PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus AREL1 HSP90AA1 22939624 biogrid exp G G G G G GP G G GP G G G G G G G GP G G G G G G G G G G G G AREL1 UBC 25752577 biogrid exp G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 AREL1 23479728 biogrid exp G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 DIABLO 23479728 biogrid exp G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 CRKL 25814554 biogrid,intact exp G G G G G GP G G GP G G G GP G G G GP G G G G G G G G G G G G AREL1 SEPT4 23479728 biogrid exp G G G G G GP G G G G G G G G G G GP G G G G G G G G G AREL1 HTRA2 23479728 biogrid exp G G G G G GP G G GP G GP G GP G G G GP G G G G G G G G G G G G AREL1 HSP90AB1 22939624 intact exp G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2D1 23479728, 16082366 biogrid exp, pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2L3 25752577, 16082366 biogrid exp, pred G G G G G GP G G GP G GP G G G G G GP G G G G G G GP G G G G G AREL1 UBE2Z 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2D4 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2M 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2H 16082366 pred G G G G G GP G G G G GP G GP G G G GP G G G G G G GP G G G G G UBE2L6 AREL1 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G G G G G G G AREL1 UBE2N 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2B 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AREL1 AKTIP 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 BIRC6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AREL1 UBE2E1 16082366 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G GP G G G G G UBE2C AREL1 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2D2 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2I 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G G G G G G G AREL1 UBE2S 16082366 pred G G G G G G G G GP G G G G G G G G G G G G G G G G G AREL1 TSG101 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2T 16082366 pred G G G GP G GP P P G GP G G G G G AREL1 UBE2V2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AREL1 16082366 pred AREL1 CDC34 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2G1 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2R2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AREL1 UBE2A 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AREL1 UFC1 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2F 16082366 pred G G G G G GP G G GP G GP G GP G G G GP G G G G G G GP G G G G G AREL1 UBE2E3 16082366 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G GP G G G G G AREL1 UBE2U 16082366 pred P P P P P P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P07900-2 O15033 affinity chromatography technology 22939624 physical association X 2 P0CG48 O15033 affinity chromatography technology 25147182 physical association X 2 P0CG48 O15033 affinity chromatography technology 21139048 physical association X 2 O15033 O15033 enzymatic study 23479728 direct interaction X 2 A0A087WW00 O15033 pull down 23479728 direct interaction X 2 O43464-2 O15033 affinity chromatography technology 23479728 physical association X 2 O43464-2 O15033 affinity chromatography technology 23479728 physical association X 2 O43464-2 O15033 enzymatic study 23479728 direct interaction X 2 Q9JIY5 O15033 two hybrid 23479728 direct interaction X 2 O15033 affinity chromatography technology 23479728 physical association X 2 O15033 affinity chromatography technology 23479728 physical association X 2 O15033 enzymatic study 23479728 direct interaction X 2 A0A024RBT2 O15033 affinity chromatography technology 23479728 physical association X 2 A0A024RBT2 O15033 affinity chromatography technology 23479728 physical association X 2 A0A024RBT2 O15033 enzymatic study 23479728 direct interaction X 2 Q8ZFX8 O15033 two hybrid pooling approach 20711500 physical association X 2 A0A024RD80 O15033 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q81U80 O15033 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B KIAA0317 UBE2D1 MI:0415(enzymatic study) 23479728 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_272847 bait prey KIAA0317 HSP90AB1 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125029 bait prey KIAA0317 HSP90AA1 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255426 prey bait KIAA0317 DIABLO MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 23479728 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_272849|BIOGRID_272852|BIOGRID_272855 bait|prey|bait prey|bait|prey KIAA0317 UBC MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_168690 prey bait KIAA0317 HTRA2 MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 23479728 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_272850|BIOGRID_272853|BIOGRID_272856 bait|prey|bait prey|bait|prey KIAA0317 SEPT4 MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 23479728 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_272851|BIOGRID_272854|BIOGRID_272857 bait|prey|bait prey|bait|prey

PPI - HINT Gene A Gene B PMID Method Quality AREL1 UBE2D1 25723849,23479728,26949039 0096,0096,0096 LC AREL1 UBE2L3 25752577,25723849 0096,0096 LC AREL1 UBE2D1 25723849,23479728,26949039 0096,0096,0096 LC AREL1 UBE2L3 25752577,25723849 0096,0096 LC AREL1 AREL1 26949039,23479728 0415,0415 LC AREL1 SEPT4 23479728,23479728 0415,0004 LC AREL1 HTRA2 23479728,23479728 0415,0004 LC AREL1 HSP90AB1 22939624 0729 HT AREL1 UBC 25752577,25723849 0415,0415 LC AREL1 CRKL 25814554,25814554,25814554 0397,0018,1356 HT AREL1 DIABLO 23479728,23479728 0415,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P49841 O15033 GSK3B AREL1 0.21 27162139 Q81U80 O15033 Q81U80 AREL1 0.126 20711500 P62837 O15033 UBE2D2 AREL1 0.309 25723849 P61077 O15033 UBE2D3 AREL1 0.309 25723849 Q9JIY5 O15033 HTRA2 AREL1 0.309 23479728 O43236 O15033 SEPT4 AREL1 0.569 23479728 O43464 O15033 HTRA2 AREL1 0.569 23479728 Q9NR28 O15033 DIABLO AREL1 0.569 23479728 P08238 O15033 HSP90AB1 AREL1 0.126 22939624 P07900 O15033 HSP90AA1 AREL1 0.126 22939624 Q8N2W9 O15033 PIAS4 AREL1 0.794 27162139 O15033 O15033 AREL1 AREL1 0.554 23479728,26949039 P0CG48 O15033 UBC AREL1 0.523 25752577,25723849 P68036 O15033 UBE2L3 AREL1 0.671 25752577,25723849,27162139 P46109 O15033 CRKL AREL1 0.376 25814554 P51668 O15033 UBE2D1 AREL1 0.772 23479728,26949039,27162139,25723849 Q8ZFX8 O15033 HISH AREL1 0.126 20711500

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 AREL1 SEPT4 MI:0045 experimental interaction detection MI:0461 interaction database AREL1 HTRA2 MI:0045 experimental interaction detection MI:0461 interaction database AREL1 HSP90AA1 MI:0045 experimental interaction detection MI:0461 interaction database AREL1 HSP90AB1 MI:0045 experimental interaction detection MI:0461 interaction database AREL1 UBC MI:0045 experimental interaction detection MI:0461 interaction database AREL1 HNF4A MI:0045 experimental interaction detection MI:0461 interaction database AREL1 CRKL MI:0045 experimental interaction detection MI:0461 interaction database AREL1 UBE2D1 MI:0045 experimental interaction detection MI:0461 interaction database AREL1 UBE2D3 MI:0045 experimental interaction detection MI:0461 interaction database AREL1 UBE2D2 MI:0045 experimental interaction detection MI:0461 interaction database AREL1 UBE2L3 MI:0045 experimental interaction detection MI:0461 interaction database AREL1 DIABLO MI:0045 experimental interaction detection MI:0461 interaction database