P P G EXOC8 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G RAB2B RASD2 23023127 pred G GP G G G G G GP G G G G G G G RASD2 PAK6 23023127 pred G GP G G GP G P P G P GP GP G P G G P GP P P RASD2 ITSN2 23023127 pred G GP G G GP G P P G P GP GP G P GP G G GP P P G RHOT1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G ARFGEF3 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RGS14 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RGS4 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP P P G RASD2 NKIRAS1 23023127 pred G G G G G G G G G G G G G G G SOS2 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G GNAQ RASD2 23023127 pred P G GP G G GP G P P G P GP GP G GP G G GP P P G RHOU RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G ARHGDIA RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G PSD RASD2 23023127 pred G G G G G P P G G G GP G RASD2 PSD3 23023127 pred G G G G G G G G G G G G G G G ARL4A RASD2 23023127 pred G G G G G G G G G G G G G G ARHGAP32 RASD2 23023127 pred P G GP G G GP G P G P GP GP G P G G GP GP P P G RHOH RASD2 23023127 pred P P GP P P P G P P P P GP G GP P P G RAB43 RASD2 23023127 pred P P P P P P P P P P P P P RHOG RASD2 23023127 pred P G GP G G G G P P G GP G G G G G G G RASD2 FGD4 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G PLEKHM3 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 ARFGEF2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G ROCK1 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G G GP P P G RASD2 CAMKK2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G ARHGAP5 RASD2 23023127 pred P G GP G G GP G P G GP GP G G G G G P G Ras-related protein Rap-1b-like protein RASD2 23023127 pred RAB30 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 WDYHV1 25402006 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G FGD6 RASD2 23023127 pred P P P P P P P P P P P P P P P G PARK2 RASD2 23023127 pred P G GP G G GP G P P P P GP P G P G GP GP P P G TIAM1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G P GP P P G RGL3 RASD2 23023127 pred P G GP G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 ARHGDIG 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G MPP1 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G G GP P G RASD2 RGL1 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RIN2 RASD2 23023127, 16082366 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB40A RASD2 23023127 pred SUMO2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G ARHGEF7 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RAB21 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G HDAC4 RASD2 23023127 pred G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RRAS2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 ARL5B 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G DCLK1 RASD2 23023127 pred G GP G G GP G G P GP GP G P G G G GP P P G SBF1 RASD2 23023127 pred G G G G G G G G G G G G G G G CAMKK1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAC3 RASD2 23023127 pred P P P P P P P P P P P GARNL3 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB40AL RASD2 23023127 pred G ARL4D RASD2 23023127 pred G G G G GP G P P G P G GP G P G G G GP P P G RASD2 RAP2C 23023127 pred G G G G G G G G G G G G G G G FGD2 RASD2 23023127 pred G G G G GP G P P P G P G GP G G G G GP P G RAB8B RASD2 23023127 pred G G G G G G G G G G G G G G G RASD2 RHOF 23023127 pred G GP G G GP G G P GP G G P G G G GP P G RAB36 RASD2 23023127 pred G G G G G G G G G G G G G G G RAB4A RASD2 23023127 pred P P P P P P P P P P P P P P P RASAL1 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P P G GP GP P P G RAB1C RASD2 23023127 pred RASD2 RHOV 23023127 pred G G P G G G GP G P RASD2 RHOJ 23023127 pred P G GP G G GP G P P P G P GP P G P GP G GP GP P P G RAB24 RASD2 23023127 pred G G G G G G G G G G G G G G G MAP3K10 RASD2 23023127 pred P P P P P P P P P P P P P P GNA13 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RGS22 RASD2 21836163 pred P P P P P P P P P G P P P P P G RERG RASD2 23023127 pred P G GP G G GP G P P G P GP GP G G GP GP P P G SRGAP3 RASD2 23023127 pred G GP G G GP G P G GP G G G G GP G ARF6 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G RAB11A RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 COL4A3BP 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 ALS2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G PREX2 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G RASD2 RASAL2 23023127 pred P G GP G G GP G P P G GP G P G G G G P P G RASGRF2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP GP GP P P G MAP3K9 RASD2 23023127 pred P G GP G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 UBQLN1 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G GAPVD1 RASD2 23023127 pred P G GP G G GP G P G P GP GP G P GP G G GP P P G RAB5A RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RAB20 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G P GP P P G PTPN3 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB4B RASD2 23023127 pred G G G G G G G G G G G RASD2 BTRC 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAP2B RASD2 23023127 pred G G G G G G G G G G G G G G G RASD2 RIT2 23023127 pred G G G G G SOS1 RASD2 23023127 pred G G G G GP G P P G P G GP G P GP G GP GP P G ARHGEF11 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G ARHGAP6 RASD2 23023127 pred P G GP G G GP G P P P G P GP P G P GP G GP GP P P G RANBP2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 CAMK1G 23023127 pred P G GP G G P G P P P P GP GP P P G P P P P G PAK1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G MCF2L RASD2 23023127 pred G GP G G GP G P P P G GP GP G P GP G GP G P G MAPK8IP2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G PSD4 RASD2 23023127 pred P P G GP P G P P GP G GP G GP P P ARHGAP31 RASD2 23023127 pred P G GP G G GP G P P P G P GP G G P GP G G GP P P G USP14 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAPGEF5 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G P GP P P G RAB15 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P G G GP GP P P G RRAD RASD2 23023127 pred P P G GP P P P G P P P P P GP GP P P G ARHGEF9 RASD2 23023127 pred P G GP G G GP G P P G GP GP G P G G P G P G RAB5B RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB10 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB25 RASD2 23023127 pred P P GP P P P G P P GP G P GP G P GP P P G RASD2 PLEKHA6 23023127 pred G GP G G GP G P P G P GP P G P GP G GP P P G SUMO3 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB41 RASD2 23023127 pred P P P P P P P P P P P P P PAK2 RASD2 23023127 pred P G GP G G GP G P P P G P GP G G P G G GP GP P G PKN1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RASD1 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB7A RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RND2 RASD2 23023127 pred G G G G G G G G G G G RASL10A RASD2 23023127 pred G GP G G GP G P G P GP G G G G GP G GNAO1 RASD2 23023127 pred P G GP G G GP G GP GP G G G G G RASD2 DIRAS2 23023127 pred P G GP G P G P P P P GP P G P G P P P P RASD2 ARHGAP26 23023127 pred P G GP G G GP G P P G P GP GP G P GP G G GP P P G RASD2 AGAP3 23023127 pred P G GP G G GP G P P P P GP P G P P G GP GP P P G RASD2 NPTN 23023127 pred G GP G G GP G P P G P GP G G G G G GP P G RASA1 RASD2 23023127 pred G GP G G G G G GP G G P G G G G P G RAP1GAP RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G RIN1 RASD2 16082366 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G GNAZ RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P G G G GP P P G RASD2 DOCK9 23023127 pred P G GP G G GP G P P P G P GP P G P GP G GP GP P P G ARHGEF25 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G GP GP GP P P G CAMTA2 RASD2 23023127 pred G G G G G G G G G G G G G G G ARF5 RASD2 23023127 pred G G G G G G G G G G G G G G G RASAL3 RASD2 23023127 pred P G G G G G G P G G G G G G G G RHOT2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G TRIM23 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB13 RASD2 23023127 pred G GP G G GP G P P G GP GP G P GP G G G P P G RAB12 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RGS10 RASD2 21836163 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RHOD RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P G G GP GP P P G GNAL RASD2 23023127 pred P G GP G G GP G P P P G P GP P G P GP G GP GP P P G RALGPS2 RASD2 23023127 pred P P G GP P P P G P P P GP P GP P P RAB31 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G RGS11 RASD2 21836163 pred P G GP G P G P P P P GP GP G P P P P P P WDR5B RASD2 23023127 pred P G GP G G GP G P P G P GP GP G G G GP GP P P G RAB27B RASD2 23023127 pred P G GP G G GP G P P G P GP GP G GP G GP GP P P G RIT1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 23023127 pred RASD2 RAB39B 23023127 pred G GP G P G P P P GP P G P P P P P DGKZ RASD2 23023127 pred G GP G G G G G GP GP G G G G G P P G PI4KA RASD2 23023127 pred P G GP G G GP G P P P G GP GP G P G G GP G P G RND1 RASD2 23023127 pred G G G G G G G G G G G RAB39A RASD2 23023127 pred G GP G G GP G P G P GP GP G G G G GP P P G ARHGEF37 RASD2 23023127 pred P G GP G G GP G P G P GP P G P G G G GP P P G GNA12 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB40B RASD2 23023127 pred G G G G G G G G G G G G G G G NEDD8 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RALBP1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RAB9B 23023127 pred P G GP G G GP G P P P P GP GP G GP G GP GP P P G RASL11A RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P P G GP GP P P G RASGRP1 RASD2 23023127 pred G G G G G G G G RASD2 PLEKHF2 25402006 pred G GP G G GP P P G P GP GP G P GP G G GP P P G RASD2 ARHGEF3 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 MYO15A 23023127 pred G GP G G GP G P G P GP GP G P G G GP GP P P G ERAS RASD2 23023127 pred NET1 RASD2 23023127 pred G GP G G GP G P G GP G G P G G GP G P G MAPK3 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RERGL 23023127 pred P GP G GP G P P P G P GP P P GP P GP P P G RASD2 PLCE1 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 NKIRAS2 23023127 pred G G G G G G G G G G G G G G G RND3 RASD2 23023127 pred G G G G G G G G G G G G G G G RASD2 SYNGAP1 23023127 pred P G GP G G GP G P G GP G G GP G P G RAP1GAP2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G P GP P P RAB28 RASD2 23023127 pred P G GP G G GP G P P G P GP G G G G GP GP P P G RAB5C RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G CHN1 RASD2 23023127 pred G G G G G G G G G G G G G PRKCG RASD2 23023127 pred G GP G G G G GP G G G G RASD2 RAB6C 23023127 pred P P P P P P P P P P P P P P P RABL3 RASD2 23023127 pred G GP G G GP G P P P G P GP GP G P GP G GP GP P P G NGEF RASD2 23023127 pred P G GP G GP G P P P G P GP GP P GP P GP P P G RABIF RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G CDC42 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G DIRAS1 RASD2 23023127 pred P G GP G G P G P P P GP P G P G P P P P G RASD2 ARL5A 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G RASD2 RAB3C 23023127 pred P G GP G P G P GP P G P P P P RASD2 AGAP2 23023127 pred P G GP G P G P P P P GP P G P P GP P P P G RALA RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAP1A RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RALB RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G G GP P P G PRKCB RASD2 23023127 pred P G GP G G GP G P P G GP GP G GP G G G P P G RASD2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G IQSEC1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RABL2B 23023127 pred P P P P P P P P P P P P P P RASD2 FAM49A 23023127 pred P G GP G GP G P P P G P GP P G P GP GP GP P P G RAB38 RASD2 23023127 pred G RAP2A RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB3B RASD2 23023127 pred P G G GP G P G GP G P GP GP P RAB1A RASD2 25402006, 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G RALGPS1 RASD2 23023127 pred G G G G G G G G G G G G G ARFRP1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB2A RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G GNAI1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASGRP3 RASD2 23023127 pred G G G G G G G G G G PAFAH1B1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RAB22A 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB37 RASD2 23023127 pred G G G G G P P G G P G RAPGEF4 RASD2 23023127 pred P G GP G G GP G P P P P GP P G P P P P P P TRIO RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G PREX1 RASD2 21836163 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G RASD2 RAB23 23023127 pred P G GP G G GP G P P P G P GP P G P GP G GP GP P P G RASD2 G3BP2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G CDK5 RASD2 23023127 pred P G GP G P G P P P P GP P G P G P P P P ARL3 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G ULK1 RASD2 23023127 pred G G G G G G G G G G G G G G G REM1 RASD2 23023127 pred G GP G G GP G P P P G P GP GP G P GP G G GP P P G RAC1 RASD2 23023127 pred P G G G G GP G P G P G GP G P GP G GP GP P P G RHOB RASD2 23023127 pred P G GP G G G G P G GP GP G P G G G G P P G RASD2 FAM13B 23023127 pred G GP G G GP G P P G P GP GP G P GP G GP GP P P G RASD2 RAB17 23023127 pred P G GP P P P G P P GP G P GP G GP GP P P G RAB3D RASD2 23023127 pred P G GP G G GP G P G P GP GP G P GP G GP GP P P G PEBP1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G GP G GP GP P P G RAB27A RASD2 23023127 pred P G GP G G GP G P G P GP GP G P GP G GP P P G NRAS RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G KALRN RASD2 23023127 pred P G GP G P G P P P P GP P P P P P P P RASD2 SPTBN4 23023127 pred P G GP G GP G P P P P GP G P P GP P P P RAB33A RASD2 25402006, 23023127 pred P G GP G G P G P P P GP GP G G G P P P G RASD2 RAB26 23023127 pred G G G G GP G P P G P G G G P GP G GP GP P P G REM2 RASD2 23023127 pred G G G RASD2 STMN3 23023127 pred G GP G G GP G P P G GP GP G G G GP G G PRKCZ RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G P GP P P ROCK2 RASD2 23023127 pred P G GP G G GP G P G P GP GP G P GP G GP GP P P G RHEB RASD2 23023127 pred G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 DNAJC27 23023127 pred P G GP G G GP G P P P G P GP P G P GP G GP GP P P G GDI1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G GBF1 RASD2 23023127 pred P G GP G G GP G P G P GP GP G P GP G GP GP P G GNG5 RASD2 21836163 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RHOA RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G MCF2 RASD2 23023127 pred P G GP G P G P P P P GP P G P P P P P P RAB9A RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G RAB11B RASD2 23023127 pred G G G G G G G G G G G G G G G RASD2 ARL8B 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G RASD2 UBQLN2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 AGAP1 23023127 pred G GP G G GP G P P G GP G G P GP G G G P G RASD2 RAB33B 23023127 pred P G G G G GP G G G G G G G G G P P G RAB35 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G ARL4C RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P G G P GP P P G RASD2 RAB6B 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G ABR RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAPGEF3 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP P GP G GP P P P G RASEF RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB29 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RHOC RASD2 23023127 pred P P G P P G RAB42 RASD2 23023127 pred G G G G G G G G G G G G G G G RASA2 RASD2 23023127 pred P G GP G G GP G P P P G P GP G G P GP G G GP P P G RASD2 RNF14 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 PRPF19 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 IFT22 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RALGDS RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G VAV2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP P P G KRAS RASD2 23023127 pred G GP G G GP G P G P GP GP G GP G GP GP P P G AMPH RASD2 23023127 pred G GP G G GP G G GP GP G G G G G G PAK4 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G ITSN1 RASD2 23023127 pred P G GP G G GP G P P P G P GP G G P G G GP GP P P G HRAS RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RAB14 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G GNGT1 RASD2 21836163 pred P P P P MRAS RASD2 23023127 pred P G GP G G GP G P P P G P GP P G P GP G GP GP P P G RASD2 ARL15 23023127 pred P G GP G G GP G P G P GP GP G G G GP GP P G RPS6KA2 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RNF41 23023127 pred P G GP G G GP G P P G P GP P G P G GP GP P P RASGEF1A RASD2 23023127 pred P G GP G GP G P P G GP GP G P P G P G P P G RASD2 ARL6 23023127 pred P G GP G G GP G P P P G P GP GP G P G G GP GP P P DAB2IP RASD2 23023127 pred G GP G G G G P G GP GP G GP G G G G ARHGAP1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G DZIP3 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G PTK2B RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G G GP P P G RAB32 RASD2 23023127 pred P G GP G G GP G P P P G P GP G G P GP G GP GP P P G RASD2 PLK2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RASL11B 23023127 pred P G GP G G G G P P G P GP G G P G G G GP P P G SUMO1 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G RHOQ RASD2 23023127 pred G G G G G G G G G G G G G G G HUWE1 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G ARL2 RASD2 23023127 pred P G GP G G GP G P P G P GP GP G P GP G GP GP P P G ARL1 RASD2 23023127 pred G G G G G G G G G G G G G G G ARL11 RASD2 23023127 pred P P P P P P P P P P P P P P P ARL8A RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G ARF3 RASD2 23023127 pred G G G G G G G G G G G G G G G ARHGEF39 RASD2 23023127 pred P G GP G G GP P P P G P GP G G P P G G GP P P RAB3A RASD2 23023127 pred P G GP G G G G GP GP G G G G G ARHGAP4 RASD2 23023127 pred G P G G RASD2 RASL10B 23023127 pred G G G G G G G G G G G RAPGEF6 RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RRAS RASD2 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RAPGEFL1 23023127 pred G GP P G P P P GP P P P P P P RASSF5 RASD2 23023127 pred G G G G G G G G G G G G G G G RASD2 ARHGAP20 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G P GP P P G RAP1B RASD2 23023127 pred G G G G G G G G G G G G G G G RASD2 RAB1B 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G G GP P P G RASD2 RAB18 23023127 pred P G GP G G GP G P P P G P GP GP G P GP G GP GP P P G RASD2 RASL12 23023127 pred P G G G G GP G P P G P G GP G G G G GP P P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P42336 Q96D21 pull down 14724584 direct interaction X 2 L7RRS6 Q96D21 pull down 14724584 direct interaction X 2 Q9UI14 Q96D21 two hybrid 19060904 direct interaction X 2 Q96D21 F1T0G5 two hybrid 19255495 direct interaction X 2 P62879 Q96D21 two hybrid 19255495 direct interaction X 2 Q96D21 A0A024R056 two hybrid 19255495 direct interaction X 2 D3DPA4 Q96D21 in vivo 15761153 - X 2 D3DPA4 Q96D21 in vivo 15761153 - X 2 P42336 Q96D21 in vitro 14724584 - X 2 P42336 Q96D21 in vitro 14724584 - X 2 P36897-3 Q96D21 in vivo 15761153 - X 2 P36897-3 Q96D21 in vivo 15761153 - X 2 Q9HAU4 Q96D21 in vivo 15761153 - X 2 Q9HAU4 Q96D21 in vivo 15761153 - X 2 Q96D21 A0A024R274 in vivo 15761153 - X 2 Q96D21 Q15796-2 in vivo 15761153 - X 2 Q96D21 Q9HCE7-2 in vivo 15761153 - X 2 Q96D21 A0A024R274 in vivo 15761153 - X 2 Q96D21 Q9HCE7-2 in vivo 15761153 - X 2 Q96D21 Q15796-2 in vivo 15761153 - X 2 Q15797 Q96D21 in vivo 15761153 - X 2 Q15797 Q96D21 in vivo 15761153 - X 2 O00238 Q96D21 in vivo 15761153 - X 2 O00238 Q96D21 in vivo 15761153 - X 2 Q96D21 P84022-4 in vivo 15761153 - X 2 Q96D21 P84022-4 in vivo 15761153 - X 2 Q9UI14 Q96D21 two hybrid pooling approach 19060904 physical association X 2 Q9UI14 Q96D21 two hybrid array 19060904 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RASD2 RABAC1 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0397(two hybrid array) 19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_262481|UniProt_99273|UniProt_97099 bait|bait|bait prey|prey|prey SMAD3 RASD2 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17927 - - BMPR1B RASD2 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17415 - - SMAD1 RASD2 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17925 - - ACVR1 RASD2 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17230 - - TGFBR1 RASD2 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17932 - - SMAD4 RASD2 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17928 - - GNB1 RASD2 MI:0018(two hybrid) 19255495 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_214376 prey bait RASD2 SMURF1 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17929 - - RASD2 SMURF2 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17931 - - PIK3CA RASD2 MI:0096(pull down)|MI:0492(in vitro) 14724584 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_87137|HPRD_802 bait|- prey|- RAF1 RASD2 MI:0096(pull down) 14724584 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_87135 bait prey GNB2 RASD2 MI:0018(two hybrid) 19255495 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_214377 prey bait SMAD2 RASD2 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17926 - -

PPI - HINT Gene A Gene B PMID Method Quality LRP5 RASD2 26186194 0004 HT LRP6 RASD2 26186194 0004 HT Q6U7G8 RASD2 26186194 0004 HT RASD2 SLC4A7 26186194 0004 HT LRP5 RASD2 26186194 0004 HT LRP6 RASD2 26186194 0004 HT Q6U7G8 RASD2 26186194 0004 HT RASD2 SLC4A7 26186194 0004 HT BMPR1B RASD2 15761153 0019 HT GNB3 RASD2 19255495 0018 LC TGFBR1 RASD2 15761153 0019 HT GNB1 RASD2 19255495 0018 LC GNB2 RASD2 19255495 0018 LC SMAD3 RASD2 15761153 0019 HT ACVR1 RASD2 15761153 0019 HT SMAD4 RASD2 15761153 0019 HT SMAD2 RASD2 15761153 0019 HT SMAD1 RASD2 15761153 0019 HT RASD2 SMURF2 15761153 0019 HT RASD2 SMURF1 15761153 0019 HT RASD2 RABAC1 19060904,19060904,19060904 0018,0397,0398 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96D21 P04049 RASD2 RAF1 0.309 14724584 Q96D21 P16520 RASD2 GNB3 0.309 19255495 Q96D21 P62873 RASD2 GNB1 0.309 19255495 Q96D21 Q86500 RASD2 Q86500 0.126 24955142 Q9UI14 Q96D21 RABAC1 RASD2 0.376 19060904 Q96D21 P42336 RASD2 PIK3CA 0.309 14724584

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 BMPR1B RASD2 MI:0045 experimental interaction detection MI:0461 interaction database LRP5 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database LRP6 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database RAF1 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database GNB3 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database TGFBR1 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database PIK3CA RASD2 MI:0045 experimental interaction detection MI:0461 interaction database RAP1GDS1 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database GNB1 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database GNB2 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database SMAD3 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database ACVR1 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database SMAD4 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database SMAD2 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database SMAD1 RASD2 MI:0045 experimental interaction detection MI:0461 interaction database RASD2 SMURF2 MI:0045 experimental interaction detection MI:0461 interaction database RASD2 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database RASD2 RABAC1 MI:0045 experimental interaction detection MI:0461 interaction database RASD2 SLC4A7 MI:0045 experimental interaction detection MI:0461 interaction database