PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DFFA HERC1 17353931 biogrid exp G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G NOS2 HERC1 23438482 biogrid exp G G G G P G G G G G G G HERC1 TFDP3 26186194 biogrid exp G RSPH10B2 HERC1 26186194 biogrid exp JUN HERC1 20195357 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC1 USP18 26186194 biogrid exp G G G G G G G G G G G G G G G HERC1 MORC1 26186194 biogrid exp G LAPTM5 HERC1 15231748 hprd exp G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G MYL12B HERC1 22863883 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC1 KCMF1 22863883 biogrid exp G G G G G G G G G G G G G GP G G G G G G G G G G G G G G G PTBP3 HERC1 22575643 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC1 ARHGAP29 26186194 biogrid exp G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 GRIPAP1 22863883 biogrid exp G G G G G G G G G G G G G GP G G G G G G G G GP G G HERC2 HERC1 25476789 biogrid exp G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G RAPSN HERC1 26186194 biogrid exp P G G P BRCA1 HERC1 25184681 biogrid exp G G P G P G TTLL1 HERC1 26186194 biogrid exp G G G G G G G G G P G G G G G G G G P G G G HERC1 SCHIP1 20195357 intact exp P P ECHS1 HERC1 26186194 biogrid exp G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G SOX9 HERC1 24155239 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G BYSL HERC1 22863883 biogrid exp G G G G G G G G G G G P G G G G G G G G G G P G G HERC1 DNM3 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G CLTC HERC1 9233772 biogrid exp G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G MLF1 HERC1 26186194 biogrid exp G G G G G G G G G G P G G G G G G G G G G P G G G UBE2D3 HERC1 24155239 biogrid exp G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 BAK1 25408501 biogrid exp G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G EP300 HERC1 16051665 hprd,biogrid exp G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 RNF11 15231748 hprd exp G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G ARF1 HERC1 8861955 biogrid exp G G G G G G G G G G G G GP G G G G G G G G GP G G G TSC2 HERC1 16464865 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC1 UNK 25737280 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PKM HERC1 12650930, 25402006 hprd,biogrid exp, pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 UBE2R2 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 UBE2T 16082366 pred G G G G G G P G G G G G G G UBE2L3 HERC1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2L6 HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 16082366 pred UBE2N HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G CDC34 HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G UBE2I HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 UBE2F 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 AKTIP 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G UBE2A HERC1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC1 WWP1 21836163 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G RAF1 HERC1 25402006 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G WWP2 HERC1 21836163 pred G G G G G G G G G G G G G GP G G G G G G G G G G G G G G G HERC1 UBE2Z 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 UBE2E3 21836163, 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G G G G G UBE2E1 HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G G G G G HERC1 UBE2D4 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G UBE2D2 HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G UBE2H HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G ARF6 HERC1 21836163 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G UBE2G1 HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G PLEK HERC1 21836163 pred G G G G G G G G G G G G G GP G G G G G G G G G G G G G G G HERC1 UBE2S 16082366 pred G G G G G G G G G G G G GP G G G G G G G G G G G G G HERC1 BIRC6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2B HERC1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2C HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 NEDD4L 21836163 pred G G G G G G G G G G G P G G G G G G G G G G G G G G HERC1 SMURF1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G GP G G G HERC1 UBE2U 16082366 pred P P G HERC1 UBE2V2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D1 HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G UBE2M HERC1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 TSG101 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G HERC1 UFC1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CLTC HERC1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 9233772 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_209382|BIOGRID_209386|BIOGRID_209387 prey|bait|prey bait|prey|bait SOX9 HERC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24155239 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_293793|BIOGRID_293794|BIOGRID_293792 bait|prey|prey prey|bait|bait MYL12A HERC1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300136 bait prey EP300 HERC1 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16051665 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_148559|HPRD_26582 bait|- prey|- ARF1 HERC1 MI:0004(affinity chromatography technology) 8861955 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_197793 prey bait c-Jun HERC1 MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_104738 bait prey TSC2 HERC1 MI:0004(affinity chromatography technology) 16464865 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201053 bait prey DFFA HERC1 MI:0004(affinity chromatography technology) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_82966 bait prey HERC1 GRIPAP1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300134 prey bait HERC1 KCMF1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300135 prey bait HERC1 SCHIP1 MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_104572 prey bait BYSL HERC1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300133 bait prey NOS2 HERC1 MI:0004(affinity chromatography technology) 23438482 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_258302 bait prey LAPTM5 HERC1 MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_916 - - HERC1 RNF11 MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_37708 - - UBE2D3 HERC1 MI:0004(affinity chromatography technology) 24155239 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_293795 prey bait PKM HERC1 MI:0096(pull down)|MI:0493(in vivo)|MI:0096(pull down) 12650930 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_133971|HPRD_30851|BIOGRID_133972 bait|-|prey prey|-|bait UBC HERC1 MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21987572,22505724,23000965,23287719 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_267948|BIOGRID_249585|BIOGRID_162920|BIOGRID_170571|BIOGRID_225427|BIOGRID_173688 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality RSPH10B2 HERC1 26186194 0004 HT DFFA HERC1 17353931 0004 HT TTLL1 HERC1 26186194 0004 HT MYL12A HERC1 22863883 0401 HT ECHS1 HERC1 26186194 0004 HT RAPSN HERC1 26186194 0004 HT BYSL HERC1 22863883 0401 HT HERC1 GRIPAP1 22863883 0401 HT HERC1 ARHGAP29 26186194 0004 HT HERC1 TFDP3 26186194 0004 HT HERC1 DKFZP313B1621 26186194 0004 HT HERC1 MORC1 26186194 0004 HT HERC1 KCMF1 22863883 0401 HT HERC1 USP18 26186194 0004 HT HERC1 DNM3 26186194 0004 HT RSPH10B2 HERC1 26186194 0004 HT DFFA HERC1 17353931 0004 HT TTLL1 HERC1 26186194 0004 HT MYL12A HERC1 22863883 0401 HT ECHS1 HERC1 26186194 0004 HT RAPSN HERC1 26186194 0004 HT BYSL HERC1 22863883 0401 HT HERC1 GRIPAP1 22863883 0401 HT HERC1 ARHGAP29 26186194 0004 HT HERC1 TFDP3 26186194 0004 HT HERC1 DKFZP313B1621 26186194 0004 HT HERC1 MORC1 26186194 0004 HT HERC1 KCMF1 22863883 0401 HT HERC1 USP18 26186194 0004 HT HERC1 DNM3 26186194 0004 HT JUN HERC1 20195357 0034 LC PKM HERC1 12650930,12650930 0018,0096 LC MYL12A HERC1 22863883 0401 LC SOX9 HERC1 24155239,24155239 0004,0415 LC CLTC HERC1 9233772,9233772,9233772 0096,0004,0018 LC LAPTM5 HERC1 15231748 0018 HT BYSL HERC1 22863883 0401 LC HERC1 HERC1 26949039,PDB_4O2W 0415,0114 LC HERC1 GRIPAP1 22863883 0401 LC HERC1 KCMF1 22863883 0401 LC HERC1 SCHIP1 20195357 0034 LC HERC1 RNF11 15231748 0018 HT HERC1 HEL-S-30 12650930,12650930 0018,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q15751 Q09472 HERC1 EP300 0.126 16051665 Q15751 P58340 HERC1 MLF1 0.126 26186194 Q5H9I0 Q15751 TFDP3 HERC1 0.126 26186194 Q15751 O14950 HERC1 MYL12B 0.081 22863883 Q9P0J7 Q15751 KCMF1 HERC1 0.081 22863883 Q7CIZ3 Q15751 LACZ HERC1 0.126 20711500 Q86VD1 Q15751 MORC1 HERC1 0.126 26186194 Q15751 O95714 HERC1 HERC2 0.126 25476789 Q15751 O95758 HERC1 PTBP3 0.126 22575643 Q15751 O95922 HERC1 TTLL1 0.126 26186194 Q9CY25 Q15751 MIS12 HERC1 0.236 26496610 Q8CI08 Q15751 SLAIN2 HERC1 0.236 26496610 Q15751 P30084 HERC1 ECHS1 0.126 26186194 Q15751 P35228 HERC1 NOS2 0.126 23438482 Q15751 P38398 HERC1 BRCA1 0.126 25184681 Q9C0B0 Q15751 UNK HERC1 0.126 25737280 Q9P0W5 Q15751 SCHIP1 HERC1 0.126 20195357 Q9UMW8 Q15751 USP18 HERC1 0.126 26186194 Q9UQ16 Q15751 DNM3 HERC1 0.126 26186194 Q15751 P14618 HERC1 PKM 0.523 12650930 Q15751 P48436 HERC1 SOX9 0.569 24155239 Q15751 Q13702 HERC1 RAPSN 0.126 26186194 Q15751 Q13895 HERC1 BYSL 0.081 22863883 Q15751 P19105 HERC1 MYL12A 0.081 22863883 Q15751 P49815 HERC1 TSC2 0.21 16464865 Q15751 Q00610 HERC1 CLTC 0.623 9233772 Q15751 A0A1A9IJH2 HERC1 A0A1A9IJH2 0.126 20711500 Q15751 P05412 HERC1 JUN 0.126 20195357 Q15751 P61077 HERC1 UBE2D3 0.309 24155239 Q15751 P84077 HERC1 ARF1 0.21 8861955 Q15751 Q15751 HERC1 HERC1 0.332 26949039 Q16611 Q15751 BAK1 HERC1 0.396 25408501 Q16763 Q15751 UBE2S HERC1 0.309 26949039 Q8CKC4 Q15751 Q8CKC4 HERC1 0.126 20711500 Q15751 O00273 HERC1 DFFA 0.126 17353931 Q4V328 Q15751 GRIPAP1 HERC1 0.081 22863883 Q15751 B2RC85 HERC1 RSPH10B2 0.126 26186194 Q52LW3 Q15751 ARHGAP29 HERC1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 RSPH10B2 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database DFFA HERC1 MI:0045 experimental interaction detection MI:0461 interaction database HERC2 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database PTBP3 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database TTLL1 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database JUN HERC1 MI:0045 experimental interaction detection MI:0461 interaction database UBC HERC1 MI:0045 experimental interaction detection MI:0461 interaction database PKM HERC1 MI:0045 experimental interaction detection MI:0461 interaction database ECHS1 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database NOS2 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database BRCA1 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database SOX9 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database TSC2 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database SOX10 HERC1 MI:0362 inference MI:0461 interaction database MLF1 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database ARF1 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database CLTC HERC1 MI:0045 experimental interaction detection MI:0461 interaction database EP300 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database LAPTM5 HERC1 MI:0045 experimental interaction detection MI:0461 interaction database RAPSN HERC1 MI:0045 experimental interaction detection MI:0461 interaction database HERC1 BAK1 MI:0362 inference MI:0461 interaction database HERC1 UBE2S MI:0045 experimental interaction detection MI:0461 interaction database HERC1 ARHGAP29 MI:0045 experimental interaction detection MI:0461 interaction database HERC1 TFDP3 MI:0045 experimental interaction detection MI:0461 interaction database HERC1 MORC1 MI:0045 experimental interaction detection MI:0461 interaction database HERC1 UNK MI:0045 experimental interaction detection MI:0461 interaction database HERC1 MIS12 MI:0362 inference MI:0461 interaction database HERC1 SCHIP1 MI:0045 experimental interaction detection MI:0461 interaction database HERC1 SLAIN2 MI:0362 inference MI:0461 interaction database HERC1 USP18 MI:0045 experimental interaction detection MI:0461 interaction database HERC1 DNM3 MI:0045 experimental interaction detection MI:0461 interaction database HERC1 RNF11 MI:0045 experimental interaction detection MI:0461 interaction database