PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KLHL24 FAM219A 26186194 biogrid exp G G G G G GP G G G G G G G G G GP GP G P G G G G G GP G G G G KLHL24 COPS6 19615732 biogrid,intact exp G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G KLHL24 PICK1 18692513 biogrid exp G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G ELAVL1 KLHL24 19322201 biogrid exp G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G TIRAP KLHL24 26186194 biogrid exp G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G PDIA6 KLHL24 26186194 biogrid exp G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G CUL3 KLHL24 21145461 innatedb,biogrid exp G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G PCMT1 KLHL24 26186194 biogrid exp G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G KLHL24 COPS5 19615732,21145461 biogrid,intact exp G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G GRIK2 KLHL24 ortho G GP G G G G P GP P G P UBXN7 KLHL24 25402006 pred G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G ZBTB16 KLHL24 23023127 pred G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G BACH1 KLHL24 23023127 pred G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G TCEB2 KLHL24 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL24 SOCS4 23023127 pred G G G G G GP G G G G G G G G G GP GP G G G G G G G GP G G G G ZBTB6 KLHL24 23023127 pred P P P P P KLHL24 ZBTB3 23023127 pred G G G P G G G G G G GP P G P G G G GP G G G SOCS2 KLHL24 23023127 pred G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G KLHL24 BTBD6 23023127 pred G G G G G G G G G G G G G G G GP G G G G G G G G GP G G G G KLHL24 KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB17 KLHL24 23023127 pred G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G KLHL24 KLHL11 23023127 pred P P P P P G KLHL24 ZBTB45 23023127 pred G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G KLHL24 KLHL23 23023127 pred G G G G G G G G GP G G G G KLHL24 KLHL31 23023127 pred G G G GP G G G G G GP G G G G G G G KLHL24 NACC1 23023127 pred G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G PIK3CA KLHL24 23023127 pred G G G GP G G G G G G G G G P GP G GP G G G G GP G G G SOCS3 KLHL24 23023127 pred G G G G G GP G G G G G G G G G GP GP G GP G G G G G GP G G G G VHL KLHL24 23023127 pred G G G G G G G G G G G G G G G G G G P G G G G G G G G G G ZBED1 KLHL24 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A024R7W9 Q6TFL4 affinity chromatography technology 21145461 physical association X 2 A0A024R7W9 Q6TFL4 affinity chromatography technology 19615732 physical association X 2 P0CG48 Q6TFL4 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q6TFL4 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q6TFL4 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q6TFL4 affinity chromatography technology 21890473 physical association X 2 Q6TFL4 A0A024R1J5 affinity chromatography technology 18692513 physical association X 2 Q6TFL4 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q6TFL4 Q7L5N1 affinity chromatography technology 19615732 physical association X 2 Q6TFL4 anti tag coimmunoprecipitation 19615732 physical association C 35 Q6TFL4 anti tag coimmunoprecipitation 19615732 physical association C 55

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL3 KLHL24 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201933 bait prey KLHL24 PICK1 MI:0004(affinity chromatography technology) 18692513 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_216389 bait prey KLHL24 COPS6 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120496|UniProt_100633 prey|prey bait|bait UBC KLHL24 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21890473,21963094,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_176557|BIOGRID_264550|BIOGRID_268260 bait|bait|bait prey|prey|prey KLHL24 COPS5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_205315|BIOGRID_120495|UniProt_100632 prey|prey|prey bait|bait|bait ELAVL1 KLHL24 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187288 bait prey

PPI - HINT Gene A Gene B PMID Method Quality PCMT1 KLHL24 26186194 0004 HT TIRAP KLHL24 26186194 0004 HT CUL3 KLHL24 21145461 0004 HT PDIA6 KLHL24 26186194 0004 HT KLHL24 COPS6 19615732,19615732 0004,0007 HT KLHL24 FAM219A 26186194 0004 HT KLHL24 COPS5 19615732,21145461,19615732 0004,0004,0007 HT PCMT1 KLHL24 26186194 0004 HT TIRAP KLHL24 26186194 0004 HT CUL3 KLHL24 21145461 0004 HT PDIA6 KLHL24 26186194 0004 HT KLHL24 COPS6 19615732,19615732 0004,0007 HT KLHL24 FAM219A 26186194 0004 HT KLHL24 COPS5 19615732,21145461,19615732 0004,0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6TFL4 P58753 KLHL24 TIRAP 0.126 26186194 Q8IW50 Q6TFL4 FAM219A KLHL24 0.126 26186194 Q9NRD5 Q6TFL4 PICK1 KLHL24 0.21 18692513 Q9JLV5 Q6TFL4 CUL3 KLHL24 0.236 26496610 Q8NEY4 Q6TFL4 ATP6V1C2 KLHL24 0.236 unassigned1304 Q6TFL4 Q53G59 KLHL24 KLHL12 0.236 unassigned1304 Q6TFL4 O43639 KLHL24 NCK2 0.236 unassigned1304 Q7L5N1 Q6TFL4 COPS6 KLHL24 0.236 19615732 Q92905 Q6TFL4 COPS5 KLHL24 0.332 19615732,21145461 Q6TFL4 Q13618 KLHL24 CUL3 0.126 21145461 Q6TFL4 Q15084 KLHL24 PDIA6 0.126 26186194 Q6TFL4 Q15717 KLHL24 ELAVL1 0.126 19322201 Q6TFL4 P22061 KLHL24 PCMT1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBC KLHL24 MI:0045 experimental interaction detection MI:0461 interaction database PCMT1 KLHL24 MI:0045 experimental interaction detection MI:0461 interaction database TIRAP KLHL24 MI:0045 experimental interaction detection MI:0461 interaction database GRIK2 KLHL24 MI:0362 inference MI:0461 interaction database CUL3 KLHL24 MI:0045 experimental interaction detection MI:0461 interaction database PDIA6 KLHL24 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 KLHL24 MI:0045 experimental interaction detection MI:0461 interaction database KLHL24 COPS6 MI:0045 experimental interaction detection MI:0461 interaction database KLHL24 FAM219A MI:0045 experimental interaction detection MI:0461 interaction database KLHL24 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database KLHL24 PICK1 MI:0045 experimental interaction detection MI:0461 interaction database