PTM - CPLM Gene Name UniProt ID Type Position Code STAM2; HBP O75886 Ubiquitination 134 K STAM2; HBP O75886 Ubiquitination 189 K STAM2; HBP O75886 Ubiquitination 202 K STAM2; HBP O75886 Ubiquitination 122 K STAM2; HBP O75886 Ubiquitination 182 K STAM2; HBP O75886 Ubiquitination 353 K STAM2; HBP O75886 Ubiquitination 57 K STAM2; HBP O75886 Ubiquitination 156 K STAM2; HBP O75886 Ubiquitination 283 K STAM2; HBP O75886 Ubiquitination 363 K STAM2; HBP O75886 Ubiquitination 165 K

PTM - dbPAF Gene Name UniProt ID Position Type Species STAM2; HBP O75886 159 T Homo sapiens(Human) STAM2; HBP O75886 160 S Homo sapiens(Human) STAM2; HBP O75886 161 S Homo sapiens(Human) STAM2; HBP O75886 192 Y Homo sapiens(Human) STAM2; HBP O75886 291 Y Homo sapiens(Human) STAM2; HBP O75886 371 Y Homo sapiens(Human) STAM2; HBP O75886 372 S Homo sapiens(Human) STAM2; HBP O75886 374 Y Homo sapiens(Human) STAM2; HBP O75886 375 S Homo sapiens(Human) STAM2; HBP O75886 418 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O75886 S127-p Phosphorylation FQkDPQFsLISATIk O75886 T159-p Phosphorylation SAAAkNGtssNKNkE O75886 S160-p Phosphorylation AAAkNGtssNKNkED O75886 S161-p Phosphorylation AAkNGtssNKNkEDE O75886 S177-p Phosphorylation IAKAIELsLQEQkQQ O75886 S190-p Phosphorylation QQHTETksLyPSSEI O75886 Y192-p Phosphorylation HTETksLyPSSEIQL O75886 Y291-p Phosphorylation KSEPEPVyIDEDKMD O75886 Y371-p Phosphorylation LVNEAPVysVysKLH O75886 S372-p Phosphorylation VNEAPVysVysKLHP O75886 Y374-p Phosphorylation EAPVysVysKLHPPA O75886 S375-p Phosphorylation APVysVysKLHPPAH O75886 Y418-p Phosphorylation QVTVAQSySLGPDQI O75886 K104-ub Ubiquitination IKNKAHPkVCEKLKS O75886 K122-ub Ubiquitination EWSEEFQkDPQFsLI O75886 K134-ub Ubiquitination sLISATIkSMKEEGI O75886 K156-ub Ubiquitination QTVSAAAkNGtssNK O75886 K165-ub Ubiquitination GtssNKNkEDEDIAK O75886 K182-ub Ubiquitination ELsLQEQkQQHTETk O75886 K189-ub Ubiquitination kQQHTETksLyPSSE O75886 K202-ub Ubiquitination SEIQLNNkVARKVRA O75886 K283-ub Ubiquitination DDDVEEIkKSEPEPV O75886 K343-ub Ubiquitination KLEEIDRkHSELSEL O75886 K363-ub Ubiquitination EALELYNkLVNEAPV

PTM - dbPTM UniProt ID Position Code Type Resources References O75886 192 Y Phosphorylation Swiss-Prot 1010711 17081983;17389395;19534553 O75886 291 Y Phosphorylation Swiss-Prot 1010711 17389395 O75886 371 Y Phosphorylation Swiss-Prot 1010711 15144186;19534553 O75886 374 Y Phosphorylation Swiss-Prot 1010711 15144186;15951569;19534553 O75886 192 Y Phosphorylation PhosphoELM.10011 17081983;10993906;11687594 O75886 371 Y Phosphorylation PhosphoELM.10011 15592455;15144186 O75886 374 Y Phosphorylation PhosphoELM.10011 15592455;15144186 O75886 122 K Ubiquitylation Phosphositeplus.1010730 21906983 O75886 134 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O75886 156 K Ubiquitylation Phosphositeplus.1010730 21906983 O75886 165 K Ubiquitylation Phosphositeplus.1010730 21906983 O75886 182 K Ubiquitylation Phosphositeplus.1010730 21906983 O75886 189 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O75886 202 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O75886 283 K Ubiquitylation Phosphositeplus.1010730 21906983 O75886 363 K Ubiquitylation Phosphositeplus.1010730 21906983 O75886 192 Y Phosphorylation Phosphositeplus.1010730 11687594;17016520;17389395;18083107;18180459;19534553;19901323 O75886 291 Y Phosphorylation Phosphositeplus.1010730 17016520;17389395 O75886 371 Y Phosphorylation Phosphositeplus.1010730 14729942;15144186;15570572;15592455;15951569;18083107;18180459;18707149;19534553;19605366;20007894;20090780;20562096;21403953;21447384 O75886 374 Y Phosphorylation Phosphositeplus.1010730 14729942;15144186;15570572;15592455;15951569;18083107;18180459;19534553;19901323;20007894;20090780;20736484;21394647;21403953;21447384 O75886 372 S Phosphorylation HPRD 9.0 15144186 O75886 291 Y Phosphorylation HPRD 9.0 17389395 O75886 371 Y Phosphorylation HPRD 9.0 15144186 O75886 374 Y Phosphorylation HPRD 9.0 15144186,19901323 O75886 192 Y Phosphorylation (EGFR) HPRD 9.0 11687594,10993906,17389395,19901323 O75886 192 Y Phosphorylation SysPTM 1.1 17081983 O75886 371 Y Phosphorylation SysPTM 1.1 18707149

PTM - HPRD Symbol Position Code Type References STAM2 191 Y Phosphorylation 17016520 STAM2 192 Y Phosphorylation 11687594,10993906,17389395,19901323 STAM2 290 Y Phosphorylation 17016520 STAM2 291 Y Phosphorylation 17389395 STAM2 371 Y Phosphorylation 15144186 STAM2 372 S Phosphorylation 15144186 STAM2 374 Y Phosphorylation 15144186,19901323

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O75886 192 Y 17081983 HTP Phosphorylation O75886 192 Y 10993906 LTP Phosphorylation O75886 192 Y 11687594 LTP Phosphorylation O75886 371 Y 15592455 HTP Phosphorylation O75886 371 Y 15144186 HTP Phosphorylation O75886 374 Y 15592455 HTP Phosphorylation O75886 374 Y 15144186 HTP Phosphorylation

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type STAM2 IPI00290542 Y 192 TETKSLpYPSSEIQ phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 10254 115548 - K Ubiquitination 21987572 10254 115548 - K Ubiquitination 21139048 10254 115548 - K Ubiquitination 21890473 10254 115548 - K Ubiquitination 21906983 10254 115548 - K Ubiquitination 21963094 10254 115548 - K Ubiquitination 23000965 10254 115548 - K Ubiquitination 25195858

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID STAM2 Homo sapiens (Human) 156; 189; 202; 283; 182; 122; 165; 134; 363 "156,TVSAAAKNGTSSN; 189,QQHTETKSLYPSS; 202,EIQLNNKVARKVR; 283,DDVEEIKKSEPEP; 182,LSLQEQKQQHTET; 122,WSEEFQKDPQFSL; 165,TSSNKNKEDEDIA; 134,LISATIKSMKEEG; 363,ALELYNKLVNEAP" "156:21906983; 189:21890473,21906983; 202:21890473,21906983; 283:21906983; 182:21906983; 122:21906983; 165:21906983; 134:21890473,21906983; 363:21906983" STAM2 Homo sapiens (Human) 156; 189; 202; 283; 182; 122; 165; 134 "156,TVSAAAKNGTSSN; 189,QQHTETKSLYPSS; 202,EIQLNNKVARKVR; 283,DDVEEIKKSEPEP; 182,LSLQEQKQQHTET; 122,WSEEFQKDPQFSL; 165,TSSNKNKEDEDIA; 134,LISATIKSMKEEG" "156:21906983; 189:21890473,21906983; 202:21890473,21906983; 283:21906983; 182:21906983; 122:21906983; 165:21906983; 134:21890473,21906983"