PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE3D CPSF3 26496610 biogrid,intact exp P GP G P GP P P G GP GP P GP G GP GP G GP G P P GP GP GP G GP P PPP5C UBE3D 25036637 intact exp P GP G P GP P P G GP GP P GP G GP GP G GP G P P GP GP GP GP GP P UBE3D MEMO1 26186194 biogrid exp P P P P P P P P P P P P P P P P P P FKBP6 UBE3D 26186194 biogrid exp GP P P P P P G G G P P CCNB1 UBE3D 15749827 biogrid exp P G P G P G P GP GP G G G G P P GP P GP P UBE3D UBE3D 15749827 biogrid exp P GP G P GP P P G GP GP P GP G GP GP G GP G P P GP GP GP GP GP P UBE2C UBE3D 15749827, 21836163 biogrid exp, pred P GP G P GP P P G GP GP P GP G GP GP G GP G P P GP GP GP GP GP P CCNB2 UBE3D 21836163 pred P P P P P P P G GP GP P G GP G P P G P GP P GP P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7Z6J8 O00762 pull down 15749827 direct interaction X 2 Q7Z6J8 Q7Z6J8 enzymatic study 15749827 direct interaction X 2 Q7Z6J8 P14635 pull down 15749827 direct interaction X 2 Q7Z6J8 P14635 enzymatic study 15749827 direct interaction X 2 P0CG48 Q7Z6J8 affinity chromatography technology 21139048 physical association X 2 Q7Z6J8 Q9BPW0 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality FKBP6 UBE3D 26186194 0004 HT UBE3D DNAAF2 27173435 0676 HT UBE3D CPSF3 26496610,26496610 0007,0004 HT UBE3D MEMO1 26186194 0004 HT FKBP6 UBE3D 26186194 0004 HT UBE3D DNAAF2 27173435 0676 HT UBE3D CPSF3 26496610,26496610 0007,0004 HT UBE3D MEMO1 26186194 0004 HT CCNB1 UBE3D 15749827,15749827 0096,0415 LC PPP5C UBE3D 25036637 0729 HT UBE3D UBE3D 15749827 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7Z6J8 O75344 UBE3D FKBP6 0.126 26186194 Q9Y316 Q7Z6J8 MEMO1 UBE3D 0.126 26186194 Q7Z6J8 O00762 UBE3D UBE2C 0.309 15749827 Q7Z6J8 Q7Z6J8 UBE3D UBE3D 0.332 15749827 Q9NVR5 Q7Z6J8 DNAAF2 UBE3D 0.236 27173435,unassigned1312 Q9UKF6 Q7Z6J8 CPSF3 UBE3D 0.236 26496610 Q7Z6J8 P14635 UBE3D CCNB1 0.523 15749827 Q7Z6J8 G5E962 UBE3D G5E962 0.236 unassigned1304 Q9BPW0 Q7Z6J8 PPP5C UBE3D 0.126 25036637

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBE2C UBE3D MI:0045 experimental interaction detection MI:0461 interaction database FKBP6 UBE3D MI:0045 experimental interaction detection MI:0461 interaction database UBC UBE3D MI:0045 experimental interaction detection MI:0461 interaction database CCNB1 UBE3D MI:0045 experimental interaction detection MI:0461 interaction database UBE3D DNAAF2 MI:0045 experimental interaction detection MI:0461 interaction database UBE3D CPSF3 MI:0045 experimental interaction detection MI:0461 interaction database UBE3D MEMO1 MI:0045 experimental interaction detection MI:0461 interaction database